Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells
In this study, DCs were induced from monocytes either by transendothelial trafficking or by culture with granulocyte-macrophage colony-stimulating factor (GM-CSF) + IL-4 + tumor necrosis factor (TNF)-α. Both systems were used to investigate the effects of elevated serum IL-10 level on DC differentiation in SLE patients. The results showed that monocyte-derived DCs induced by either SLE serum or exogenous IL-10 reduced the expression of human leukocyte antigen (HLA)-DR and CD80, decreased IL-12p40 level, and increased IL-10 level, and exhibited an impaired capacity to stimulate allogenic T-cell proliferation. These results...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Sinomenine reduces iNOS expression via inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats
In conclusion, the anti-iNOS effect of sinomenine on EAE is mediated via the suppression of T-bet/IFN-γ pathway. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice
In this study, we sought to determine whether combining these two distinct therapies would yield greater benefit than either drug used alone. We investigated the effect of memantine combined with EE on spatial learning and memory and AD-like pathology in a widely used AD model, the senescence-accelerated prone mice (SAMP8). The SAMP8 mice were randomly assigned to enriched housing (EH) or standard housing (SH), where either memantine (20 mg/kg) or saline was given by gastric lavage once daily continuously for eight weeks. Our results showed that, when provided separately, memantine and EE significantly improved spatial lea...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Overexpression of angiopoietin-1 reduces doxorubicin-induced apoptosis in cardiomyocytes
Publication date: November 2012 Source:Journal of Biomedical Research, Volume 26, Issue 6 Author(s): Danyang Ren , Quan Zhu , Jiantao Li , Tuanzhu Ha , Xiaohui Wang , Yuehua Li Doxorubicin (Dox) is a major anticancer chemotherapeutic agent. However, it causes cardiomyopathy due to the side effect of cardiomyocyte apoptosis. We have previously reported that angiopoietin-1 significantly reduced myocardial infarction after ischemic injury and protected cardiomyocytes from oxidative stress-induced apoptosis. It is hypothesized that angiopoietin-1 may protect cardiomyocytes from Dox-induced apoptosis. Cardiomyocytes H...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Enhanced sympathetic activity and cardiac sympathetic afferent reflex in rats with heart failure induced by adriamycin
Publication date: November 2012 Source:Journal of Biomedical Research, Volume 26, Issue 6 Author(s): Shujuan Zhang , Feng Zhang , Haijian Sun , Yebo Zhou , Ying Han Our previous studies have shown that the cardiac sympathetic afferent reflex is enhanced in rats with chronic heart failure (CHF) induced by coronary artery ligation and contributes to the over-excitation of sympathetic activity. We sought to determine whether sympathetic activity and cardiac sympathetic afferent reflex were enhanced in adriamycin-induced CHF and whether angiotensin II (Ang II) in the paraventricular nucleus (PVN) was involved in enhan...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese
Publication date: November 2012 Source:Journal of Biomedical Research, Volume 26, Issue 6 Author(s): Min Zhang , Yan Zhang , Shuaishuai Zhu , Xiaoyu Li , Qing Yang , Hui Bai , Qi Chen The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease (CAD) in Chinese is...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China
Publication date: November 2012 Source:Journal of Biomedical Research, Volume 26, Issue 6 Author(s): Ping Wang , Satoru Naruse , Hong Yin , Zhongfang Yu , Tianqu Zhuang , Wei Ding , Yanmin Wu , Muxin Wei Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asth...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction
This study was designed to determine the levels of early endothelial progenitor cells (EPCs), apelin, vascular endothelial growth factor (VEGF) and stromal cell-derived growth factor-1 (SDF-1) after acute myocardial infarction (AMI), and to investigate the relationships between these cytokines and early EPCs. Early EPCs, defined as CD133+, KDR+, and CD34+ cells, were quantified by flow cytometry. The levels of early EPCs and those cytokines in AMI patients were significantly different from those with coronary artery disease or controls (P < 0.05). Plasma apelin levels were inversely correlated with Gensini score and...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Omega-3 fatty acid improves the clinical outcome of hepatectomized patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma
In conclusion, administration of omega-3 fatty acid may reduce infection rate and improve liver function recovery in HBV-associated HCC patients after hepatectomy. This improvement is associated with suppressed production of proinflammatory cytokines in these patients. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
