Three dimensional structure prediction and proton nuclear magnetic resonance analysis of toxic pesticides in human blood plasma
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Amit Kumar Sharma , Rajeev Kumar Tiwari , Mulayam Singh Gaur The purpose of this study was to investigate the nuclear magnetic resonance (NMR) assignments of hydrolyzed products extracted from human blood plasma. The correlations between chemical, functional and structural prop-erties of highly toxic pesticides were investigated using the PreADME analysis. We observed that toxic pesticides possessed higher molecular weight and, more hydrogen bond donors and acceptors when compared with less toxic pesticides. The occurrenc...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Bromocriptine enhances the uptake of 99mTc-MIBI in patients with hepatocellular carcinoma
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Xiangting Chai , Qiaoyu Liu , Wenyu Shao , Feng Zhang , Xuehao Wang , Hai Wang 99mTc-methoxyisobutyl isonitrile (MIBI) is a suitable transport substrate for the multidrug resistance gene prod-uct P-glycoprotein (P-gp) and widely used for tumor imaging. Bromocriptine has been shown to inhibit the ATPase activity and the function of P-gp. We hypothesized that bromocriptine could promote the accumulation of MIBI by inhibiting P-gp activities, a feature that can be taken advantage of for enhancing 99mTc-MIBI imaging. In t...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Weekly intravenous nanoparticle albumin-bound paclitaxel for elderly patients with stage IV non-small-cell lung cancer: a series of 20 cases
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Qi Zheng , Yu Yao , Kejun Nan The purpose of this study was to evaluate the efficacy and safety of nanoparticle albumin-bound paclitaxel as a rescue regimen in the treatment of patients with advanced non-small-cell lung cancer. We retrospectively reviewed the medical records of 20 patients with stage IV non-small-cell lung cancer. The patients had progressive disease after standard antitumor therapy and subsequently received intravenous albumin-bound paclitaxel at the dose of 100 mg/m2 in weekly schedule. Cumulative findi...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Admission clinical characteristics and early clinical outcomes among acute ischemic stroke patients
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Xin Gao , Jintao Zhang , Ying Peng , Huanqing Fan , Mei Chen , Tan Xu , Yonghong Zhang The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population. A total of 2,673 patients with acute ischemic stroke were included in the present study. The clinical characteristics at admission and other study variables were collected for all patients. The study outcome was defined as neurological...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Current perspectives of nanoparticles in medical and dental biomaterials
Publication date: May 2012 Source:Journal of Biomedical Research, Volume 26, Issue 3 Author(s): Ibrahim Mohamed Hamouda Nanotechnology is gaining tremendous impetus due to its capability of modulating metals into their nanosize, which drastically changes the chemical, physical and optical properties of metals. Nanoparticles have been introduced as materials with good potential to be extensively used in biological and medical applications. Nanoparticles are clusters of atoms in the size range of 1–100 nm. Inorganic nanoparticles and their nano-composites are applied as good antibacterial agents. Due to the outbreak o...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Gastric cancer presenting with solitary gigantic pelvic metastasis
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Qi Zheng , Kejun Nan , Yu Yao Bone metastasis of gastric cancer is relatively uncommon in clinical practice. Moreover, it is all the more unu-sual for the primary presentation of gastric malignancy to be bone metastasis. Here, we describe a male patient who complained of pain and edema in his right lower extremity. Further assessment by computed tomography and positron emission tomography revealed an abnormally thickened gastric cardia and a giant neoplasm in the right pelvis with bone damage. Consequently, the finding o...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Secondary metabolite credentials of Evolvulus alsinoides by high performance thin layer chromatography (HPTLC)
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Duraisamy Gomathi , Manokaran Kalaiselvi , Ganesan Ravikumar , Dominic Sophia , Velliyur Kanniappan Gopalakrishnan , Chandrasekar Uma Plants and plant-based products are the bases of many modern pharmaceuticals that are current in use today for various diseases. The aim of the study was to investigate the biochemical constituents and high performance thin layer chromatography (HPTLC) finger printing of the ethanolic extract of Evolvulus alsinoides. Phytochemi-cal screening was done by standard procedures and HPTLC met...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Effect of addition of chitosan to self-etching primer: antibacterial activity and push-out bond strength to radicular dentin
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Shaymaa Elsaka , Amr Elnaghy The purpose of this study was to evaluate the antibacterial activity of a modified self-etching primer incorporating chitosan and whether this modification affected the bond strength to radicular dentin. A modified self-etching primer was prepared by adding chitosan solutions at 0.03%, 0.06%, 0.12% and 0.25% (W/W) to RealSeal self-etching primer. RealSeal primer without chitosan was used as the control. The antibacterial activity of the modi-fied self-etching primer was evaluated using the dir...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Flotillin-2 is an acrosome-related protein involved in mouse spermiogenesis
This study indicates that flotillin-2 is a novel Golgi-related protein involved in sperm acrosome biogenesis (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Immunoexpression and prognostic role of p53 in different subtypes of epithelial ovarian carcinoma
In this study, we used immunohistochemical method to investigate the expression patterns of p53 in different subtypes of epithelial ovarian carcinoma. We found that the expressions of p53 protein in epithelial ovarian cancer (pituita, serosity and intima) were 88.9%, 75% and 100%, respectively, while the recurrence rates among three cancer subtypes were significantly different (33.3%, 12.5% and 0%, respectively; P < 0.05). Compared with patients without lymph node metastasis, the expression of p53 in patients with lymph node metastasis was significantly strong (68.75% and 100%, respectively; P < 0.05). Howeve...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma
In conclusion, OGT activation is the main reason for promoting the level of O-GlcNAcation in esophageal squamous cell carcinoma. O-GlcNAcylation may play an important role in esophageal squamous cell carcinoma. (Source: Journal of Biomedical Research)
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Sequential transcatheter arterial chemoembolization, three-dimensional conformal radiotherapy, and high-intensity focused ultrasound treatment for unresectable hepatocellular carcinoma patients
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Shengfa Ni , Lingxiang Liu , Yongqian Shu The purpose of this study was to evaluate the outcome of patients with unresectable hepatocellular carcinoma (HCC) treated by sequential therapy of transcatheter arterial chemoembolization (TACE), three-dimensional con-formal radiotherapy (3-DCRT) and high-intensity focused ultrasound (HIFU). From October, 2005 to September, 2010, 120 patients with unresectable HCC received the sequential treatments of several courses of TACE followed in 2-4 weeks by 3-DCRT and then a single sess...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Peng Zou , Lin Zhao , Haitao Xu , Ping Chen , Aihua Gu , Ning Liu , Peng Zhao , Ailin Lu MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer, heart disease, neurological disorders, vascular abnormalities and autoimmune conditions. Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer, the data have yielded conflicting results. Therefore, this meta-analysis was performed to provide a comprehensive assessment of po-tentia...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Rehabilitation training improves exercise tolerance after percutaneous coronary intervention
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Fang Cui , Yusheng Ren , Heng Jin , Bo Cui The aim of this present study was to investigate the effects of training on exercise tolerance of patients with coronary heart disease after percutaneous coronary intervention. Fifty-seven cases of coronary heart disease after percutaneous coronary intervention were divided randomly into the rehabilitation training group (26 cases) and control group (31 cases). Patients in the rehabilitation training group received rehabilitation training at different stages and exercise intens...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
Reduced turnover times make flexible optical reusable scope with EndoSheath® Technology significantly cost-effective
Publication date: July 2012 Source:Journal of Biomedical Research, Volume 26, Issue 4 Author(s): Deepak Gupta , Arvind Srirajakalidindi , Hong Wang EndoSheath bronchoscopy (Vision Sciences, Inc.) uses a sterile, disposable microbial barrier that may meet the growing needs for safe, efficient, and cost effective flexible bronchoscopy. The purpose of this open-label com-parative study was to compare and calculate the costs-per-airway-procedure of the reusable fiberscope when used with and without EndoSheath® Technology; and to record the turnover time from the completion of the use of each scope until its readiness a...
Source: Journal of Biomedical Research - November 3, 2014 Category: Biochemistry Source Type: research
