Clinical, MRI and electrographic characteristics of three children with Hemiconvulsion-Hemiplegia/Hemiconvulsion-Hemiplegia-Epilepsy (HH/HHE) syndrome –A rare childhood epileptic encephalopathy
Publication date: Available online 6 January 2017 Source:International Journal of Epilepsy Author(s): Yeeshu Singh Sudan, K.P. Vinayan, Arun Grace Roy Hemi convulsion-Hemiplegia-Epilepsy (HH/HHE) syndrome is a very rare catastrophic epileptic syndrome in childhood which follows a prolonged focal motor status epilepticus in infancy and early childhood. Here we are describing the clinical, MRI and electrographic characteristics along with long term outcome of three children with HH/HHE syndrome. A review of the current literature on HH/HHE syndrome is attempted stressing on the diagnostic features and the neurobiologica...
Source: International Journal of Epilepsy - January 6, 2017 Category: Neurology Source Type: research
Melatonin versus chloral hydrate as the sedating agent in performing electroencephalogram in paediatric patients
Publication date: Available online 3 January 2017 Source:International Journal of Epilepsy Author(s): C.L. Yuen, W.W. Cherk, T.H. Fung, C.S. Ho, K.K. Chan, Y.W. Yu Electroencephalography (EEG) is a valuable tool in the diagnosis of epilepsy. The attainment of a high quality EEG requires patient's co-operation which is particularly difficult in children. Chloral hydrate has been used as a sedating agent in EEGs but it has potential serious adverse effects and anti-epileptic activity. Melatonin is used increasingly in different investigations as a safe alternative. Our study is to compare their effectiveness as sedat...
Source: International Journal of Epilepsy - January 3, 2017 Category: Neurology Source Type: research
Measurement and associative factors of adherence to epilepsy drug treatment among the elderly population in Tehran (Iran)
Conclusion Elderly patients had a high treatment adherence and, as logically expected, were associated with comorbid state, divorce-widowhood, and drug-related behavioral side effects particularly behavioral and unsteadiness. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 29, 2016 Category: Neurology Source Type: research
Recurrence rate and risk factors for recurrence of seizures after withdrawal of antiepileptic drugs (AED) in Indian children treated for epilepsy
Publication date: Available online 23 December 2016 Source:International Journal of Epilepsy Author(s): Kavita Srivastava, K.K. Kishore, Karan Topiwala, Surekha Rajadhyaksha (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 22, 2016 Category: Neurology Source Type: research
Obituary: UWE HEINEMANN
Publication date: July–December 2016 Source:International Journal of Epilepsy, Volume 3, Issue 2 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 14, 2016 Category: Neurology Source Type: research
MCQ_Epilepsy Surgery
Publication date: July–December 2016 Source:International Journal of Epilepsy, Volume 3, Issue 2 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 14, 2016 Category: Neurology Source Type: research
Mcq_ijep
Publication date: July–December 2016 Source:International Journal of Epilepsy, Volume 3, Issue 2 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 14, 2016 Category: Neurology Source Type: research
Teaching Series
Publication date: July–December 2016 Source:International Journal of Epilepsy, Volume 3, Issue 2 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 14, 2016 Category: Neurology Source Type: research
Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth
We present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - December 2, 2016 Category: Neurology Source Type: research
Ring chromosome 20 syndrome – A rare chromosomal cause of refractory epilepsy in children
We report a case of a 10-year old boy who had had intractable epilepsy since 2 years of age. Birth history was insignificant and there was no obvious dysmorphism. His motor milestones were normal but cognition and speech were delayed. Electroencephalography showed progressive worsening from initial bi-frontal epileptiform activity to generalized discharges. Neuroimaging and metabolic work up was normal. Karyotype study showed ring chromosome 20. Diagnosis of ring chromosome 20 or r(20) syndrome was made. Ring chromosome 20 syndrome is a rare cause of refractory epilepsy A patient who present with intractable epilepsy with ...
Source: International Journal of Epilepsy - November 3, 2016 Category: Neurology Source Type: research
Unilateral EEG sweat artifacts in a patient of brainstem hemorrhage with central Horner's syndrome
We present an interesting EEG finding of persistent unilateral sweat artifacts in a 47 years old male patient with right hemiplegia secondary to left thalamic bleed with extension of hemorrhage into the left internal capsule, the left midbrain and ventricles. The EEG was done for altered sensorium. It showed unilateral (right sided) sweat artifacts throughout the EEG recording. The anhydrosis on left side of the face was due to left sided Horner's syndrome because of involvement of first order neurons in the left midbrain. This EEG finding is highlighted because of it being relatively less common but interesting finding. (...
Source: International Journal of Epilepsy - November 1, 2016 Category: Neurology Source Type: research
A case series of reflex myoclonic absence epilepsy of infancy – an age-dependent idiopathic generalized epileptic (IGE) syndrome – with good prognosis
Conclusion Reflex myoclonic absence epilepsy is an age-dependent idiopathic generalized epileptic (IGE) syndrome, with an apparently good prognosis. It needs to be recognized separately as new syndrome and should be differentiated from the other myoclonic epilepsies of same age. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - October 29, 2016 Category: Neurology Source Type: research
To evaluate the anti-kindling effect of allopregnanolone alone and its interaction with sodium valporate in pentylenetetrazole induced kindling model
Conclusions It can be concluded that by choosing this combination the dose of sodium valproate can be reduced and thereby reduces the incidence of adverse effects caused by sodium valproate and hence proves to be a useful combination clinically. This study has lead the basis to further investigate the various combinations of neurosteroids and valproate in the process of epileptogenesis with better side effect profile. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - October 29, 2016 Category: Neurology Source Type: research
Macular cherry red spot is an important diagnostic marker in children with myoclonic epilepsies
We present a case series highlighting the importance of a detailed fundoscopic eye examination; particularly when occurring in conjunction with a clinical history of myoclonus, developmental regression and other systemic features in clinching an etiologic diagnosis of storage disorder, specifically, gangliosidosis and sialidosis in children with suspected progressive myoclonus epilepsies. The causes of macular cherry red spot (CRS) on fundoscopic examination are limited and in a given child may provide an important clue for narrowing the differential diagnoses and finally making an accurate diagnosis. Current literature on...
Source: International Journal of Epilepsy - October 29, 2016 Category: Neurology Source Type: research
Drug repositioning
Publication date: Available online 10 October 2016 Source:International Journal of Epilepsy Author(s): Man Mohan Mehndiratta, Swati Anil Wadhai, Brij Kishor Tyagi, Natasha Singh Gulati, Madhu Sinha Rapid advances in pharmacotherapy and bioinformatics has led to the discovery and growing popularity of drug repositioning which includes re-investigating or recycling of existing drugs for new indications. There are innumerable advantages as well as challenges of drug repositioning. Since de-novo drug discovery takes plenty of time, effort and money, it has proved to a preferred alternative strategy for accelerated drug ...
Source: International Journal of Epilepsy - October 10, 2016 Category: Neurology Source Type: research
