MCQ – Pharmacotherapy of Epilepsy
Publication date: January–June 2017 Source:International Journal of Epilepsy, Volume 4, Issue 1 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - June 2, 2017 Category: Neurology Source Type: research
Teaching EEG 5: A familiar EEG pattern with atypical morphology
Publication date: January–June 2017 Source:International Journal of Epilepsy, Volume 4, Issue 1 (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - June 2, 2017 Category: Neurology Source Type: research
Does being ‘well off’ help people with epilepsy cope better? The social impact of epilepsy
Conclusion Personal control is considered to have far-reaching consequences for people's health. The effects of stigma and the unpredictability of epilepsy far outweigh the effects of prosperity for people with epilepsy compared to a random sample of the Australian population. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - June 2, 2017 Category: Neurology Source Type: research
Hydroalcoholic extract of Sargassum Oligocystum attenuates pentylenetetrazole-induced seizures by potentiating antioxidant activity in mice
Conclusion Sargassum oligocystum extract inhibited PTZ-induced seizure. Attenuation of oxidative stress may partly be responsible for the anticonvulsant effects of this alga in the PTZ-induced seizures. Therefore, marine algae, especially Sargassum oligocystum, may be a valuable target to discover new antiepileptic drugs. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - May 17, 2017 Category: Neurology Source Type: research
Bone health in epilepsy
Publication date: Available online 20 April 2017 Source:International Journal of Epilepsy Author(s): Bindu Menon, Man Mohan Mehndiratta Epilepsy is one of the most common neurological disorder usually requiring life long treatment. Long term treatment with antiepileptic drugs (AED’s) is associated with chronic side effects which includes effect on bone health There is a growing volume of literature suggesting that chronic use of AED in patients with epilepsy significantly reduces bone mineral density (BMD) with an increased fracture risk. The causes of these associations are likely to be multifactorial. Unlike other ...
Source: International Journal of Epilepsy - April 21, 2017 Category: Neurology Source Type: research
A first-ever dedicated comprehensive review of incidence of epilepsy in South America and Caribbean
In conclusion, Caribbean needs to come forward for its own epilepsy incidence data especially when risk from numerous factors such as substance abuse, mental health, etc. deems high. Epilepsy incidence in South America is likely to be slightly lower than previously reported although this varies considerably for each country. Inter-population differences are in-part (more than 50%) related to urban-rural differences and variations over time. Our work is especially important to monitor secular trends of epilepsy incidence especially when new data would emerge and countries continue to undergo transitions. (Source: Internatio...
Source: International Journal of Epilepsy - April 1, 2017 Category: Neurology Source Type: research
Focal gigantism in tuberous sclerosis
Publication date: Available online 17 March 2017 Source:International Journal of Epilepsy Author(s): Sanat R. Bhatkar, Aastha Takkar A 38 year lady had recurrent generalized and myoclonic seizures since 6 years of age. On examination she had facial adenoma sebaceum and periungal fibromas, cutaneous angiofibromas on the back. Contrast enhanced magnetic Resonance Imaging of brain was suggestive of multiple cortical tubers with sub ependymal nodules consistent with the diagnosis of Tuberous sclerosis. Focal hypertrophy of the skin of the dorsal aspect of the left hand with focal gigantism was noted. (Source: International...
Source: International Journal of Epilepsy - March 16, 2017 Category: Neurology Source Type: research
Treatment of refractory status epilepticus with electroconvulsive therapy: Need for future clinical studies
The objectives of this article are to do a thorough literature review on use of ECT in refractory-SE; mechanism of action of ECT in refractory-SE; and finally formulate a working protocol for future study of using ECT in patients of refractory-SE. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - March 16, 2017 Category: Neurology Source Type: research
A comparative study of seizures in arterial and venous stroke
Conclusion CVST results in more frequent and early seizures whereas in arterial stroke late seizures are common. Post stroke seizures in ischemic stroke were predicted by carotid territory infarction and venous stroke by parenchymal involvement. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - February 14, 2017 Category: Neurology Source Type: research
A hospital based cross sectional study on comorbid psychiatric problems in persons with epilepsy from north eastern part of India
Conclusions Psychiatric comorbidities are very common in epilepsy. Psychosis associated with epilepsy is seen more in hospital settings. Depression and anxiety though commonly reported in studies are less commonly presented to tertiary care settings. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - February 9, 2017 Category: Neurology Source Type: research
Causative factors and phenomenology of depression in EPILEPSY —A review
Publication date: Available online 2 February 2017 Source:International Journal of Epilepsy Author(s): Rahul Saha, Satyakam Mohapatra, Sujit K. Kar, Bheemsain Tekkalaki, K.S. Anand It is a known fact that depression is the one of the leading causes of years lived with disability and the fourth leading cause of disability-adjusted life-years worldwide. Depression is often under-recognized among patients of epilepsy due to lack of awareness of depressive symptoms. Due to improper management of depression in epileptic patients, it can interfere with treatment outcomes and hence can impair the quality of life. Undermana...
Source: International Journal of Epilepsy - February 1, 2017 Category: Neurology Source Type: research
Psychiatric comorbidity in African patients with epilepsy – Experience from Sierra Leone
Conclusion Symptoms of anxiety and depression are common in epilepsy patients in Sierra Leone. Given the significant negative impacts of such comorbidity on those affected, primary healthcare workers in sub-Saharan countries should be trained to inquire about anxiety and depression symptoms in epilepsy patients, and implementation of screening programs should be considered. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - January 26, 2017 Category: Neurology Source Type: research
Lacosamide as monotherapy in focal seizure: Literature review
Publication date: Available online 12 January 2017 Source:International Journal of Epilepsy Author(s): Kishore R. Sonkusare, Hanmant V. Barkate Lacosamide is a newer approved antiepileptic drug (AED) characterized by its novel pharmacodynamic profile. It is now approved by United States Food and Drug Administration for use as monotherapy in adults (aged >17 years) with focal seizures based on historical controlled trial by Wechsler RT et al in 2014. Randomized controlled trials on lacosamide monotherapy have demonstrated significant reduction in median seizure frequency. In addition, 50% responder rates for laco...
Source: International Journal of Epilepsy - January 12, 2017 Category: Neurology Source Type: research
Early-life status epilepticus induces long-term deficits in anxiety and spatial learning in mice
Conclusions These results demonstrate that a single insult of status epilepticus during the neonatal period is sufficient to cause specific, long-term impairments in anxiety and spatial learning. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - January 9, 2017 Category: Neurology Source Type: research
Plasma tetranectin as a potential clinical biomarker for epilepsy and correlation with clinical and social characteristics
Conclusion The plasma tetranectin level in PWE significantly decreased as the disease progressed irrespective of the stage of epilepsy. Thus, tetranectin could be considered as a potential progressive biomarker for epilepsy. The study outcome suggests further investigation for the possible link of tetranectin levels with clinical and social parameters. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - January 8, 2017 Category: Neurology Source Type: research
