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Immunological Reviews,Volume 282, Issue 1, Page 87-113, March 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Source Type: research
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Immunological Reviews,Volume 282, Issue 1, Page 8-34, March 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Source Type: research
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Immunological Reviews,Volume 282, Issue 1, Page 198-231, March 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Source Type: research
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Immunological Reviews,Volume 282, Issue 1, Page 73-86, March 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Source Type: research
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Immunological Reviews,Volume 282, Issue 1, Page 168-187, March 2018. (Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Source Type: research
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Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Source Type: research
Corrigendum
(Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Tags: CORRIGENDUM Source Type: research
The role of mast cells in autoinflammation
Summary
The concept of autoinflammation was proposed to define a new class of immune disorders categorized by self‐directed inflammation that is driven via activation of innate immune pathways. Within innate immunity, inflammasomes serve as intracellular signaling platforms to endogenous danger molecules and pathogens. Their key function is the cleavage of pro‐interleukin‐1β (pro‐IL‐1β) into its active form to promote inflammation and programmed cell death. A growing number of inflammasome sensors were described, among which NLR family pyrin domain containing 3 (NLRP3) is the best‐studied sensor. Besides macr...
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Hanna Bonnekoh, J örg Scheffel, Naotomo Kambe, Karoline Krause Tags: INVITED REVIEW Source Type: research
Role of mast cells and basophils in pruritus
Summary
To protect our body systems, there is a constant interactive conversation between the skin nervous and immune system. Important elements of this conversation in the skin include mast cells, basophils, and sensory nerve fibers. These cells employ a vast array of sensors that detect danger and react accordingly. This reaction, summarized as neurogenic inflammation, manifests at the conscious level as sensations including pain and itch. Here we provide a perspective on the blossoming knowledge that is illuminating connections between mast cells, basophils, and sensory nerve fibers in the mediation of itch. We discuss ...
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Martin Steinhoff, J örg Buddenkotte, Ethan A. Lerner Tags: INVITED REVIEW Source Type: research
The role and relevance of mast cells in urticaria
In conclusion, autoimmunity, either of Type 1 viz. IgE antibodies to local autoallergens, or Type 2b, viz. IgG autoantibodies to IgE or its receptor, are considered to be the most frequent causes of CSU. In both cases, the mast cell is likely to be the axial cell in producing the wheals. (Source: Immunological Reviews)
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Martin K. Church, Pavel Kolkhir, Martin Metz, Marcus Maurer Tags: INVITED REVIEW Source Type: research
The controversial role of mast cells in fibrosis
Summary
Fibrosis is a medical condition characterized by an excessive deposition of extracellular matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases and can affect all organs. The excessive extracellular matrix accumulation in these conditions can often have serious consequences and in many cases be life‐threatening. A typical event seen in many fibrotic conditions is a profound accumulation of mast cells (MCs), suggesting that these cells can contribute to the pathology. Indeed, there is now substantialv evidence pointing to an important role of MCs in fibrotic disease. However, ...
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Peter Bradding, Gunnar Pejler Tags: INVITED REVIEW Source Type: research
The contribution of mast cells to bacterial and fungal infection immunity
Summary
Mast cells are hematopoietic progenitor‐derived, granule‐containing immune cells that are widely distributed in tissues that interact with the external environment, such as the skin and mucosal tissues. It is well‐known that mast cells are significantly involved in IgE‐mediated allergic reactions, but because of their location, it has also been long hypothesized that mast cells can act as sentinel cells that sense pathogens and initiate protective immune responses. Using mast cell or mast cell protease‐deficient murine models, recent studies by our groups and others indicate that mast cells have pleiotrop...
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Adrian M. Piliponsky, Luigina Romani Tags: INVITED REVIEW Source Type: research
Mast cell ‐neural interactions contribute to pain and itch
Summary
Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a “power house” by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus. Mechanis...
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Kalpna Gupta, Ilkka T. Harvima Tags: INVITED REVIEW Source Type: research
Human eosinophils and mast cells: Birds of a feather flock together
Summary
While the origin of the phrase “birds of a feather flock together” is unclear, it has been in use for centuries and is typically employed to describe the phenomenon that people with similar tastes or interests tend to seek each other out and congregate together. In this review, we have co‐opted this phrase to compare innate immune cells of related origin, the eosinophil and mast cell, because they very often accumulate together in tissue sites under both homeostatic and inflammatory conditions. To highlight overlapping yet distinct features, their hematopoietic development, cell surface phenotype, mediator re...
Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Piper A. Robida, Pier Giorgio Puzzovio, Hadas Pahima, Francesca Levi ‐Schaffer, Bruce S. Bochner Tags: INVITED REVIEW Source Type: research
