The role and relevance of mast cells in urticaria

In conclusion, autoimmunity, either of Type 1 viz. IgE antibodies to local autoallergens, or Type 2b, viz. IgG autoantibodies to IgE or its receptor, are considered to be the most frequent causes of CSU. In both cases, the mast cell is likely to be the axial cell in producing the wheals.

Source: Immunological Reviews - February 12, 2018 Category: Allergy & Immunology Authors: Martin K. Church, Pavel Kolkhir, Martin Metz, Marcus Maurer Tags: INVITED REVIEW Source Type: research