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Plasma cell myeloma with Auer rode like inclusions
Publication date: June 2018Source: Hematology/Oncology and Stem Cell Therapy, Volume 11, Issue 2Author(s): Nour AlMozain, Tarek Owaidah (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Reduced intensity is preferred over myeloablative conditioning allogeneic HCT in chronic lymphocytic leukemia whenever indicated: A systematic review/meta-analysis
We report the results in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Based on lower non-relapse mortality and slightly better overall survival rates, reduced intensity conditioning regimens appear to be the most desirable choice whenever the procedure is indicated for this disease. It appears highly unlikely that a RCT will be ever performed comparing reduced intensity vs. myeloablative allogeneic hematopoietic cell transplantation in chronic lymphocytic leukemia. In the absence of such a study, results of this systematic review/meta-analysis represent the best available...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Study of platelet activation, hypercoagulable state, and the association with pulmonary hypertension in children with β-thalassemia
ConclusionA chronic hypercoagulable state and platelet activation is present in children with β-thalassemia. Splenectomy and transfusion infrequency are the main risk factors noted to be associated with such hypercoagulable state and platelet activation and consequently the PH among our thalassemic patients. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

CD209-336A/G promotor polymorphism and its clinical associations in sickle cell disease Egyptian Pediatric patients
ConclusionWe found no significant difference between our population of Egyptian SCD cases and controls regarding CD209 A>G polymorphism. Infections occurred more frequently among the heterozygous genotype (AG) and homozygous genotype (GG) patients. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Rosai-Dorfman disease masquerading as Uveal Melanoma: Case report and review of literature
ConclusionRDD can present as an intraocular mass that mimics ciliary body melanoma. This case emphasizes the importance of diagnostic biopsy before considering the final therapy in unclear cases, mainly when associated with unusual systemic features like lymphadenopathy. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Parvovırus-induced thrombocytopenıa
Publication date: Available online 15 June 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Burak Furkan Demir, Aysenur Karahan Meteris, Gokhan Yirgin, Mustafa Comoglu, Bilal Katipoglu, Nisbet Yılmaz, Ihsan Ates (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Philadelphia chromosome-positive lymphoblastic lymphoma—Is it rare or underdiagnosed?
Publication date: Available online 15 June 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Ahmad Alshomar, Riad El FakihAbstractLymphoblastic lymphomas (LBLs) are neoplasms of precursor B and T cells; they are considered in the same spectrum as precursor B and T cell acute lymphoblastic leukemia (ALL). The World Health Organization classification classifies both LBL and ALL as one disease entity. While chromosome abnormalities are well defined with all of their therapeutic and prognostic implications in ALL, these are not well studied in LBL. Here, we describe a case of Philadelphia chromosome-positive LBL ...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Granulocytic sarcoma and mediastinal germ cell tumor: A common cell of origin?
Publication date: Available online 15 June 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Sarbajit Mukherjee, Sami Ibrahimi, Teresa Scordino, Mohamad Cherry (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Retrospective evaluation of fidaxomicin versus oral vancomycin for treatment of Clostridium difficile infections in allogeneic stem cell transplant
ConclusionThe findings of this study suggest that oral vancomycin and fidaxomicin are comparable options for CDI treatment in allogeneic SCT patients within 100 days following transplant. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Acquired factor X deficiency in light-chain (AL) amyloidosis is rare and associated with advanced disease
Publication date: Available online 28 June 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Gina Patel, Parameswaran Hari, Aniko Szabo, Lisa Rein, Lisa Baumann Kreuziger, Saurabh Chhabra, Binod Dhakal, Anita D'SouzaAbstractSystemic light-chain (AL) amyloidosis can lead to an acquired coagulopathy secondary to acquired factor X (aFX) deficiency. However, it is not very clear who develops aFX deficiency in AL amyloidosis. We, therefore, undertook this single-center study to better characterize AL amyloidosis-associated aFX deficiency. Out of 121 AL patients who had FX testing at the time of their first evaluat...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Presentation and diagnosis of patients with type 3 von Willebrand disease in resources-limited laboratory
In this study the sensitivity of VWF:Ag is only 78%, the sensitivity of VWF:RiCof is 92% of diagnosed cases. From our results it can be concluded that patients with type 3 VWD are usually presented with moderate/severe mucocutaneous bleeding that is associated with prolonged bleeding time test of>10 min and a family history of similar type of bleeding. This fact was frequently utilized to provisionally diagnose several members of the same family, forming a cohort of patients that is larger than the number of objectively-diagnosed patients included in this study, when they cannot afford to be all tested with VWF:Ag/VWF:Ri...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

A novel TNFRSF1A gene mutation in a patient with tumor necrosis factor receptor-associated periodic syndrome
Publication date: Available online 19 October 2016Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Alireza Khabazi, Mahafarin Maralani, Sasan Andalib, Ebrahim SakhiniaAbstractTumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a periodic fever syndrome inherited in an autosomal dominant fashion. It stems from mutations in the TNFRSF1A (accession number: NM_001065) gene expressing the receptor for tumor necrosis factor α. A patient with TRAPS may present with prolonged episodes of fever attacks, abdominal pain, severe myalgia, and painful erythema on the trunk or extremities. Here, we report a...
Source: Hematology Oncology and Stem Cell Therapy - July 5, 2018 Category: Cancer & Oncology Source Type: research

Synovial sarcoma of the hard palate: The third case in the medical literature
Publication date: Available online 1 February 2017Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Aseel Doubi, Motaz Doubi, Nabil Alzaher, Asma TulbahAbstractSynovial sarcoma is a high-grade soft tissue sarcoma that rarely arises in the head and neck region. It affects the parapharyngeal space and the hypopharynx most commonly and it has different presentations based on the affected site. In extremely rare occasions, it involves the hard palate such as in our case where a 24-year-old female patient presented with a mass lesion involving the left hard palate, which was identified clinically and by imaging studie...
Source: Hematology Oncology and Stem Cell Therapy - July 5, 2018 Category: Cancer & Oncology Source Type: research

A case of T-cell lymphoproliferative disorder associated with hypereosinophilia with excellent response to mycophenolate mofetil
We report a case of T-cell lymphoproliferation associated with hypereosinophilia, which has been successfully treated with mycophenolate mofetil, with resolution of skin lesions and normalization of eosinophil count and immunoglobulin E level. We believe this is a clinically relevant case since this is a rare disease with little known knowledge on its best treatment modality. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 5, 2018 Category: Cancer & Oncology Source Type: research

Diagnosis of variant RARA translocation using standard dual-color dual-fusion PML/RARA FISH probes: An illustrative report
Publication date: Available online 1 February 2017Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Manish Kumar Singh, Mayur Parihar, Neeraj Arora, Deepak Kumar Mishra, Saurabh Jayant Bhave, Mammen ChandyAbstractAcute promyelocytic leukemia (APML) with variant RARa translocations comprises 1–2% of APML cases. However, the diagnosis of these cases is challenging as the routine practice includes fluorescence in situ hybridization (FISH) reverse transcription polymerase chain reaction targeting the PML and RARA genes to detect PML/RARA fusions. Here, we report a case highlighting the importance of atypical FISH s...
Source: Hematology Oncology and Stem Cell Therapy - July 5, 2018 Category: Cancer & Oncology Source Type: research