Hematology Oncology and Stem Cell Therapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Durable remission of a patient with primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Publication date: Available online 28 September 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Shaima M. Al Aoun, Shahid Iqbal, Tahani M. AlHalouli, Syed Z. Zaidi, Ibraheem H. MotabiAbstractPrimary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (CD8+ PCAETL) is a rare disease characterized by aggressive clinical course and short survival. All available data are extracted from case reports and case series. The outcome is dismal and only two reported cases were cured after several lines of therapies including stem cell transplant. We herein present the case of a patient with CD8+ PCAETL w...
Source: Hematology Oncology and Stem Cell Therapy - October 4, 2018 Category: Cancer & Oncology Source Type: research

Cutaneous Amyloidosis Light-Chain Amyloidosis With Multiple Myeloma: A Concise Review
ConclusionsWe reviewed the constellation of the cutaneous manifestations of AL amyloidosis with concurrent MM. We found a female predominance, and more than half presented as hemorrhagic bullous lesions. There is a preponderance of λ light chains over kappa (κ) light chains, both as a free light chain (15% vs. 4%) and as an intact Ig (38% vs. 24%; absolute number of 14 vs. 7 patients, respectively). In the subgroup of patients with bullous skin lesions, λ light chain was present in eight cases and κ light chain in seven cases. All κ light chain subtypes presented with bullous lesions and no other cutaneous types of le...
Source: Hematology Oncology and Stem Cell Therapy - September 22, 2018 Category: Cancer & Oncology Source Type: research

Clinical and Histopathological Spectrum of Toxic Erythema of Chemotherapy in Patients Who Have Undergone Allogenic Hematopoietic Cell Transplantation
ConclusionThe diagnosis of TEC should be considered after a correlation of clinical and histological findings in conjunction with a timeline of chemotherapy administration. TEC is a clinical diagnosis that is supported by pathological confirmation. Suggested criteria for the diagnosis of TEC may be helpful to dermatologists and clinicians when caring for these patients. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - September 21, 2018 Category: Cancer & Oncology Source Type: research

Vitamin D Deficiency and Graft-Versus-Host Disease in Hematopoietic Stem Cell Transplant Population
Publication date: Available online 8 September 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Abeer ArainAbstractVitamins are the organic compounds that have long been known to play a significant role in our body by functioning as hormones and antioxidants. Vitamin D, a fat-soluble vitamin, is the main regulator of calcium hemostasis in our body. At the same time, it is also known to show its potential effects on the immune system by modulating the differentiation, activation, and proliferation of T and B lymphocytes. The immunomodulatory properties of vitamin D are also known to have a crucial role in the...
Source: Hematology Oncology and Stem Cell Therapy - September 9, 2018 Category: Cancer & Oncology Source Type: research

Combined Haploidentical and Umbilical Cord Blood Transplantation for Severe Aplastic Anemia: Unique Hematopoietic Reconstitution
Publication date: Available online 29 August 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Anant Vatsayan, Hasan Hashem, Kristen Nagle, Linda Cabral, Hillard Lazarus, Jignesh DalalAbstractHematopoietic stem cell transplant (HSCT) with matched sibling donor (MSD) is considered the first line of therapy for patients with severe aplastic anemia (SAA) who are < 40 years of age1. Immunosuppressive therapy (IST) and alternative donor HSCT are other modalities of treatment1. Due to non- availability of a MSD for two- thirds of the SAA patients and a significant rate of failure of IST, alternative donor HSCT ...
Source: Hematology Oncology and Stem Cell Therapy - August 30, 2018 Category: Cancer & Oncology Source Type: research

BCL-2 Overexpression Overcomes Cell of Origin Stratification in Diffuse Large B-Cell Lymphoma
Publication date: Available online 29 July 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Moussab Damlaj, Rehab Yassin, Saeed Al-Shieban, Tabreez Pasha, Mohsen Al Zahrani, Ayman Alhejazi, Ahmad Alaskar (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 30, 2018 Category: Cancer & Oncology Source Type: research

Autologous Hematopoietic Stem Cell Transplant Is Safe for Elderly Lymphoma Patients
Publication date: Available online 29 July 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Ghulam Rehman Mohyuddin, Nicole Romanelli, Leyla Shune, Sunil Abhyankar, Siddhartha Ganguly, Joseph McGuirk, Anurag Singh (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 30, 2018 Category: Cancer & Oncology Source Type: research

Kidney Dysfunction after Hematopoietic Cell Transplantation—Etiology, Management, and Perspectives
Publication date: Available online 29 July 2018Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Dorota Jaguś, Karol Lis, Longin Niemczyk, Grzegorz W. BasakAbstractKidney dysfunction is a common complication of hematopoietic cell transplantation (HCT) with proven negative impact on early and long-term mortality. Causes of this complication are diverse, usually overlapping, and poorly understood. Therefore, management implicates multidirectional investigations and simultaneous treatment of suspected causes. The etiology is frequently unconfirmed due to a lack of specific markers and prevalence of contraindication...
Source: Hematology Oncology and Stem Cell Therapy - July 30, 2018 Category: Cancer & Oncology Source Type: research

Romiplostim for Thrombocytopenia Following Allogeneic Stem Cell Transplantation: A Case Series
We report on the outcomes of five patients at our institution who received romiplostim for either primary engraftment failure or secondary failure of platelet recovery following stem cell transplantation. In total, four out of the five patients demonstrated a response to romiplostim, which was defined as seven consecutive days of platelet count>50 × 109/L with transfusion independence, with two ongoing responses (>365 days each) at the conclusion of the study period. Responses to romiplostim were sustained in the absence of significant bone marrow disease, which was found to contribute to recurrent thrombocytopenia. Addit...
Source: Hematology Oncology and Stem Cell Therapy - July 18, 2018 Category: Cancer & Oncology Source Type: research

Role of Red Blood Cells “Annexin V” and Platelets “P-Selectin” in Patients with Thalassemia
ConclusionThe mean expression of platelets P-selectin in patients with thalassemia major and thalassemia intermedia was significantly higher than that in controls and patients with thalassemia minor. However, its expression was significantly higher in patients with thalassemia intermedia than in those with thalassemia major. Annexin V also showed a positive correlation with P-selectin, and both markers positively correlated with regularity of blood transfusion. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 18, 2018 Category: Cancer & Oncology Source Type: research

A novel TNFRSF1A gene mutation in a patient with tumor necrosis factor receptor-associated periodic syndrome
Publication date: Available online 19 October 2016Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Alireza Khabazi, Mahafarin Maralani, Sasan Andalib, Ebrahim SakhiniaAbstractTumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a periodic fever syndrome inherited in an autosomal dominant fashion. It stems from mutations in the TNFRSF1A (accession number: NM_001065) gene expressing the receptor for tumor necrosis factor α. A patient with TRAPS may present with prolonged episodes of fever attacks, abdominal pain, severe myalgia, and painful erythema on the trunk or extremities. Here, we report a...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Synovial sarcoma of the hard palate: The third case in the medical literature
Publication date: Available online 1 February 2017Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Aseel Doubi, Motaz Doubi, Nabil Alzaher, Asma TulbahAbstractSynovial sarcoma is a high-grade soft tissue sarcoma that rarely arises in the head and neck region. It affects the parapharyngeal space and the hypopharynx most commonly and it has different presentations based on the affected site. In extremely rare occasions, it involves the hard palate such as in our case where a 24-year-old female patient presented with a mass lesion involving the left hard palate, which was identified clinically and by imaging studie...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

A case of T-cell lymphoproliferative disorder associated with hypereosinophilia with excellent response to mycophenolate mofetil
We report a case of T-cell lymphoproliferation associated with hypereosinophilia, which has been successfully treated with mycophenolate mofetil, with resolution of skin lesions and normalization of eosinophil count and immunoglobulin E level. We believe this is a clinically relevant case since this is a rare disease with little known knowledge on its best treatment modality. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Diagnosis of variant RARA translocation using standard dual-color dual-fusion PML/RARA FISH probes: An illustrative report
Publication date: Available online 1 February 2017Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Manish Kumar Singh, Mayur Parihar, Neeraj Arora, Deepak Kumar Mishra, Saurabh Jayant Bhave, Mammen ChandyAbstractAcute promyelocytic leukemia (APML) with variant RARa translocations comprises 1–2% of APML cases. However, the diagnosis of these cases is challenging as the routine practice includes fluorescence in situ hybridization (FISH) reverse transcription polymerase chain reaction targeting the PML and RARA genes to detect PML/RARA fusions. Here, we report a case highlighting the importance of atypical FISH s...
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research

Acute myeloid leukemia in a patient with thrombocytopenia with absent radii: A case report and review of the literature
We report a case of myelodysplastic syndrome progressing to AML with calreticulin driver mutation in an adult male with TAR syndrome who was successfully treated with hematopoietic allogeneic stem cell transplantation. (Source: Hematology Oncology and Stem Cell Therapy)
Source: Hematology Oncology and Stem Cell Therapy - July 10, 2018 Category: Cancer & Oncology Source Type: research