Three-dimensional printed tissue engineered bone for canine mandibular defects
ConclusionsThe tissue-engineered bone was constructed by 3D printing mold and high-temperature sintering to produce nanoporous hydroxyapatite scaffolds, which repair in situ bone defects in experimental dogs. The time of compositing for tissue engineered bone was reduced from 8 d to 2 d without the in vivo effect. (Source: Genes and Diseases)
Source: Genes and Diseases - May 10, 2019 Category: Genetics & Stem Cells Source Type: research
HCV infection causes cirrhosis in human by step-wise regulation of host genes involved in cellular functioning and defense during fibrosis: identification of bio-markers
Publication date: Available online 8 May 2019Source: Genes & DiseasesAuthor(s): Bushra Ijaz, Waqar Ahmad, Trina Das, Khadija Shabbiri, Tayyab Husnain, Sajida HassanAbstractChronic Hepatitis C Viral (HCV) infection is a leading health problem worldwide and resulted in fibrotic scar formation, and finally liver-cirrhosis. Although contemporary therapies can partially reverse this destructive process, the rehabilitation is too slow and unsuitable for all chronic infections. The current study elucidates the mechanism of disease progression from early (F1) to moderate (F2, F3), and to severe fibrosis (F4)/cirrhosis in HCV genot...
Source: Genes and Diseases - May 8, 2019 Category: Genetics & Stem Cells Source Type: research
Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs)
Publication date: Available online 8 May 2019Source: Genes & DiseasesAuthor(s): Linghuan Zhang, Qing Luo, Yi Shu, Zongyue Zeng, Bo Huang, Yixiao Feng, Bo Zhang, Xi Wang, Yan Lei, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Xian Chen, Bin Liu, William Wagstaff, Russell R. Reid, Hue H. Luu, Rex C. Haydon, Michael J. LeeAbstractMesenchymal stem cells (MSCs) are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes, chondrocytes, adipocytes, tenocytes and myocytes. MSCs represent one of the most commonly-used adult progenitors and serve as excellent p...
Source: Genes and Diseases - May 8, 2019 Category: Genetics & Stem Cells Source Type: research
Microvesicles (MIVs) secreted from adipose-derived stem cells (ADSCs) contain multiple microRNAs and promote the migration and invasion of endothelial cells
Publication date: Available online 25 April 2019Source: Genes & DiseasesAuthor(s): Bo Huang, Lin-Feng Huang, Ling Zhao, Zongyue Zeng, Xi Wang, Daigui Cao, Lijuan Yang, Zhenyu Ye, Xian Chen, Bin Liu, Tong-Chuan He, Xiaozhong WangAbstractExtracellular vesicles (EVs) such as microvesicles (MIVs) play an important role in intercellular communications. MIVs are small membrane vesicles sized 100–1000 nm in diameter that are released by many types of cells, such as mesenchymal stem cells (MSCs), tumor cells and adipose-derived stem cells (ADSC). As EVs can carry out autocrine and paracrine functions by controlling multiple cell...
Source: Genes and Diseases - April 25, 2019 Category: Genetics & Stem Cells Source Type: research
Biomechanical analysis of the computer-assisted internal fixation of a femoral neck fracture
Publication date: Available online 23 April 2019Source: Genes & DiseasesAuthor(s): Hui Lu, Hongquan Shen, Shuqing Zhou, Weidong Ni, Dianming JiangAbstractThe number and spatial configuration of the screws will affect the stability and prognosis of the fractures. In our study, we assessed the biomechanical effects of the double-head cannulated compression screw(DhCCS) and ordinary cannulated compression screw(OCCS) for the treatment of femoral neck fractures by using computer finite element analysis. The original digital imaging and communications in medicine(DICOM)data of a proximal femur were imported into Materiaise's in...
Source: Genes and Diseases - April 25, 2019 Category: Genetics & Stem Cells Source Type: research
