Immune checkpoint: the novel target for antitumor therapy
Publication date: Available online 20 December 2019Source: Genes & DiseasesAuthor(s): Xianghu Jiang, Guohong Liu, Yirong Li, Yunbao PanAbstractInhibitory checkpoint molecules include programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), cytotoxic T lymphocyte antigen-4 (CTLA-4), human endogenous retrovirus-H Long terminal repeat-associating 2 (HHLA2), B7 homolog 4 protein (B7-H4), T cell membrane protein-3 (TIM-3) and Lymphocyte-activation gene 3 (LAG-3), which are up-regulated during tumorigenesis. These pathways are essential to down-regulate the immune system by blocking the activation of T cells. In r...
Source: Genes and Diseases - December 20, 2019 Category: Genetics & Stem Cells Source Type: research
A novel FZD6 mutation revealed the cause of cleft lip and/or palate in a Chinese family
In conclusion, the results suggest c.1A>GAtg/Gtg in the FZD6 (NM_001164616) might be the genetic etiology for non-syndromic CL/P in this pedigree. Furthermore, this finding provided new etiologic information, supplementing the evidence that FZD6 is a strong potential gene for CL/P. (Source: Genes and Diseases)
Source: Genes and Diseases - December 20, 2019 Category: Genetics & Stem Cells Source Type: research
Extracellular vesicles in neurodegenerative diseases: Insights and New Perspectives
Publication date: Available online 14 December 2019Source: Genes & DiseasesAuthor(s): Qian Yuan, Xiao-dong Li, Si-miao Zhang, Hong-wei Wang, Yun-liang WangAbstractExtracellular vesicles (EVs) are vesicle-like substances released by eukaryotic cells. Based on their origin and size, EVs are mainly divided into exosomes, microvesicles and apoptotic bodies, and they are secreted by eukaryotic cells under physiological and pathological conditions. EVs are enriched with nucleic acids, proteins and other factors. EVs can regulate the function of adjacent and distant cells, and they are even involved in the pathogenesis of disease...
Source: Genes and Diseases - December 15, 2019 Category: Genetics & Stem Cells Source Type: research
The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in Cancer Metastasis
Publication date: Available online 5 December 2019Source: Genes & DiseasesAuthor(s): Mohammad Reza Zinatizadeh, Seyed Rouhollah Miri, Peyman Kheirandish Zarandi, Ghanbar Mahmoodi Chalbatani, Catarina Rapôso, Hamid Reza Mirzaei, Mohammad Esmaeil Akbari, Habibollah MahmoodzadehAbstractHippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell growth. This pathway is activated in response to cell cycle arrest signals (cell polarity, transduction, and DNA damage) and limited by growth factors or mitogens associated with EGF and LPA. The major pathway co...
Source: Genes and Diseases - December 6, 2019 Category: Genetics & Stem Cells Source Type: research
Proceedings of the National Conference on Biotechnology Innovations (NatConBio-2019), Barabanki, Uttar Pradesh, India, September 27–28, 2019
Publication date: Available online 2 November 2019Source: Genes & DiseasesAuthor(s): Sunil Kumar (Source: Genes and Diseases)
Source: Genes and Diseases - December 5, 2019 Category: Genetics & Stem Cells Source Type: research
Immune checkpoint molecules: “new” kids on the block of skin photoimmunology
Publication date: Available online 4 December 2019Source: Genes & DiseasesAuthor(s): Wei Wang, Zhao-Hui WuAbstractUltraviolet radiation (UVR) is a prominent etiological factor of the pathogenesis of skin diseases such as squamous cell carcinoma and melanoma. Excessive exposure to the natural sources of UVR such as sunlight or artificially from tanning lamps has been linked to the increasing incidence of skin cancers in the United States. Besides the skin inflammation, DNA damage and oncogenic mutation caused by UVR, UV exposure also plays a critical role in suppressing local and systemic immune responses which enable prema...
Source: Genes and Diseases - December 5, 2019 Category: Genetics & Stem Cells Source Type: research
Genetic investigation of haemoglobinopathies in a large cohort of asymptomatic individuals reveals a higher carrier rate for β-thalassemia in Sichuan Province (Southwestern China)
Publication date: Available online 25 November 2019Source: Genes & DiseasesAuthor(s): Xia Yu, Min Lin, Chenggui Liu, Zhiyong Liao, Yongqiong Wei, Rui Liu, Jing ZhuAbstractThe incidence of haemoglobinopathy is high in China, especially south of the Yangtze River. However, the exact status of haemoglobinopathy in Sichuan is unknown. To carry out a detailed research of haemoglobinopathy in individuals living in Sichuan, 13,298 subjects without clinical symptoms who were living in Sichuan Province, with an age distribution of 5-73 years, were included in this study. Between March 2014 and July 2017, these subjects received exa...
Source: Genes and Diseases - November 26, 2019 Category: Genetics & Stem Cells Source Type: research
Proceedings and National Conference on Biotechnology Innovations (NatConBio-2019), Barabanki, Uttar Pradesh, India, September 27–28, 2019
Publication date: Available online 2 November 2019Source: Genes & DiseasesAuthor(s): Sunil Kumar (Source: Genes and Diseases)
Source: Genes and Diseases - November 23, 2019 Category: Genetics & Stem Cells Source Type: research
Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine
Publication date: Available online 30 October 2019Source: Genes & DiseasesAuthor(s): Manish Pratap Singh, Sandhya Rai, Ashutosh Pandey, Nand K. Singh, Sameer SrivastavaAbstractMolecular subtypes-based therapies offer new potential framework for desired and precise outcome in clinical settings. Current treatment strategies in colorectal cancer are largely ‘one drug fit all’ model for patients that display same pathological conditions. However, CRC is a very heterogenous set of malignancy that does not support for above criteria. Each subtype displays different pathological and genetic signatures. Based on these features...
Source: Genes and Diseases - November 22, 2019 Category: Genetics & Stem Cells Source Type: research
Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling
In this study, we recruited cell viability assay, flow cytometry analysis, cloning formation to confirm that Tet can inhibit the proliferation of SW620 cells, and induce apoptosis. Mechanically, we confirmed that Tet up-regulates the mRNA and protein level of BMP9 in SW620 cells. Over-expression BMP9 enhances the anti-cancer effects of Tet in SW620 cells, but these effects can be partly reversed by silencing BMP9. Also, Tet reduces phosphorylation of Aktl/2/3 in SW620 cells, which could be elevated by overexpressed BMP9 and impaired by silencing BMP9. Furthermore, we demonstrated that Tet reduces phosphorylated PTEN, which...
Source: Genes and Diseases - November 10, 2019 Category: Genetics & Stem Cells Source Type: research
Epigenetic regulation of prostate cancer
Publication date: Available online 9 November 2019Source: Genes & DiseasesAuthor(s): Ruixin Wang, Xiaoqi LiuAbstractProstate cancer is (PCa) the second leading cause of cancer death in males in the United State, with 174,650 new cases and 31,620 deaths estimated in 2019. It has been documented that epigenetic deregulation such as histone modification and DNA methylation contributes to PCa initiation and progression. EZH2 (enhancer of zeste homolog 2), the catalytic subunit of the Polycomb Repressive Complex (PRC2) responsible for H3K27me3 and gene repression, has been identified as a promising target in PCa. In addition, o...
Source: Genes and Diseases - November 10, 2019 Category: Genetics & Stem Cells Source Type: research
Moving into a new era --- SCIE coverage is the next rung on the ladder for Genes & Diseases
Publication date: Available online 28 October 2019Source: Genes & DiseasesAuthor(s): T.-C. He, the Editorial Board (Source: Genes and Diseases)
Source: Genes and Diseases - November 8, 2019 Category: Genetics & Stem Cells Source Type: research
An updated review on activated PI3 kinase delta syndrome (APDS)
Publication date: Available online 14 October 2019Source: Genes & DiseasesAuthor(s): Ankita Singh, Vibhu Joshi, Ankur Kumar Jindal, Babu Mathew, Amit RawatAbstractActivated Phosphoinositide 3-kinase δ syndrome (APDS) is a newly recognised primary immunodeficiency disease. It has currently been a hot topic of clinical research and new data are emerging regarding its pathogenesis, clinical manifestations and treatment. Patients with APDS syndrome have significant autoimmune manifestations and lymphoproliferation. It is important to differentiate APDS from the usual polygenic CVID in view of the availability of targeted ther...
Source: Genes and Diseases - November 3, 2019 Category: Genetics & Stem Cells Source Type: research
Proceedings of National Conference on Biotechnology Innovations (NatConBio 2019, Pradesh, India, September 27-28, 2019)
Publication date: Available online 2 November 2019Source: Genes & DiseasesAuthor(s): (Source: Genes and Diseases)
Source: Genes and Diseases - November 3, 2019 Category: Genetics & Stem Cells Source Type: research
Traditional Chinese Medicine as Supportive Care for the Management of Liver Cancer: Past, Present, and Future
Publication date: Available online 2 November 2019Source: Genes & DiseasesAuthor(s): Xia Liao, Yang Bu, Qingan JiaAbstractLiver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide. Western medicine and therapies are the primary treatment strategies of hepatocellular carcinoma (HCC), but the general prognosis for HCC patients is still dismal. Under these circumstances, HCC prevention is particularly important. Traditional Chinese medicine (TCM) encompasses a wealth of documented therapeutic resources, and “preventative treatment” is the principle of TCM. In China, TC...
Source: Genes and Diseases - November 3, 2019 Category: Genetics & Stem Cells Source Type: research
