European Journal of Cancer Supplements 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.P158
Conclusion Here we present for the first time a cross-platform mass spectrometric analysis of bile juice collected from the patients cholangiocarcinoma-associated diseases. We show that a combination of the two platforms greatly improves the coverage of the metabolome and as such should be a firstchoice for exploratory studies of the complex biological matrixes. Work was conducted with the application of the Tomsk regional common use center technical equipment acquired thanks to a grant of the Russian Ministry of the Agreement No. 14.594.21.0001 (RFMEFI59414X0001). This project is supported by “The Tomsk State University...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
A141
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): H. Davtyan, G. Hakobyan, K. Alexsanyan, Y. Tadevosyan The aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels. Eight PL fractions were identified by TLC method in the PM of MNC, namely: lysophosphatidylcholines (LPC), sphingomyelins (SPM), phosphatidylcholines (PC), phosphatidylinositols (PI), phosphatidylserines (PS), ph...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
A129
In conclusion, these data confirm previously existing assumption about paracrine effect of Igfbps on tumor growth and progression. Phosphorylation of FoxO3 protein may play an important role in survival of cancer cells. Our results showed up-regulation of Igfbp-2 and Igfbp-5 in tumor and tumor surrounding tissue. Igfbp-2 and Igfbp-5, well known activators of Igfs, can be pro-tumorigenic factors, which are important for hepatocarcinogenesis. Hence, therapeutic targeting of these proteins may offer options for intervention in human HCC. Project supported by Russian Foundation for Basic Research (Russia) No. (113-04-01459). (...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P132
Conclusions 1.It was established that in the pathogenesis of choroidal melanoma, local Inflammation plays an important role as evidenced by a significant high concentration of IL-6, IL-8 due to lower levels of IL-4 and expressed immune disorders, cell destruction, as evidenced by significantly high level of AAB to Ag of nDNA, compared with the control group. 2.Use of lacrimal liquid is suitable for the study of the inflammation, immune disorders and cell destruction at the local level in patients with choroidal melanoma. 3.Significant increase in IL-6 level in lacrimal liquid was observed for all stages of choroidal...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P133
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): A. Cherepanova, V. Vlassov, P. Laktionov The strong connection between cancer-related inflammation and tumour development with pattern – recognizing receptors (PRRs) activation results in identification of new target molecules that could lead to improved cancer diagnosis and treatment. TLR3, RIG1 and MDA5 synthetic ligand poly(I:C) was shown to trigger apoptosis in cancer cells. However, TLR3 signaling also includes NF-kB transcription factor which has emerged as endogenous tumour promoter via stimulatio...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
T93
Conclusion The parameters of the activation of systemic and intra-tumoral immune system by growing tumor and its dissemination have to be validated in order to identify the new prognostic markers for the efficiency of the neoadjuvant chemotherapy. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P131
Conclusion Our data showed that metastasis to lymph nodes and alcohol consumption are the main factors that affect mortality in HNC patients of Tomsk region. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
A111
Conclusion Quantitative changes of some components of the tumor microenvironment such as CD4+-, CD8+-, FOXP3+-lymphocytes and content of FOXP3+-tumor cells correlate with the biological characteristics of EC and apparently have a significant role in the progression of this cancer. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P67
In this study, we have investigated microvesicles and miRNA from urine of healthy donors and PCa patients. To isolate miRNAs from urine and microparticles, novel methods for miRNA isolation were elaborated (Rus. patent application No 2014137763, priority date 17.09.2014). The study population included 14 patients with PCa (63–82years, T2-3NxMx1) and control group of 20 healthy volunteers with no previous history of prostate disease (48–73years). Urine was clarified by two serial centrifugations at 400g, 20°C, 20min and at 17000g, 20°C, 20min. Microparticles were precipitated from the resulting supernatant by high-spe...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P70
Conclusion Thus, obtained candidate DNA-vaccine encoding target polyepitopeimmunogen provides synthesis of relevant protein in the eukaryotic cells culture. In future, we plan to study biological activity of DNA-vaccine to evaluate level of induction of cytotoxic response against SKBR3 breast cancer cells. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P124
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): A. Bondar, A. Kurilshikov, E. Morozkin, M. Zaripov, M. Kabilov, V. Voytsitskiy, V. Vlassov, P. Laktionov Cancer cells display altered methylation signatures distinguishing them from normal cells. Originating from all tissues and cells of the body cell-free DNA (cfDNA) including aberrantly methylated DNA reflect epigenetic aberrations occurs not only in tumor cells but also in tumor microenvironment. Actually, aberrantly methylated cfDNA has proved to be a promising biomarker for noninvasive detec...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
T116
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): B. Biedermann The work describes advantages of our latest instrument developments in flow cytometry and microscopy. Characteristics of newly launched flow cytometer, which uses acoustic focusing to align the cells in the focus of the laser for analysis, allows to analyze samples at a much higher throughput rate without losing precision and sensitivity. This opens up new possibilities regarding sample preparation and analysis. These advantages we want to demonstrate on 2 examples, whole blood analysis and rare ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
A94
Conclusion This study has shown the greater development of blood and lymphatic vessels in LLSCC without keratinization in comparison with hyperkeratosis and LLSCC with keratinization, thus contributing to the development of metastasis. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P113
Conclusion G1958A SNP in the MTHFD1 gene contributes to susceptibility to NHL. The mutant allele and genotype determine the protective effect, probably, by affecting the concentration of intracellular folic acid metabolites. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
P57
Conclusion As a first step in the development of GC riskometry was found that noninvasive set of serological biomarkers is an informative and non-expensive tool for the early detection of GC in population-based retrospective cohort survey in Siberian population. Low levels of PGI and PGI/PGII ratio were proven as the most valuable prognostic factors. The low level of G-17 as a single index did not significantly predict the risk of GC. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research
