Anti ‐inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro‐inflammatory mediators
Abstract
Inflammation is a complex biological process that is generally occurs in response to pathological triggers. Both neurodegenerative diseases and cancer have been linked to inflammation. The analgesic and anti‐inflammatory effects of cupressuflavone (CUF) isolated from Cupressus macrocarpa were examined. The analgesic effects of CUF (40, 80 and 160 mg/kg po) were assessed in the acetic acid‐induced writhing and hot plate models in mice with diclofenac sodium as the reference standard (100 mg/kg). CUF dose‐dependently inhibited the writhing response in mice by 25, 48, and 62%, at the three CUF doses with...
Source: Drug Development Research - November 1, 2017 Category: Drugs & Pharmacology Authors: Eman Al ‐Sayed, Haidy A. Gad, Mohamed El‐Shazly, Mohamed M. Abdel‐Daim, Abdel Nasser Singab Tags: Research Article Source Type: research
Free fatty acid receptor 1 agonist, MR1704, lowers blood glucose levels in rats unresponsive to the sulfonylurea, glibenclamide
Drug Development Research,Volume 79, Issue 1, Page 16-21, February 2018. (Source: Drug Development Research)
Source: Drug Development Research - October 27, 2017 Category: Drugs & Pharmacology Source Type: research
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Drug Development Research,Volume 79, Issue 1, Page 16-21, February 2018. (Source: Drug Development Research)
Source: Drug Development Research - October 27, 2017 Category: Drugs & Pharmacology Source Type: research
Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls
Drug Development Research,Volume 79, Issue 1, Page 11-15, February 2018. (Source: Drug Development Research)
Source: Drug Development Research - October 26, 2017 Category: Drugs & Pharmacology Source Type: research
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Drug Development Research,Volume 79, Issue 1, Page 11-15, February 2018. (Source: Drug Development Research)
Source: Drug Development Research - October 26, 2017 Category: Drugs & Pharmacology Source Type: research
Angelicin potentiates TRAIL ‐induced apoptosis in renal carcinoma Caki cells through activation of caspase 3 and down‐regulation of c‐FLIP expression
Drug Development Research,Volume 79, Issue 1, Page 3-10, February 2018. (Source: Drug Development Research)
Source: Drug Development Research - October 16, 2017 Category: Drugs & Pharmacology Source Type: research
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Drug Development Research,Volume 79, Issue 1, Page 3-10, February 2018. (Source: Drug Development Research)
Source: Drug Development Research - October 16, 2017 Category: Drugs & Pharmacology Source Type: research
Coenzyme Q10 Prevents the Interleukin ‐1 Beta Induced Inflammatory Response via Inhibition of MAPK Signaling Pathways in Rat Articular Chondrocytes
ABSTRACT
Osteoarthritis (OA) is a widely prevalent degenerative joint disease that severely impairs the health of the elderly population resulting in a heavy economic burden worldwide. Coenzyme Q10 (CoQ10) has shown anti‐inflammatory effects in some diseases. The present study aimed to investigate if CoQ10 would suppress catabolic responses of interleukin (IL)‐1β‐induced chondrocytes. Rat chondrocytes were cultured and pretreated with CoQ10, and then stimulated with or without IL‐1β (10 ng/ml). The expression and production of matrix metalloproteinase (MMP)‐3, MMP‐9, and MMP13 were determined using rea...
Source: Drug Development Research - September 17, 2017 Category: Drugs & Pharmacology Authors: Xing Li, Yuanqing Guo, Shuai Huang, Minhui He, Qiaoli Liu, Weizhi Chen, Minghao Liu, Dongliang Xu, Peiheng He Tags: Research Article Source Type: research
Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress ‐Induced Behavioral and Biochemical Alterations in Mouse Brain
ABSTRACT
The effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)‐induced depression‐like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed ...
Source: Drug Development Research - September 17, 2017 Category: Drugs & Pharmacology Authors: Adaeze Adebesin, Abayomi M. Ajayi, Elizabeth O. Olonode, Osarume Omorogbe, Solomon Umukoro Tags: Research Article Source Type: research
Issue Information – TOC
(Source: Drug Development Research)
Source: Drug Development Research - September 7, 2017 Category: Drugs & Pharmacology Tags: Issue Information – TOC Source Type: research
Free fatty acid receptor 1 agonist, MR1704, lowers blood glucose levels in rats unresponsive to the sulfonylurea, glibenclamide
Abstract
MR1704 is a selective G protein‐coupled receptor 40/free fatty acid receptor 1 agonist, which exhibited favorable pharmacokinetic profiles and glucose‐lowering effects in animal models. We studied the effects of MR1704 in a sulfonylurea‐desensitized Sprague–Dawley rat model and evaluated the risk of pancreatic β‐cell exhaustion compared to that of glibenclamide in Zucker fatty rats. Rats fed ad libitum a diet containing 0.03% glibenclamide exhibited lower non‐fasting blood glucose levels compared to those in rats fed a control diet during the first 6 days. However, the response to glibenclamide...
Source: Drug Development Research - September 1, 2017 Category: Drugs & Pharmacology Authors: Naoto Tsuda, Atsuko Kawaji, Mitsuhiro Takagi, Chika Higashi, Masaki Nakamura, Yoshitaka Hosaka, Junichi Sakaki Tags: Preclinical Research & Development Source Type: research
Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls
Abstract
The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol‐induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol‐induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg−1. A similar value was obtained at 10 mg kg−1 (83.5 ± 7.7%). Meanwhile, the reference anti‐ulcer drug, carbenoxolone, an 11β‐hydroxysteroid dehydrogenase (11β‐HSD) inhibitor administered at 30...
Source: Drug Development Research - September 1, 2017 Category: Drugs & Pharmacology Authors: Mar ía Elena Sánchez‐Mendoza, Yaraset López‐Lorenzo, Audifás‐Salvador Matus‐Meza, Jesús Arrieta Tags: Research Article Source Type: research
Angelicin potentiates TRAIL ‐induced apoptosis in renal carcinoma Caki cells through activation of caspase 3 and down‐regulation of c‐FLIP expression
This study provides evidence that angelicin might be a TRAIL sensitizer. (Source: Drug Development Research)
Source: Drug Development Research - September 1, 2017 Category: Drugs & Pharmacology Authors: Kyoung ‐Jin Min, Hee Jung Um, Seung Un Seo, Seon Min Woo, Shin Kim, Jong‐Wook Park, Hyun‐Shik Lee, Sang Hyun Kim, Yung Hyun Choi, Tae‐Jin Lee, Taeg Kyu Kwon Tags: Research Article Source Type: research
Synergistic Interaction of a Gabapentin ‐ Mangiferin Combination in Formalin‐Induced Secondary Mechanical Allodynia and Hyperalgesia in Rats Is Mediated by Activation of NO‐Cyclic GMP‐ATP‐Sensitive K+ Channel Pathway
ABSTRACT
Gabapentin is an anticonvulsant used to treat neuropathic pain. Mangiferin is an antioxidant that has antinociceptive and antiallodynic effects in inflammatory and neuropathic pain models. The purpose of this study was to determine the interaction between mangiferin and gabapentin in the development and maintenance of formalin‐induced secondary allodynia and hyperalgesia in rats. Gabapentin, mangiferin, or their fixed‐dose ratio combination were administrated peripherally. Isobolographic analyses was used to define the nature of the interaction of antiallodynic and/or antihyperalgesic effects of the two...
Source: Drug Development Research - September 1, 2017 Category: Drugs & Pharmacology Authors: Beatriz God ínez‐Chaparro, Geovanna Nallely Quiñonez‐Bastidas, Isabel Rocío Rojas‐Hernández, Amaya Montserrat Austrich‐Olivares, Alfonso Mata‐Bermudez Tags: Research Article Source Type: research
Is 2 ‐Hydroxypropyl‐β‐cyclodextrin a Suitable Carrier for Central Administration of Δ9‐Tetrahydrocannabinol? Preclinical Evidence
ABSTRACT
Δ9‐Tetrahydrocannabinol (THC) is a hydrophobic compound that has a potent antinociceptive effect in animals after intrathecal (IT) or intracerebroventricular (ICV) administration. The lack of a suitable solvent precludes its IT administration in humans. 2‐Hydroxypropyl‐β‐cyclodextrin (HPβCD) increases the water solubility of hydrophobic drugs and is approved for IT administration in humans. To investigate whether HPβCD might be a suitable carrier for ICV administration of THC in rats, two formulations containing THC complexed with HPβCD (30 and 135 μg of THC per animal) and vehicle were admini...
Source: Drug Development Research - September 1, 2017 Category: Drugs & Pharmacology Authors: R. Agabio, F. Sanna, C. Lobina, M. Monduzzi, V. Nairi, F. Cugia, S. Mameli, G. M. Pisanu, G. L. Gessa, M. R. Melis Tags: Research Article Source Type: research
