Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

Abstract The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol‐induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol‐induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg−1. A similar value was obtained at 10 mg kg−1 (83.5 ± 7.7%). Meanwhile, the reference anti‐ulcer drug, carbenoxolone, an 11β‐hydroxysteroid dehydrogenase (11β‐HSD) inhibitor administered at 30 mg kg−1 showed 63.5 ± 9.4% gastroprotection. Hence, calealactone B was more potent than carbenoxolone. Pretreatment with indomethacin, L‐NAME or NEM did not reverse the effects of calealactone B, indicating that prostaglandins, NO and sulfhydryl compounds do not participate in its mechanism of action.
Source: Drug Development Research - Category: Drugs & Pharmacology Authors: Tags: Research Article Source Type: research