Issue Information ‐TOC
(Source: Drug Development Research)
Source: Drug Development Research - August 31, 2016 Category: Drugs & Pharmacology Tags: Issue Information ‐TOC Source Type: research
MicroRNAs as CNS Drug Targets
(Source: Drug Development Research)
Source: Drug Development Research - August 28, 2016 Category: Drugs & Pharmacology Authors: David Gurwitz Tags: Editorial Source Type: research
Molecular Mechanism and Clinical Relevance of Ketamine as Rapid ‐Acting Antidepressant
ABSTRACT
The emergence of rapid‐acting antidepressants such as ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine antidepressant effect and to enable the clinical application of rapid‐acting antidepressants. Here, we provide an overview of studies addressing the antidepressant effects of ketamine in depressed patients and animal models of depression and we compare the reduction of depressive symptoms in humans with the reduction in immobility time in the forced swim test in rodents after acute ketamine treatment. We also discuss different theories and potential biochemical pa...
Source: Drug Development Research - August 21, 2016 Category: Drugs & Pharmacology Authors: Vesna Pe šić, Jelena Petrović, Marin M Jukić Tags: Research Overview Source Type: research
Biomarkers for Major Depressive Disorder: Economic Considerations
ABSTRACT
Major depressive disorder (MDD) is a major psychiatric illness and it is predicted to be the second leading cause of disability by 2020 with a lifetime prevalence of about 13%. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used therapeutic class for MDD. However, response to SSRI treatment varies considerably between patients. Biomarkers of treatment response may enable clinicians to target the appropriate drug for each patient. Biomarkers need to have accuracy in real life, sensitivity, specificity, and relevance to depression. Introduction of MDD biomarkers into the health care sys...
Source: Drug Development Research - August 21, 2016 Category: Drugs & Pharmacology Authors: Natasa Bogavac ‐Stanojevic, Dragana Lakic Tags: Research Overview Source Type: research
Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders
ABSTRACT
Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co‐morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolis...
Source: Drug Development Research - August 18, 2016 Category: Drugs & Pharmacology Authors: Miroslav Adzic, Zeljka Brkic, Sonja Bulajic, Milos Mitic, Marija B. Radojcic Tags: Review Source Type: research
Synthesis and Biological Evaluation of Novel Carbohydrate ‐Derived Derivatives of Erlotinib
Abstract
A series of novel carbohydrate‐derived Erlotinib derivatives were prepared by the copper‐catalyzed cycloaddition reaction of erlotinib with various azido‐sugars. The structures of the newly synthesized compounds were characterized and their cytostatic effects evaluated in vitro on human cancer cell lines MDA‐MB‐231, HEPG‐2, A549, and MCF‐7 using an MTS assay. The novel erlotinib derivatives had the expected inhibitory effects on MDA‐MB‐231 and HEPG‐2 cell llines. Among the compounds evaluated the carbohydrate‐derived compounds 5b, 5d, 6a, and 6c had more potent activities against MDA...
Source: Drug Development Research - August 12, 2016 Category: Drugs & Pharmacology Authors: Wenbo Yu, Luxia Jiang, Chao Shen, Pengfei Zhang Tags: Research Article Source Type: research
Instruction to Authors
(Source: Drug Development Research)
Source: Drug Development Research - August 5, 2016 Category: Drugs & Pharmacology Tags: Instruction to Authors Source Type: research
Issue Information ‐TOC
(Source: Drug Development Research)
Source: Drug Development Research - August 5, 2016 Category: Drugs & Pharmacology Tags: Issue Information ‐TOC Source Type: research
Benefits of Cognitive Treatments Administered to Patients Affected by Mild Cognitive Impairment/Mild Neurocognitive Disorder
ABSTRACT
Mild Cognitive Impairment (MCI) now termed Mild Neurocognitive Disorder (MCD) in DSM‐5, is widely used to define the disorder in individuals who have subjective cognitive deficits, objective memory impairments, or other cognitive deficits, without impairments in daily activities. Cognitive enhancers such as the acetylcholinesterase inhibitors, commonly used with some benefit in overt dementia, have recently started to be used in MCI/MCD. Treatment of disorders associated with cognitive dysfunction represents an expanding area of neurological rehabilitation and continues to be of paramount importance from ...
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Marco Cavallo, Arianna Signorino, Maria Luisa Perucchini Tags: Clinical Overview Source Type: research
Delivery of Antipsychotics with Nanoparticles
ABSTRACT
Psychosis remains one of the most challenging health problems for society, affecting hundreds of millions of people worldwide. Although current antipsychotics can alleviate the symptoms of psychosis, they are still far away from being perfect, often causing significant and even fatal side effects such as involuntary movement disorders and metabolic syndrome. With the lack of precise knowledge of the underlying mechanisms of psychosis, a rational approach to improve the efficiency of current antipsychotics is by nanoparticle‐based administration. Nanoparticles with the size of 1–500 nm can be used in dru...
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Yuan Sun, Chen Kang, Fei Liu, Lei Song Tags: Research Review Source Type: research
Perspectives in Designing Multifunctional Molecules in Antipsychotic Drug Discovery
ABSTRACT
A novel and promising approach to overcome the limits of single‐target therapy is represented by the multitarget approach. This strategy aims to simultaneously modulate several targets involved in the pathophysiology of a multifactorial disease, with the potential to enhance therapeutic effectiveness and improve drug safety. Although there has been a marked growth in the design of multitarget drugs (MTDs) in the last years in the context of anti‐Alzheimer and anti‐cancer drug discovery, a parallel expansion was not observed in antipsychotic drugs, even that for psychiatric disorders there is a cogent ...
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Andrea Milelli, Eleonora Turrini, Elena Catanzaro, Francesca Maffei, Carmela Fimognari Tags: Research Review Source Type: research
Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress ‐Induced Damage via Induction of Nrf‐2‐Mediated HO‐1 Expression
ABSTRACT
The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2O2)‐induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO‐1 pathway. BBH preconditioning attenuated H2O2‐induced growth inhibition and DNA damage as well as apoptosis in C2C12 cells via suppression of the accumulation of intracellular reactive oxygen species (ROS). Treatment with BBHride alone effectively upregulated th...
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Yung Hyun Choi Tags: Research Article Source Type: research
Combination of Vildagliptin and Pioglitazone in Experimental Type 2 Diabetes in Male Rats
ABSTRACT
The majority of studies on vildagliptin and pioglitazone have focused on their combination in glycemic control. The aim of the present study was to investigate their effects in combination on (i) hyperglycemia‐induced oxidative stress and inflammation and (ii) on organs involved in the pathophysiology of diabetes, pancreas, kidney and liver. Type 2 diabetes was induced using low‐dose streptozotocin in male Wistar rats. Diabetic rats were treated for 4 weeks, with vildagliptin (10 mg/kg/day), pioglitazone (10 mg/kg/day) and their combination. Diabetic rats showed elevated fasting serum glucose, fasting s...
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Rowaida Refaat, Ahmed Sakr, Mona Salama, Ashgan El Sarha Tags: Research Article Source Type: research
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat
In conclusion, this study shows that metformin has a potential for use in treating various inflammatory conditions. (Source: Drug Development Research)
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Abhimanu Pandey, Vijay L. Kumar Tags: Research Article Source Type: research
Issue Information ‐TOC
(Source: Drug Development Research)
Source: Drug Development Research - June 8, 2016 Category: Drugs & Pharmacology Tags: Issue Information ‐TOC Source Type: research
