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Evaluation of graft and recipient risk factors in liver transplantation
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): P. Burra , E. De Martin , M. Senzolo Donor–recipient matching is an important factor influencing the outcome of liver transplantation (LT), especially when, due to organ shortage, extended criteria donors (ECD) are used. Among donor risk factors, donor age has been associated with severe HCV recurrence after LT, and severe steatosis increases the risk of NAFLD after LT and impairs liver regeneration when partial liver is used. Grafts from HCV positive donors can be used (in absence of fibrosis) in HCV posit...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

De-novo hepatitis B virus infection in transplants: Risk factors and anti-hepatitis B immunoglobulin prophylaxis
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): A. Marzano The dramatic increase of transplantation activity in the last years has been related to the increase of eligible donors and to the use of “marginal grafts” from aged donors or even from hepatitis B virus (HBV) infected patients in emergencies. Hepatitis B after transplantation is related to the appearance of HBsAg in subjects originally positive (reactivation) or negative (de-novo hepatitis B, DNHB). DNHB can be influenced by: a) transmission from donors who are carriers of occult B infection (OB...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Prevention of HBV recurrence after liver transplant: The role of combination therapy
In conclusion, the prophylaxis of HBV re-infection combining antiviral therapy prior to transplantation, and combination of HBIG and antiviral therapy post-transplantation is effective in reducing the rate of HBV re-infection. (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Pool expansion for organ procurement: Older donors for liver transplantation
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): F. Filipponi Graft survival is influenced by donor age especially in the long term. Use of grafts from elderly donors (ED) for liver transplantation is increasing in Europe and the US. ED have to be included in the category of extended criteria donor (ECD) grafts, with a risk of allograft failure, poor graft function and transmissible disease. Various attempts to quantify the risk associated with ECD in solid organ transplantation such as the donor risk index (DRI) have been made over the last years. The widesp...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Split and living donor liver transplantation
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): J.C. García-Valdecasas The split liver transplant allows for the division of a graft in two parts, usually the right side for an adult and the left side for use in a child. To date, many centres have confirmed the efficacy and safety of the procedure. However, the highly demanding surgery and the relatively low activity, associated with the low number of ideal donors, and few adequate recipients, and most of all, the compromised long-term outcome, have resulted in a significant decrease of adult to adult split...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Benefit and harm of deceased- or living-donor liver transplantation for hepatocellular carcinoma
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): U. Cillo , A. Vitale The decision to allocate a given organ from a deceased (DD) or living donor (LD) to a particular recipient awaiting liver transplantation (LT) is strongly influenced by ethical and health policy issues. The liver transplant community is currently discussing several ethical principles with a view to improving the allocation process as a whole. These principles are: urgency, utility, intention-to-treat survival, transplant benefit, harm to candidates on waiting list (WL), harm to living dono...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Liver transplantation from donors after cardiac death
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): C. Fondevila , J.C. García-Valdecasas Organ shortage limits the applicability of liver transplantation to treat end-stage liver disease, and the use of extended-criteria donors is a necessity in the current era. Donors after cardiac death (DCD) suffer irreversible cardiac arrest prior to donation and represent a potential source of additional organs if properly maintained. DCD undergo an initial period of warm ischemia that provokes cellular alterations. Experimental and clinical studies performed at our cent...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Liver transplantation: The Spanish experience
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): R. Matesanz , G. de la Rosa Liver transplant activity started in Spain in 1984 and has reached 16,132 interventions at 31st December 2008, with a mean activity of more than 1000 transplants during the last years. There are 25 transplant teams (1/1.85 million inhabitants), two of them paediatric. The maximum activity has been recorded at the Hospital La Fe (Valencia) with 1,557 transplants (more than 100 annually). The majority were standard deceased donor transplants. Other modalities were: 222 living donors (...
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Liver Transplantation Interdisciplinary Conference (2)
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): Mario Rizzetto (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Liver Transplantation Interdisciplinary Conference (1)
Publication date: December 2009 Source:Digestive and Liver Disease Supplements, Volume 3, Issue 4 Author(s): Vicente Arroyo (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Adalimumab in a patient with steroid-dependent Crohn's disease
We present the case of 51-year-old man with stricturing Crohn's disease of the jejunum and ileum who underwent jejunal resection and creation of a latero-lateral anastomosis. The patient had a history of steroid-dependent disease and was inappropriately treated with azathioprine, complicated by vertebral collapse. Adalimumab administered subcutaneously was used because of the persistence of active disease. (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Combined treatment with adalimumab and surgery in a patient with steroid-dependent Crohn's disease complicated by perianal disease
Publication date: December 2010 Source:Digestive and Liver Disease Supplements, Volume 4, Issue 1 Author(s): Sara Renna , Ambrogio Orlando , Gaspare Solina , Mario Cottone (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Adalimumab and perianal Crohn's disease: Case report
Publication date: December 2010 Source:Digestive and Liver Disease Supplements, Volume 4, Issue 1 Author(s): Mariabeatrice Principi , Nicola De Tullio , Alfredo di Leo (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Steroid-free remission and closure of recto-vaginal fistula using adalimumab in a Crohn's disease patient naïve to anti-tumour necrosis factor alpha antibodies
Publication date: December 2010 Source:Digestive and Liver Disease Supplements, Volume 4, Issue 1 Author(s): Sara Onali , Francesca Zorzi , Emma Calabrese , Livia Biancone (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research

Adalimumab is effective in achieving clinical and endoscopic long-term deep remission: A case report
We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery. (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - November 2, 2014 Category: Gastroenterology Source Type: research