Prevention of post-surgical recurrence with adalimumab in a patient with complicated Crohn's disease
Publication date: December 2010Source: Digestive and Liver Disease Supplements, Volume 4, Issue 1Author(s): Giuseppe Costantino, Giuseppe Navarra, Luigi Familiari, Walter Fries (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Adalimumab is effective in achieving clinical and endoscopic long-term deep remission: A case report
We report the case of a 61-year-old woman with aggressive and complicated steroid-dependant Crohn's disease in whom clinical and endoscopic long-term deep remission was achieved for up to 3 years, without any need for steroids, hospitalization or surgery. (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Steroid-free remission and closure of recto-vaginal fistula using adalimumab in a Crohn's disease patient naïve to anti-tumour necrosis factor alpha antibodies
Publication date: December 2010Source: Digestive and Liver Disease Supplements, Volume 4, Issue 1Author(s): Sara Onali, Francesca Zorzi, Emma Calabrese, Livia Biancone (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Adalimumab and perianal Crohn's disease: Case report
Publication date: December 2010Source: Digestive and Liver Disease Supplements, Volume 4, Issue 1Author(s): Mariabeatrice Principi, Nicola De Tullio, Alfredo di Leo (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Combined treatment with adalimumab and surgery in a patient with steroid-dependent Crohn's disease complicated by perianal disease
Publication date: December 2010Source: Digestive and Liver Disease Supplements, Volume 4, Issue 1Author(s): Sara Renna, Ambrogio Orlando, Gaspare Solina, Mario Cottone (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Adalimumab in a patient with steroid-dependent Crohn's disease
We present the case of 51-year-old man with stricturing Crohn's disease of the jejunum and ileum who underwent jejunal resection and creation of a latero-lateral anastomosis. The patient had a history of steroid-dependent disease and was inappropriately treated with azathioprine, complicated by vertebral collapse. Adalimumab administered subcutaneously was used because of the persistence of active disease. (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Editorial Board
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

2nd Liver Transplantation, HBV and HCV Interdisciplinary Conference
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Rafael Esteban, Franco Filipponi (Source: Digestive and Liver Disease Supplements)
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Current challenges and future trends in liver transplantation
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Manuel L. Rodríguez-Perálvarez, Jose Luis Montero, Manuel De la Mata GarcíaAbstractIn Liver Transplantation (LT) units the clinicians routinely deal with complex decision making situations that cannot always be solved with the available scientific evidence. They include selection of the best candidates for LT, minimizing mortality and drop-out rates within the waiting list (WL) and rationalizing donor–recipient matching. These topics constitute some of the current challenges in LT and they may drive a number of ...
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Liver transplantation: is it a sustainable practice?
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Franco FilipponiAbstractDespite its widespread diffusion, liver transplantation (LT) still remains one of the most resource consuming surgical procedures. In times of economic constraints, the entire medical community is discussing the strategies necessary to allow a sustainable development of LT. Sustainability is the capacity to endure and, in ecology, the word describes how biological systems remain diverse and productive over time. In clinical practice, sustainability is the potential for long-term maintenance of...
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Management of hepatitis B virus infection in the pre-transplant setting
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Martín Prieto, María García-ElizAbstractLiver transplantation remains the ultimate cure for patients with hepatitis B virus-related end-stage liver disease. Clinical Practice Guidelines currently recommend that patients with decompensated HBV cirrhosis should be treated without delay with nucleos(t)ide analogues regardless of the patient's serum ALT, HBV DNA level, and HBeAg status. The main goal of pre-transplantation antiviral therapy is to achieve a rapid and prolonged suppression of viral replication and thus ...
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Optimization of hepatitis B virus prophylaxis after liver transplantation
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Paolo De SimoneAbstractA combination of hepatitis B immunoglobulins (HBIg) and nucleos(t)ide analogues (NA) is currently recommended for HBV prophylaxis after liver transplantation (LT), but the optimal regimen is still controversial. Several issues concerning use of HBIg after LT still await definitive clarification, such as dosage (high vs. low); timing (ab initio vs. delayed); schedule (on demand vs. fixed-dose); route of administration (intravenous vs. intramuscular vs. subcutaneous), and duration (short-term vs....
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Management of HBV resistance in the post-transplant setting
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Alfredo MarzanoAbstractIn western countries, about 10–25% of patients undergoing liver transplantation (LT) are HBsAg carriers. In Asia, HBV-related liver disease is the leading indication to LT. After surgery hepatitis B can develop in patients transplanted for HBV-related disease or in HBsAg-negative recipients of anti-HBc positive grafts. In the last years prophylaxis with HBIG and/or antivirals has been proposed in both conditions with excellent results. However, lack of efficacy of prophylaxis is frequently as...
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Non-invasive diagnosis of liver fibrosis in the transplant setting
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Gonzalo Crespo, Zoe MariñoAbstractRecurrent hepatitis C after liver transplantation is a rapidly evolving condition in which fibrosis deposition is accelerated, with 30% of patients developing graft cirrhosis within the first 5 years after transplantation. Antiviral therapy after transplantation achieves sustained virological response (SVR) in approximately 30% of patients, and a milder fibrosis stage at treatment seems to increase the probabilities of response to treatment. Importantly, SVR to antiviral therapy in ...
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research

Treatment of hepatitis C in the post-transplant setting
Publication date: December 2011Source: Digestive and Liver Disease Supplements, Volume 5, Issue 1Author(s): Marina BerenguerAbstractCirrhosis with/without hepatocellular carcinoma is the primary indication for liver transplantation (LT) in many countries. Hepatitis C virus (HCV) reinfection occurs universally resulting in HCV-graft disease with progression to cirrhosis in about one third of cases after 5 years. Graft failure secondary to recurrent HCV is now the most frequent cause of death, graft failure and need for retransplantation in these patients, with a cumulative risk of allograft failure due to recurrent disease ...
Source: Digestive and Liver Disease Supplements - July 5, 2018 Category: Gastroenterology Source Type: research