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Strategies to enhance productivity and modify product quality in therapeutic proteins
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Devesh Radhakrishnan, Evan A Wells, Anne Skaja RobinsonThe production of commercially valuable biotherapeutic molecules in mammalian systems has expanded significantly in the last thirty years, but growing economic pressures within the industry are driving efforts to reduce costs and enhance process yields. At the upstream stage, two complementary approaches have evolved to increase productivity and maintain consistent product quality, that is either by altering the cell directly or by manipulating its environment. This revi...
Source: Current Opinion in Chemical Engineering - October 9, 2018 Category: Chemistry Source Type: research

From media to mitochondria–rewiring cellular energy metabolism of Chinese hamster ovary cells for the enhanced production of biopharmaceuticals
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Paul S Kelly, Antonio Alarcon Miguez, Christina Alves, Niall BarronMeeting the metabolic demands of Chinese hamster ovary (CHO) cells has been an area of intense investigation over the last 3 decades as a means to improve these cell factories as producers of high quality recombinant therapeutic proteins. Metabolically, the cultivation of CHO cells is characterised by the rapid consumption of the primary carbon and energy sources, glucose and glutamine, with lactate and ammonia produced as by-products, respectively. In the co...
Source: Current Opinion in Chemical Engineering - October 6, 2018 Category: Chemistry Source Type: research

Mechanistic modeling and applications for CHO cell culture development and production
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Sha Sha, Zhuangrong Huang, Zhao Wang, Seongkyu YoonChinese hamster ovary (CHO) cell cultures are widely used to produce biologics in the biopharmaceutical industry. The biopharmaceutical industry requires to improve the efficiency of process development as a response to the increasing market competition. The traditional approaches to optimize cell culture are typically empirically-based and generally time-consuming. The use of mechanistic models can be beneficial to these industrially relevant exercises and improve the effic...
Source: Current Opinion in Chemical Engineering - October 6, 2018 Category: Chemistry Source Type: research

Transformation of biomanufacturing by single-use systems and technology
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Gregory T FrankBiomanufacturing has been and continues to be transformed by the rapid innovation and adoption of single use technology (SUT). SUT has changed how bioprocesses are designed, scaled, operated, controlled, and the speed at which new technology can be incorporated into biomanufacturing. We are continually seeing advances in single use bioreactors, mixing vessels, harvest technology, and downstream bioprocess equipment. This transformation has not been limited to bioprocess equipment. In this contribution, a summa...
Source: Current Opinion in Chemical Engineering - October 6, 2018 Category: Chemistry Source Type: research

Media formulation optimization: current and future opportunities
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Shaun C. Galbraith, Hemlata Bhatia, Huolong Liu, Seongkyu YoonChemically defined cell culture media is a complex mixture of molecules used for cellular metabolism and growth. Decisions surrounding which molecules to include in a formulation and their optimal concentration is a major endeavor in biomanufacturing. Cellular metabolic complexity and stringent quality requirements that vary across cell lines require time-consuming, iterative experimentation to optimize media formulation. Exacerbating this is the orders-of-magnitu...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Dynamic process intensification
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Michael Baldea, Thomas F EdgarMost process intensification research and its applications have focused on process and equipment design modifications. In this paper, we present an overview of existing developments and opportunities in dynamic process intensification (DI), which comprises changes to dynamics, operational and control of a chemical process, that result in substantial efficiency improvements. After reviewing a series of examples, we identify several fundamental principles underlying DI, including equipment design ...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Recent advances in iron-based high-temperature water-gas shift catalysis for hydrogen production
Publication date: September 2018Source: Current Opinion in Chemical Engineering, Volume 21Author(s): Devaiah Damma, Panagiotis G SmirniotisThe high-temperature water-gas shift (HT-WGS) has received tremendous interest for the production of clean hydrogen in large scale. Iron-based oxide catalysts are widely studied for the HT-WGS reaction due to their high activity, durability, and relatively low manufacturing costs. In this review, we discussed the recent findings, especially, the role of different promoters on the HT-WGS performance of the Fe-based oxides catalyst. The review reported the recent attempts to replace the t...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Adoptive T cell therapy: engineering and biomanufacturing chimeric antigen receptor-T cell
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Jackson Jenkins, Jaeyoung Park, Kristen Petersen, Kahmil Shajihan, Srivalli Kruthiventi, Michael BetenbaughDevelopment of Chimeric Antigen Receptor (CAR)-T cells is revolutionizing the field of cell therapy. Since its inception, research has been focused on improving the effectiveness, accessibility, and safety of CAR-T cell therapy. To achieve this, the biomanufacturing process must be scaled and optimized to match increasing demand. The current processes of engineering, activating, expanding, and purifying CAR-T cells have...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Cell culture media analysis using rapid spectroscopic methods
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Alan G RyderCell culture media (CCM) used in industrial biotechnology are complex mixtures of molecules and elements that are inherently difficult to analyze comprehensively. CCM quality analysis is of utmost importance for efficient production of protein-based therapeutics with the correct Critical Quality Attributes (CQAs). Here we discuss the use of rapid spectroscopic methods for routine screening of CCM molecular variance which include electronic (UV–vis absorption and fluorescence) and vibrational (Raman, FT-IR, and ...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Process integration and control in continuous bioprocessing
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Anurag S Rathore, Nikhil Kateja, Devashish KumarBiopharmaceutical industry is presently facing multiple economic, political and regulatory challenges. The adoption of continuous bioprocessing is expected to partly alleviate these. Over the years, many technology solutions have been developed for various biotech unit operations which were hitherto operated in batch fashion. The next challenge is to integrate all unit operations to create a fully continuous manufacturing system. In this article, we discuss recent developments ...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Advances in process control strategies for mammalian fed-batch cultures
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Joon Chong Yee, Matthew S Rehmann, Grace Yao, Steven W Sowa, Kathryn L Aron, Jun Tian, Michael C Borys, Zheng Jian LiGraphical abstractAdvanced process monitoring in biologics manufacturing has been an important utility for enhancing process consistency to generate desirable and consistent product quality. The integration of Process Analytical Technology (PAT) in real-time monitoring of bioprocesses has been a focus of process research in the past decade to meet the paradigm of quality by design (QbD). This review article de...
Source: Current Opinion in Chemical Engineering - October 5, 2018 Category: Chemistry Source Type: research

Hydrogen purification with CO2-selective facilitated transport membranes
Publication date: September 2018Source: Current Opinion in Chemical Engineering, Volume 21Author(s): Witopo Salim, W.S. Winston HoH2 is an important industrial gas, and high purity H2 is required for applications. Recent advances in both H2-selective and CO2-selective membranes for H2 purification are reviewed with an emphasis on the development of CO2-selective facilitated transport membranes for H2 purification. With CO2-selective facilitated transport membranes, examples of high-pressure and low-pressure H2 purification applications are discussed. In high-pressure H2 purification in the Integrated Gasification Combined ...
Source: Current Opinion in Chemical Engineering - September 19, 2018 Category: Chemistry Source Type: research

Towards next generation CHO cell line development and engineering by systems approaches
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Jong Kwang Hong, Meiyappan Lakshmanan, Chetan Goudar, Dong-Yup LeeChinese hamster ovary (CHO) cells are the most prevalent mammalian cell factories for producing therapeutic biologics, due to its capacity for complex post-translational modifications, ability to grow well in suspension cultures and low susceptibility to human viral infections. Significant advances in various modules of the CHO cell line development and engineering (CLD&E) have contributed to up to 100-fold increase in the product yields over the last three de...
Source: Current Opinion in Chemical Engineering - September 19, 2018 Category: Chemistry Source Type: research

Editorial overview: Biotechnology and bioprocess engineering
Publication date: Available online 2 November 2017Source: Current Opinion in Chemical EngineeringAuthor(s): Nigel Titchener-Hooker (Source: Current Opinion in Chemical Engineering)
Source: Current Opinion in Chemical Engineering - July 11, 2018 Category: Chemistry Source Type: research

Editorial overview: Process systems engineering: A chemical engineering perspective of the food–energy–water nexus
Publication date: Available online 22 November 2017Source: Current Opinion in Chemical EngineeringAuthor(s): Dale L Keairns, Mahmoud El-Halwagi, Ka Ming Ng (Source: Current Opinion in Chemical Engineering)
Source: Current Opinion in Chemical Engineering - July 11, 2018 Category: Chemistry Source Type: research