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Coupling between adsorption and mechanics (and vice versa)
Publication date: June 2019Source: Current Opinion in Chemical Engineering, Volume 24Author(s): Matthieu VandammeAdsorption can deform porous solids, and mechanical stresses or strains can impact the adsorption process: this mini-review is dedicated to this coupling. After introducing some frameworks used to predict adsorption-induced strains, the question of how important it is to take into account the impact of mechanics on the adsorption process is addressed. Finally, some specific complexities (e.g. of the microstructure, or of the mechanical behavior of the adsorbent) that the community aims at integrating into the pr...
Source: Current Opinion in Chemical Engineering - January 24, 2019 Category: Chemistry Source Type: research

Kinetic Monte Carlo approach for molecular modeling of adsorption
Publication date: June 2019Source: Current Opinion in Chemical Engineering, Volume 24Author(s): Eugene UstinovNumerical modeling of various processes is widely used in chemical engineering. One of traditionally used tools applied for equilibrium systems is Monte Carlo method that utilizes ensemble averaging of functions to be determined. An alternative approach, kinetic Monte Carlo (kMC) method, was developed in the 1960s for non-equilibrium systems to study diffusion, chemical reactions, crystal growth, and so on. Recently it became evident that kMC is very efficient in simulation of equilibrium systems and has some advan...
Source: Current Opinion in Chemical Engineering - January 20, 2019 Category: Chemistry Source Type: research

Optimal operation and control of intensified processes — challenges and opportunities
Publication date: Available online 14 January 2019Source: Current Opinion in Chemical EngineeringAuthor(s): Lisia S Dias, Marianthi G IerapetritouProcess systems engineering (PSE) tools can be utilized to enable the optimal operation and control of intensified processes. In this work, the challenges in the control of intensified processes are summarized, including the difficulties in modelling and performing online optimization of these highly complex dynamic systems. Nevertheless, PSE progress in the areas of nonlinear programming, reduced-order modeling, development of software tools, parallel computing and artificial in...
Source: Current Opinion in Chemical Engineering - January 15, 2019 Category: Chemistry Source Type: research

Distributed decision making for intensified process systems
Publication date: Available online 9 January 2019Source: Current Opinion in Chemical EngineeringAuthor(s): Prodromos Daoutidis, Andrew Allman, Shaaz Khatib, Manjiri A Moharir, Matthew J Palys, Davood Babaei Pourkargar, Wentao TangProcess intensification can afford considerable benefits with respect to economics, sustainability and/or safety but also presents increased decision making challenges with respect to computational efficiency and flexibility across multiple temporal and spatial scales. Distributed decision making, that is, localized yet coordinated decision making among constituent subsystems, is a promising appro...
Source: Current Opinion in Chemical Engineering - January 10, 2019 Category: Chemistry Source Type: research

Editorial overview: Latest Advances and Current Challenges in Biomanufacturing
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Chetan Goudar, Kevin McFarland, Michael Betenbaugh (Source: Current Opinion in Chemical Engineering)
Source: Current Opinion in Chemical Engineering - December 20, 2018 Category: Chemistry Source Type: research

Publisher's Note
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): (Source: Current Opinion in Chemical Engineering)
Source: Current Opinion in Chemical Engineering - December 20, 2018 Category: Chemistry Source Type: research

Editorial Overview: Hydrogen Energy; Sources and Various Issues
Publication date: September 2018Source: Current Opinion in Chemical Engineering, Volume 21Author(s): Vasilios Manousiouthakis, Heriberto Cabezas (Source: Current Opinion in Chemical Engineering)
Source: Current Opinion in Chemical Engineering - December 12, 2018 Category: Chemistry Source Type: research

Editorial Overview: Time, Complexity, and Chemical Engineering
Publication date: September 2018Source: Current Opinion in Chemical Engineering, Volume 21Author(s): Guy B. Marin, Gregory S. Yablonsky (Source: Current Opinion in Chemical Engineering)
Source: Current Opinion in Chemical Engineering - December 12, 2018 Category: Chemistry Source Type: research

Biopharmaceutical raw material variation and control
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Jason Dickens, Sarwat Khattak, Thomas E Matthews, Dave Kolwyck, Kelly WiltbergerThe current paradigm for raw material control in the biopharmaceutical industry remains a combination of compendial tests, function-based test and engineering controls. Moreover, ad hoc scale-down process studies remain the de facto approach to understand raw material variation challenges. The biopharmaceutical industry, however, continues to experience the impact of raw material variation are current approaches are insufficient to assess key raw...
Source: Current Opinion in Chemical Engineering - December 11, 2018 Category: Chemistry Source Type: research

Model-based tools for optimal experiments in bioprocess engineering
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Vinzenz Abt, Tilman Barz, Nicolay Cruz, Christoph Herwig, Paul Kroll, Johannes Möller, Ralf Pörtner, René SchenkendorfCurrently applied methods for characterization and optimization of bio-pharmaceutical processes are still strongly empirical. This often involves Design of Experiment (DoE) methods that require a large number of time-consuming experiments and can hardly fulfill the requirements of ‘Quality by Design’ (QbD). Linking mathematical models with experimental methods is seen as an efficient strategy that sign...
Source: Current Opinion in Chemical Engineering - December 11, 2018 Category: Chemistry Source Type: research

Advancing manufacture of human mesenchymal stem cells therapies: technological challenges in cell bioprocessing and characterization
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Margarida Serra, Bárbara Cunha, Cristina Peixoto, Patrícia Gomes-Alves, Paula M AlvesThe use of human mesenchymal stem/stromal cells (hMSC) in clinical trials has been exponentially increasing over the last decade. To meet the high-growth demand for high quality hMSC products, much research and many reports have been published on bioprocess development for hMSC production in bioreactors, their downstream processing and on the development of analytical tools for standardization and harmonization of functional assays to asse...
Source: Current Opinion in Chemical Engineering - December 8, 2018 Category: Chemistry Source Type: research

Intensification of large-scale cell culture processes
Publication date: Available online 7 December 2018Source: Current Opinion in Chemical EngineeringAuthor(s): Martin Jordan, Nicola Mac Kinnon, Vincent Monchois, Matthieu StettlerManufacturers of recombinant proteins frequently face the challenge to satisfy the market needs with existing large scale production capacity. For fed-batch processes, the maximal capacity is given in yield per batch multiplied by the number of runs that can be done per year, thus strongly depending on the duration of the fed-batch run. This short review is focused on starting the fed-batch at high seeding densities, reducing the duration of the fed...
Source: Current Opinion in Chemical Engineering - December 8, 2018 Category: Chemistry Source Type: research

Process synthesis and design methods for process intensification
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Mirko SkiborowskiThe concept of process intensification (PI) focusses on the creation of safe and compact energy and cost effective technologies and processes for a more sustainable chemical industry. It has let to the development of many innovative technologies and process concepts, which gain increasing interest in academia and industry. While PI provides tremendeous opportunities, it also presents a significant challenge for process engineers, as they have to handle a steadily increasing portfoliot of options during proce...
Source: Current Opinion in Chemical Engineering - November 29, 2018 Category: Chemistry Source Type: research

How adaptive evolution reshapes metabolism to improve fitness: recent advances and future outlook
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Christopher P Long, Maciek R AntoniewiczAdaptive laboratory evolution (ALE) has emerged as a powerful tool in basic microbial research and strain development. In the context of metabolic science and engineering, it has been applied to study gene knockout responses, expand substrate ranges, improve tolerance to process conditions, and to improve productivity via designed growth coupling. In recent years, advancements in ALE methods and systems biology measurement technologies, particularly genome sequencing and 13C metabolic ...
Source: Current Opinion in Chemical Engineering - November 28, 2018 Category: Chemistry Source Type: research

Engineering of the cellular translational machinery and non-coding RNAs to enhance CHO cell growth, recombinant product yields and quality
Publication date: December 2018Source: Current Opinion in Chemical Engineering, Volume 22Author(s): Davide Vito, C Mark SmalesChinese hamster ovary cells are the main mammalian cell expression system currently used for the production of recombinant protein biopharmaceuticals. One of the key processes determining the achievable biomass of cells in the bioreactor and the yield and quality of recombinant protein from such systems is mRNA translation. Translation is the process by which ribosomes and associated cellular machinery decode an mRNA to produce a polypeptide. In recent years the roles of different classes of non-cod...
Source: Current Opinion in Chemical Engineering - November 28, 2018 Category: Chemistry Source Type: research