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(Source: Current Immunology Reviews)
Source: Current Immunology Reviews - June 14, 2018 Category: Allergy & Immunology Source Type: research
Acknowledgements to Reviewers
(Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
IL-27: Friend or Foe in the Autoimmune Diseases
Conclusions: The functions of IL-27 are currently unclear because it appears to affect different cells, cytokines, and signaling pathways differently. Further investigations are needed to clarify the role of IL-27 in autoimmune diseases. Hence, this article reviewed the multiple roles of IL-27 in autoimmune diseases and describe the influence of IL-27 on the immune system. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
Electro-Optical Assays for Immunoindication of Microbial Cells
Conclusion: The suggested electro-optical method can be recommended for analyzing of mixed cell suspensions (detection of bacterial cells in liquid phase) by using specific antibodies with further registration of their interactions measuring changes of electro-optical parameters, but without immobilization of antibodies on the solid surface (various kinds of plates). (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
The Application of Aptasensors for the Aging Diseases Diagnosis
Conclusion: This paper reveals the potential application of aptasensors as a rapid point-of-care technology for the early aging-associated disease immunodiagnostics. Thus, the aptasensors would be used in the clinical practice for the elderly healthcare. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
Dendritic Cells and Immunomodulation: Role in Health and Disease
Conclusions: The emergence of new classes of T-helper effector cells and their cytokines has led to a change in our understanding of therapeutic potentials of DCs. This has provided both new options and challenges for researchers involved in this field, and is likely to result in advancement in identifying and developing novel therapeutic measures and innovative strategies for several immunological chronic disorders. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
Endothelial Function and Pathogenesis of Endothelial Dysfunction
Conclusion: The present review intends to clarify the mechanisms behind the development of endothelial dysfunction, and aims to show how widely proven is the correlation between endothelial dysfunction (assessed both by Endo-PAT and sphigmoCOR) and cardiovascular diseases, such as atherosclerosis, hypertension, diabetes mellitus, stroke, coronary artery disease and heart failure. Moreover, the assessment of endothelial dysfunction may represent an integral adjuvant test to identify the predisposed patients at risk for future cardiovascular accidents, as we suggest. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
The Neonatal Immune System: General Concepts and Clinical Correlations
Conclusion: Nearly every component of the neonatal immune system shows differences from adults. As research progresses, a clearer understanding of the mechanisms of neonatal immune suppression will allow for the development of therapeutic interventions to help neonates overcome serious infections. (Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
Meet Our Associate Editor
(Source: Current Immunology Reviews)
Source: Current Immunology Reviews - January 12, 2018 Category: Allergy & Immunology Source Type: research
Leishmania Heat Shock Proteins as Effectors of Immune Evasion and Virulence
Historically, heat shock proteins were seen foremost as playing roles in stress protection and short term adaption to changing environmental parameters. This view is now superseded by findings that implicate HSPs in various aspects of cell regulation, protein maturation and modulation, immune response and immune modulation. Likewise in parasitic protozoa, the old view of HSPs as protecting the pathogens against the harsh conditions inside mammalian hosts has given way to a far broader picture in which parasite HSPs play decisive regulatory roles in primitive protozoa, regulating cell cycle, life cycle, morphology and prote...
Source: Current Immunology Reviews - September 6, 2017 Category: Allergy & Immunology Source Type: research
Regulatory Role of Heat Shock Proteins in the Pathogenesis of Type 1 and Type 2 Diabetes
Diabetes is a severe metabolic disorder characterized by hyperglycemia due to defects in insulin secretion and/or insulin action. Over the past decades, a continuous rise of the incidence of diabetes is observed, leading to epidemic dimensions of the disease in large parts of the western world. Depending on the type of diabetes, (auto-)immune processes (type 1 diabetes) or metabolic disorders (type 2 diabetes) dominate the pathogenesis of the disease. Therefore, investigations aiming at the identification of disease mechanisms and the development of preventive and therapeutic approaches, focus on the identification of comm...
Source: Current Immunology Reviews - September 6, 2017 Category: Allergy & Immunology Source Type: research
Role of Heat Shock Proteins in Atherosclerosis and Atrial Fibrillation
Heat Shock Proteins (HSPs) are a group of highly conserved molecular chaperones that play important roles in homeostasis and the cellular response to stress. In the cardiovascular system, HSPs maintain vessel wall integrity and cardiomyocyte function; they may be upregulated and translocated to the cell surface in response to environmental stressors. HSPs contribute to the inflammatory processes that mediate the development of atherosclerosis by activating the innate and adaptive immune response. Misdirected autoimmune attack of surface HSPs on stressed vascular endothelial cells by circulating anti-Hsp60 antibodies lead t...
Source: Current Immunology Reviews - September 6, 2017 Category: Allergy & Immunology Source Type: research
The Role of the Chaperone Grp94/Gp96 in the Intestinal Barrier and Innate Immune Functions
Heat shock proteins (HSPs) play an important role in innate immune function of the intestinal mucosa and in the barrier function of intestinal epithelial cells. Among the HSPs expressed in epithelial cells, as well as cells of the innate immune system is Grp94/Gp96. Differences in protein expression of Gp96 have been observed in patients with inflammatory bowel disease (IBD), suggesting that this chaperone may be important in this pathology. The role that Gp96 plays seems to be different depending on the cell type where it is expressed. In epithelial cells, Gp96 is recognized by pathogenic bacteria and allows bacterial inv...
Source: Current Immunology Reviews - September 6, 2017 Category: Allergy & Immunology Source Type: research
Collaboration of Heat Shock Protein 70 and Stress-induced NKG2D Ligands in the Activation of NK Cells against Tumors
The stress-inducible heat shock protein 70 (HSP70) contributes to the cellular stress response that protects cells from adverse environmental conditions. HSP70 can block apoptosis and other types of cell death induced by various stimuli. In malignant cells, the expression of HSP70 is frequently elevated and some cancers even depend on HSP70 overexpression to maintain their malignant phenotype. Extracellular HSP70 in contrast, provides a danger signal to the immune system and may activate anti-tumor immune responses by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. HSP70-activated NK cells, for example, can at...
Source: Current Immunology Reviews - September 6, 2017 Category: Allergy & Immunology Source Type: research
HSP60 is a Ubiquitous Player in the Physiological and Pathogenic Interactions between the Chaperoning and the Immune Systems
HSP60 participates in many interactions between the system integrated by all chaperones and closely associated molecules (chaperoning system or CS) and the immune system (IS). These interactions occur constantly to maintain normal cell physiology but, occasionally, they are perturbed and become mediators of pathologic events that may lead to disease. This switch to pathology may be initiated by various factors, genetic or acquired, which cause qualitative and/or quantitative modifications of HSP60, or immune crossreactivity between the human and microbial chaperonin orthologs, or a break in the balance between the pro- and...
Source: Current Immunology Reviews - September 6, 2017 Category: Allergy & Immunology Source Type: research
