Explaining the Obesity Paradox--Letter
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Winkels, R. M., van Zutphen, M., Kampman, E., van Baar, H., Beijer, S. Tags: Letter to the Editor Source Type: research

The Prevalence of Cancer-Associated Autoantibodies in Patients with Gastric Cancer and Progressive Grades of Premalignant Lesions
Conclusions: Our results suggest that humoral immune response against TAAs is generated already during premalignant stages. Impact: Based on the obtained results, cancer-associated autoantibodies might make a valuable contribution to the stratification of high-risk patients with premalignant lesions in the stomach through enhancing the positive predictive power of existing risk models. Cancer Epidemiol Biomarkers Prev; 26(10); 1564–74. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Meistere, I., Werner, S., Zayakin, P., Silina, K., Rulle, U., Pismennaja, A., Santare, D., Kikuste, I., Isajevs, S., Leja, M., Kupcinskas, L., Kupcinskas, J., Jonaitis, L., Wu, C.-Y., Brenner, H., Line, A., Kalnina, Z. Tags: Research Articles Source Type: research

Mediating Effect of Postsurgical Chemotherapy on Presence of Dementia and Survival among Patients 65 and Older with Stage III Colon Cancer
Conclusions: Preexisting dementia is significantly associated with worse survival for stage III colon cancer patients, and its deleterious effect is partially explained by decreased likelihood of postoperative chemotherapy receipt. Impact: This is the first study that provides estimate of the mediating effect of diminished chemotherapy in patients with stage III colon cancer and dementia, simultaneously demonstrating the cancer-specific survival benefit of chemotherapy in the presence of dementia. Cancer Epidemiol Biomarkers Prev; 26(10); 1558–63. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Chen, Y., Cress, R. D., Stewart, S. L., Semrad, T. J., Harvey, D., Tencredi, D. J., Beckett, L. Tags: Research Articles Source Type: research

A Prospective Study of Chronic Inflammation in Benign Prostate Tissue and Risk of Prostate Cancer: Linked PCPT and SELECT Cohorts
Conclusions: Benign tissue inflammation was positively associated with prostate cancer. Impact: This first prospective study of men without biopsy indication supports the hypothesis that inflammation influences prostate cancer development. Cancer Epidemiol Biomarkers Prev; 26(10); 1549–57. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Platz, E. A., Kulac, I., Barber, J. R., Drake, C. G., Joshu, C. E., Nelson, W. G., Lucia, M. S., Klein, E. A., Lippman, S. M., Parnes, H. L., Thompson, I. M., Goodman, P. J., Tangen, C. M., De Marzo, A. M. Tags: Research Articles Source Type: research

Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews
Conclusions: The 16 pancreatic cancer susceptibility loci similarly impact Jewish and non-Jewish white European subjects, both individually and as summary odds. Impact: These 16 pancreatic cancer susceptibility loci likely do not explain the higher risk seen in Ashkenazi Jews. Cancer Epidemiol Biomarkers Prev; 26(10); 1540–8. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Streicher, S. A., Klein, A. P., Olson, S. H., Amundadottir, L. T., DeWan, A. T., Zhao, H., Risch, H. A. Tags: Research Articles Source Type: research

Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations
Conclusions: Gene and network analysis uncovered loci associated with ALL that are missed by GWA studies, such as MEIS1. Furthermore, ALL-associated loci do not appear to interact directly with each other to influence ALL risk, and instead appear to influence leukemogenesis through multiple, complex pathways. Impact: We present a new pipeline for post hoc analysis of association studies that yields new insight into the etiology of ALL and can be applied in future studies to shed light on the genomic underpinnings of cancer. Cancer Epidemiol Biomarkers Prev; 26(10); 1531–9. ©2017 AACR. (Source: Cancer Epidemiolog...
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Nakka, P., Archer, N. P., Xu, H., Lupo, P. J., Raphael, B. J., Yang, J. J., Ramachandran, S. Tags: Research Articles Source Type: research

Tobacco Product Use Patterns, and Nicotine and Tobacco-Specific Nitrosamine Exposure: NHANES 1999-2012
Conclusions: Product consumption, and nicotine and TSNAs exposure of dual- and poly-tobacco product category users somewhat differ from those of single-product category users as defined by the T-TUPs model. Impact: Higher levels of cotinine and NNAL among dual- and poly-tobacco T-TUPs users compared with the single-product T-TUPs users may indicate health concerns. Cancer Epidemiol Biomarkers Prev; 26(10); 1525–30. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Choi, K., Sabado, M., El-Toukhy, S., Vogtmann, E., Freedman, N. D., Hatsukami, D. Tags: Research Articles Source Type: research

Serum Insulin, Glucose, Indices of Insulin Resistance, and Risk of Lung Cancer
Conclusions: Higher fasting serum insulin concentrations, as well as the presence of insulin resistance, appear to be associated with an elevated risk of lung cancer development. Impact: Although insulin is hypothesized to increase risk of some cancers, insulin and lung cancer remain understudied. Higher insulin levels and insulin resistance were associated with increased lung cancer risk. Although smoking cessation is the best method of lung cancer prevention, other lifestyle changes that affect insulin concentrations and sensitivity may reduce lung cancer risk. Cancer Epidemiol Biomarkers Prev; 26(10); 1519–24. &co...
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Argirion, I., Weinstein, S. J., Männistö, S., Albanes, D., Mondul, A. M. Tags: Research Articles Source Type: research

Recent Trends in Ovarian Cancer Incidence and Relative Survival in the United States by Race/Ethnicity and Histologic Subtypes
Conclusions: Over the last decade, incidence rates of epithelial ovarian cancer in the United States have decreased or remained stable across race/ethnic and histologic subgroups, except for clear cell carcinoma. Survival remains poorest among NHB women. Impact: Comparative histologic subtype distribution and incidence trends do not explain the ovarian cancer survival disparity disproportionately affecting NHB women. Cancer Epidemiol Biomarkers Prev; 26(10); 1511–8. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Park, H. K., Ruterbusch, J. J., Cote, M. L. Tags: Research Articles Source Type: research

The Cost-Effectiveness of Visual Triage of Human Papillomavirus-Positive Women in Three Low- and Middle-Income Countries
Conclusions: VIA triage of HPV-positive women is not likely to be cost-effective in settings with high cervical cancer burden. HPV alone followed by treatment may achieve greater health benefits and value for public health dollars. Impact: This study provides early evidence on the cost-effectiveness of HPV testing followed by VIA triage versus an HPV screen-and-treat strategy. Cancer Epidemiol Biomarkers Prev; 26(10); 1500–10. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Campos, N. G., Jeronimo, J., Tsu, V., Castle, P. E., Mvundura, M., Kim, J. J. Tags: Research Articles Source Type: research

Cervical Cancer Screening among Women from Muslim-Majority Countries in Ontario, Canada
Conclusions: We have shown that being born in a Muslim-majority country is associated with a decreased likelihood of being up-to-date on cervical screening in Ontario and that access to primary care has a sizeable impact on screening uptake. Impact: Screening efforts need to take into account the background characteristics of population subgroups and to focus on increasing primary care access for all. Cancer Epidemiol Biomarkers Prev; 26(10); 1493–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Lofters, A. K., Vahabi, M., Kim, E., Ellison, L., Graves, E., Glazier, R. H. Tags: Research Articles Source Type: research

The Association of Mammographic Density and Molecular Breast Cancer Subtype
Conclusions: Increased MD is more strongly associated with H2P tumors when compared with LA. Impact: Delineating risk factors specific to breast cancer subtype may promote development of individualized risk prediction models and screening strategies. Cancer Epidemiol Biomarkers Prev; 26(10); 1487–92. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Edwards, B. L., Atkins, K. A., Stukenborg, G. J., Novicoff, W. M., Larson, K. N., Cohn, W. F., Harvey, J. A., Schroen, A. T. Tags: Research Articles Source Type: research

Associations of Coffee Drinking and Cancer Mortality in the Cancer Prevention Study-II
Conclusions: These findings are consistent with many other studies that suggest coffee drinking is associated with a lower risk of colorectal, liver, female breast, and head and neck cancer. The association of coffee consumption with higher risk of esophageal cancer among nonsmokers in our study should be confirmed. Impact: These results underscore the importance of assessing associations between coffee consumption and cancer mortality by smoking status. Cancer Epidemiol Biomarkers Prev; 26(10); 1477–86. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Gapstur, S. M., Anderson, R. L., Campbell, P. T., Jacobs, E. J., Hartman, T. J., Hildebrand, J. S., Wang, Y., McCullough, M. L. Tags: Research Articles Source Type: research

Highlights of This Issue
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Tags: Highlights Source Type: research

Gestational Diabetes Mellitus and Incident Invasive Breast Cancer--Letter
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Mormile, R. Tags: Letter to the Editor Source Type: research