Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes
Abstract The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by gavage, beginning 15 days before the surgical procedure and lasting until the day the animals were euthanized. A CSD (5 mm Ø) was made in the calvaria of each animal, which was allocated to one of 3 subgroups, according to the biomaterial ...
Source: Brazilian Oral Research - February 7, 2020 Category: Dentistry Source Type: research
Smad1/5 signal transduction regulates the ameloblastic differentiation of induced pluripotent stem cells
Abstract Induced pluripotent stem (iPS) cells could be induced into ameloblast-like cells by ameloblasts serum-free conditioned medium (ASF-CM), and bone morphogenetic proteins (BMPs) might be essential during the regulation of this process. The present study investigates the signal transduction that regulates the ameloblastic differentiation of iPS cells induced by ASF-CM. Mouse iPS cells were characterized and then cultured for 14 days in epithelial cell medium (control) or ASF-CM. Bone morphogenetic protein receptor II (BMPR-II) siRNA, inhibitor of Smad1/5 phosphorylation activated by activin receptor-like kinase (ALK) ...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research
The effect of ionizing radiation on properties of fluoride-releasing restorative materials
Abstract The purpose of this study was to evaluate the effect of ionizing radiation from high energy X-ray on fluoride release, surface roughness, flexural strength, and surface chemical composition of the materials. The study groups comprised five different restorative materials: Beautifil II, GCP Glass Fill, Amalgomer CR, Zirconomer, and Fuji IX GP. Twenty disk-shaped specimens (8x2 mm) for fluoride release and 20 bar-shaped specimens (25 x 2x 2 mm) for flexural strength were prepared from each material. Each material group was divided into two subgroups: irradiated (IR) and non-irradiated (Non-IR). The specimens from IR...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research
Microstructural and mechanical analysis of two CAD-CAM lithium disilicate glass-reinforced ceramics
Abstract The aim of this study was to analyze the structural, morphological and mechanical properties of two different lithium disilicate glass-reinforced ceramics for CAD-CAM systems (IPS e.max CAD and Rosetta SM). Five methodologies were used for both ceramics: microstructure (n = 2) was analyzed using x-ray diffraction (XRD); morphological properties (n = 2) were analyzed by scanning electron microscopy (SEM), with and without hydrofluoric etching; porosity (n = 3) was assessed using 3D micro-computed tomography (micro-CT); flexural strength was measured (n =1 0) using the three-point bending test; and bond strength was...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research
Esthetic perception of facial profile changes after extraction and nonextraction Class II treatment
Abstract This retrospective study evaluated facial profile pleasantness determined by two protocols of Class II treatment. The sample comprised facial profile silhouettes obtained retrospectively from the pretreatment (T1) and posttreatment (T2) cephalograms of 60 patients (42 males and 18 females) divided into two groups. One group of 30 patients (mean age of 12.84 years) was treated with the extraction of maxillary first premolars (mean treatment time of 2.7 years), and the other group of 30 patients (mean age of 12.81 years) was treated with a mandibular advancement appliance (Forsus) (mean treatment time of 2.49 years)...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research
Adhesive resistance of a copaiba oil-based dentin biomodifier
This study analyzed the effect of prior application of copaiba oil (CO) emulsions as a dentin cleaning substance on microleakage and microtensile adhesive strength. Twenty-five premolars and sixty-four molars were used for microleakage and microtensile assays. For the microleakage assays, specimens with standard class V cavities were divided (n = 5), according to the tested CO emulsions: CO10%X, CO10%Y, and CO10%Z, as well as chlorhexidine 2% (CHX) and distilled water (DW), as positive and negative controls, respectively. Restorations were performed using the Adper Single Bond ® and/or Clearfil SE Bond® systems. Cervical...
Source: Brazilian Oral Research - January 31, 2020 Category: Dentistry Source Type: research
Does the implant-abutment interface interfere on marginal bone loss? A systematic review and meta-analysis
The objective of this systematic review was to compare the conical internal connection (IC) with the external hexagonal connection (EH) on the occurrence of marginal bone loss ( Δ MBL). Different databases were used to carry out the selection of the elected studies. The studies were judged according to the risk of bias as “ high ” , “ low ” and “ unclear ” risk. For the meta-analysis we included only studies that could extract the data of Δ MBL, survival rate (SR) and probing depth (PD). No statistically significant differences were found for Δ MBL data at one, three- and five-year survival rates between i...
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
The impact of maintenance on peri-implant health
Abstract Most of the literature evaluating dental implants focuses on implant survival, which is a limited proxy for the successful rehabilitation of patients with missing teeth. Success should include not only survival but also lack of mechanical, biological, and esthetics problems. A comprehensive review of local and systemic risk factors prior to implant placement will allow the tailoring of treatment planning and maintenance protocols to the patient ’ s profile in order to achieve longitudinal success of the therapy. This review discusses the role of controlling different risk factors and prevention/treatment of peri...
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
Treatment of peri-implant soft tissue defects: a narrative review
Abstract Soft tissue defects around dental implants, such as papilla or volume loss, peri-implant recession and alterations of the ridge color and/or texture, lead to esthetic and functional complaints. Treatments of these defects in implants are more demanding than in teeth because peri-implant tissue exhibits different anatomical and histological characteristics. This narrative review discusses the proposed treatments for soft tissue defects around implants in the current literature. Several clinical and pre-clinical studies addressed methods to augment the quantity of the peri-implant keratinized mucosa. Autogenous graf...
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
New strategies and developments for peri-implant disease
We present novel treatment for infection control and biological rationale of additional use of guided bone regeneration, with an illustrative explanation of the treatments presented with two cases. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
Implant-based factor as possible risk for peri-implantitis
In conclusion, further evidences are required to a better understanding of the influence of implant-based factors in the occurrence of peri-implantitis. Large population-based studies including concomitant analyses of implant- and patient-based factors are required to provide strong evidence of a possible association with peri-implantitis in a higher probability. The identification of these factors is essential for the establishment of strategies to prevent peri-implantitis. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
Host response and peri-implantitis
Abstract Considering the absence of predictable and effective therapeutic interventions for the treatment of peri-implantitis, scientific evidence concerning the host response profile around dental implants could be important for providing in the future a wider preventive and/or therapeutic window for this peri-implant lesion, indicating biomarkers that provide quantifiable measure of response to peri-implant therapy. Moreover, a better knowledge of pattern of host osteo-immunoinflammatory modulation in the presence of peri-implantitis could either benefit the early diagnostic of the disease or to cooperate to prognostic i...
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
An umbrella review on the effects of diabetes on implant failure and peri-implant diseases
Abstract The aim of this review is to summarize the evidence on associations between diabetes mellitus (DM) and complications around dental implants. Electronic database searches of MEDLINE, EMBASE, JBI Database of Systematic Reviews and Implementation Reports, Cochrane Database of Systematic Reviews and the PROSPERO register were performed from 1990 up to and including May 2018, using MeSH terms and other keywords. Systematic reviews and meta-analyses investigating the associations of DM and implant complications (failure, survival, bone loss, peri-implant diseases, and post-surgery infection) were eligible. The quality o...
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
Does traumatic occlusal forces lead to peri-implant bone loss? A systematic review
Abstract Observational studies have indicated that crestal bone level changes at implants are typically associated with clinical signs of inflammation, but still mechanical overload has been described as possible factor leading to hard – tissue deficiencies at implant sites without mucosal inflammation. The aim of this paper was systematically review the literature regarding the possible effect of traumatic occlusal forces on the peri-implant bone levels. Literature search was conducted using PubMed, Scielo and Lilacs, including the following terms: oral OR dental AND implant$ AND (load OR overload OR excessive load OR f...
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
Prevalence of peri-implant diseases – a critical review on the current evidence
In conclusion, it can be stated that a wide range for reporting the prevalence of peri-implantitis can be found and no real estimation of the global burden of the disease can be made. Applying accurate case definitions for peri-implantitis is the most important factor for reporting the prevalence and should be strictly followed in future reports. (Source: Brazilian Oral Research)
Source: Brazilian Oral Research - September 30, 2019 Category: Dentistry Source Type: research
