Protein astrogliopathies in human neurodegenerative diseases and aging
Abstract
Neurodegenerative diseases are characterized by progressive dysfunction and loss of neurons associated with depositions of pathologically altered proteins showing hierarchical involvement of brain regions. The role of astrocytes in the pathogenesis of neurodegenerative diseases is explored as contributors to neuronal degeneration or neuroprotection pathways, and also as potential mediators of the transcellular spreading of disease‐associated proteins. Protein astrogliopathy (PAG), including deposition of amyloid‐β, prion protein, tau, α‐synuclein, and very rarely transactive response DNA‐binding protein ...
Source: Brain Pathology - August 13, 2017 Category: Neurology Authors: Gabor G. Kovacs, Virginia M. Lee, John Q. Trojanowski Tags: MINI ‐SYMPOSIUM: ASTROGLIA IN NEURODEGENERATIVE DISEASES Source Type: research
Diversity of astroglial responses across human neurodegenerative disorders and brain aging
Abstract
Astrogliopathy refers to alterations of astrocytes occurring in diseases of the nervous system, and it implies the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system. Reactive astrocytosis refers to the response of astrocytes to different insults to the nervous system, whereas astrocytopathy indicates hypertrophy, atrophy/degeneration and loss of function and pathological remodeling occurring as a primary cause of a disease or as a factor contributing to the development and progression of a particular disease. Reactive astrocytosis sec...
Source: Brain Pathology - August 13, 2017 Category: Neurology Authors: Isidro Ferrer Tags: MINI ‐SYMPOSIUM: ASTROGLIA IN NEURODEGENERATIVE DISEASES Source Type: research
Stratification of astrocytes in healthy and diseased brain
Abstract
Astrocytes, a subtype of glial cells, come in variety of forms and functions. However, overarching role of these cell is in the homeostasis of the brain, be that regulation of ions, neurotransmitters, metabolism or neuronal synaptic networks. Loss of homeostasis represents the underlying cause of all brain disorders. Thus, astrocytes are likely involved in most if not all of the brain pathologies. We tabulate astroglial homeostatic functions along with pathological condition that arise from dysfunction of these glial cells. Classification of astrocytes is presented with the emphasis on evolutionary trails, morphol...
Source: Brain Pathology - August 13, 2017 Category: Neurology Authors: Alexei Verkhratsky, Robert Zorec, Vladimir Parpura Tags: MINI ‐SYMPOSIUM: ASTROGLIA IN NEURODEGENERATIVE DISEASES Source Type: research
Introduction
(Source: Brain Pathology)
Source: Brain Pathology - August 13, 2017 Category: Neurology Authors: Gabor G. Kovacs Tags: MINI ‐SYMPOSIUM: ASTROGLIA IN NEURODEGENERATIVE DISEASES Source Type: research
Issue Information
(Source: Brain Pathology)
Source: Brain Pathology - August 13, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - July 30, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - July 30, 2017 Category: Neurology Source Type: research
Alterations in the steroid biosynthetic pathways in the human prefrontal cortex in mood disorders: a postmortem study
In conclusion, this study suggests the presence of a disturbance in the endogenous synthesis of DHEA and DHEAS in mood disorders, which has a close relationship with BDNF‐TrkB signaling. This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - July 1, 2017 Category: Neurology Authors: Xin ‐Rui Qi, Sabina Luchetti, Ronald W.H. Verwer, Arja A. Sluiter, Matthew R.J. Mason, Jiang‐Ning Zhou, Dick F. Swaab Tags: Original Article Source Type: research
Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis
Conclusion: Tissue microarray methodology and quantitative analysis provides evidence of complement dysregulation in MS GML, including an association of the numerical density of C1q+ cells with tissue lesions. Our work confirms that complement activation and dysregulation occur in all cases of progressive MS and suggest that complement may provide potential biomarkers of the disease. This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - July 1, 2017 Category: Neurology Authors: Sam Loveless, James W. Neal, Owain W. Howell, Katharine E. Harding, Patrick Sarkies, Rhian Evans, Ryan J. Bevan, Svetlana Hakobyan, Claire L. Harris, Neil P. Robertson, B. Paul Morgan Tags: Research Article Source Type: research
Autophagy in Neurodegenerative Diseases: Pathogenesis and Therapy
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - July 1, 2017 Category: Neurology Authors: Fang Guo, Xinyao Liu, Huaibin Cai, Weidong Le Tags: Review Source Type: research
Rapid amyloid ‐β oligomer and protofibril accumulation in traumatic brain injury
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - June 19, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - June 19, 2017 Category: Neurology Source Type: research
TGF β pathway deregulation and abnormal phospho‐SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis‐Dutch type
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - June 12, 2017 Category: Neurology Source Type: research
Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - June 12, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - June 12, 2017 Category: Neurology Source Type: research
