Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis

Conclusion: Tissue microarray methodology and quantitative analysis provides evidence of complement dysregulation in MS GML, including an association of the numerical density of C1q+ cells with tissue lesions. Our work confirms that complement activation and dysregulation occur in all cases of progressive MS and suggest that complement may provide potential biomarkers of the disease. This article is protected by copyright. All rights reserved.

Source: Brain Pathology - July 1, 2017 Category: Neurology Authors: Sam Loveless, James W. Neal, Owain W. Howell, Katharine E. Harding, Patrick Sarkies, Rhian Evans, Ryan J. Bevan, Svetlana Hakobyan, Claire L. Harris, Neil P. Robertson, B. Paul Morgan Tags: Research Article Source Type: research