CNS high ‐grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue
In conclusion, we think CNS HGNET‐BCOR are a certain type of neuroepithelial tumor relatively close to glioma, not CCSK or URCS/PMMTI occurring in the CNS. This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 1, 2017 Category: Neurology Authors: Yuka Yoshida, Sumihito Nobusawa, Satoshi Nakata, Mitsutoshi Nakada, Yoshiki Arakawa, Yohei Mineharu, Yasuo Sugita, Takako Yoshioka, Asuka Araki, Yuichiro Sato, Hideo Takeshima, Masahiko Okada, Akira Nishi, Tatsuya Yamazaki, Kenichi Kohashi, Yoshinao Oda, Tags: Research Article Source Type: research
RELN signaling modulates glioblastoma growth and substrate ‐dependent migration
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 1, 2017 Category: Neurology Authors: Markus Schulze, Christ Violonchi, Stefan Swoboda, Tobias Welz, Eugen Kerkhoff, Sabine Hoja, Susanne Br üggemann, Johann Simbürger, Jörg Reinders, Markus J. Riemenschneider Tags: Research Article Source Type: research
BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: A histological and molecular analysis focusing on intratumoral heterogeneity
In conclusion, E‐GBM frequently exhibit BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions, and these alterations tend to coexist in E‐GBM. Taken together with the facts that only one PXA preceded E‐GBM among these lower‐grade lesions, and that co‐occurrence of BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions have been reported to be rare in conventional lower‐grade diffuse gliomas, the diffuse glioma‐like components may be distinct infiltrative components of E‐GBM, reflecting intratumoral heterogeneity. This article is protected by copyright. All rights reserved. (So...
Source: Brain Pathology - November 1, 2017 Category: Neurology Authors: Nozomi Nakajima, Sumihito Nobusawa, Satoshi Nakata, Mitsutoshi Nakada, Tatsuya Yamazaki, Nozomi Matsumura, Kenichi Harada, Hadzki Matsuda, Nobuaki Funata, Shoichi Nagai, Hideo Nakamura, Atsushi Sasaki, Jiro Akimoto, Junko Hirato, Hideaki Yokoo Tags: Research Article Source Type: research
TREM2 expression in the human brain: a marker of monocyte recruitment?
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2017 Category: Neurology Source Type: research
Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2017 Category: Neurology Source Type: research
Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - October 27, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - October 27, 2017 Category: Neurology Source Type: research
Corrigendum
(Source: Brain Pathology)
Source: Brain Pathology - October 27, 2017 Category: Neurology Tags: CORRIGENDUM Source Type: research
Society news
(Source: Brain Pathology)
Source: Brain Pathology - October 27, 2017 Category: Neurology Tags: SOCIETY NEWS Source Type: research
Issue Information
(Source: Brain Pathology)
Source: Brain Pathology - October 27, 2017 Category: Neurology Tags: ISSUE INFORMATION Source Type: research
Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - October 24, 2017 Category: Neurology Source Type: research
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Brain Pathology, Ahead of Print. (Source: Brain Pathology)
Source: Brain Pathology - October 24, 2017 Category: Neurology Source Type: research
Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke
Abstract
The Rho GTPase Rac1 is a multifunctional protein involved in distinct pathways ranging from development to pathology. The aim of the present study was to unravel the contribution of neuronal Rac1 in regulating the response to brain injury induced by permanent focal cerebral ischemia (pMCAO). Our results show that pMCAO significantly increased total Rac1 levels in wild type mice, mainly through rising nuclear Rac1, while a reduction in Rac1 activation was observed. Such changes preceded cell death induced by excitotoxic stress. Pharmacological inhibition of Rac1 in primary neuronal cortical cells prevented the incr...
Source: Brain Pathology - October 24, 2017 Category: Neurology Authors: Cansu Karabiyik, Rui Fernandes, Francisco Ros ário Figueiredo, Renato Socodato, Cord Brakebusch, Kate Lykke Lambertsen, João Bettencourt Relvas, Sofia Duque Santos Tags: Research Article Source Type: research
