Stimulation and repression of cancer development by caveolae and nitric oxide
Cedric M Blouin, David M OjciusBiomedical Journal 2015 38(5):365-366 (Source: Biomedical Journal)
Source: Biomedical Journal - October 9, 2015 Category: Biomedical Science Authors: Cedric M BlouinDavid M Ojcius Source Type: research
Positive perspectives from proton therapy
Emma Louise WaltonBiomedical Journal 2015 38(5):361-364In this issue of the Biomedical Journal, we take a look at some of the benefits of proton therapy, which is an emerging technique in cancer treatment and highlight an animal study, showing that a common fruit ripening agent is toxic when used in excessive doses. Finally, this issue includes reports that shed light on the genetics of stroke and childhood leukemia. (Source: Biomedical Journal)
Source: Biomedical Journal - October 9, 2015 Category: Biomedical Science Authors: Emma Louise Walton Source Type: research
Validation of Indian diabetic risk score in diagnosing type 2 diabetes mellitus against high fasting blood sugar levels among adult population of central India
Ajeet Singh Bhadoria, Pradeep Kumar Kasar, Neelam Anupama ToppoBiomedical Journal 2015 38(4):359-360Globally the increasing prevalence of diabetes mellitus (DM) is major public health concern. The Indian Diabetes Risk Score (IDRS) was developed by Madras Diabetes Research Foundation (MDRF) as a simple tool to help detect undiagnosed type 2 DM (T2DM) in the community. We conducted a study among 911 adults of Jabalpur District to validate the IDRS score against increased fasting blood sugar levels in diagnosing T2DM. T2DM was confirmed either by history of previously known disease or fasting plasma glucose ≥126 ...
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Ajeet Singh BhadoriaPradeep Kumar KasarNeelam Anupama Toppo Source Type: research
Awareness and practice patterns of family planning methods among antenatal women in Indian community: Are we hitting the bull's eye?
Deepti Choudhary, Reena Pal, Neerja GoelBiomedical Journal 2015 38(4):356-358A questionnaire-based cross-sectional survey was undertaken to assess the awareness and practice patterns of family planning among the antenatal women in North India. The study included 400 respondents. Three-fourths of the respondents (74.2%, n = 297) were aware of family planning methods. Condoms were the most commonly used family planning method (78.2%), while intrauterine devices and oral contraceptive pills were used by 25.5% and 16.7% respondents, respectively. The main reasons cited for not using contraception we...
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Deepti ChoudharyReena PalNeerja Goel Source Type: research
Variability of distal femoral valgus resection angle in patients with end-stage osteoarthritis and genu varum deformity: Radiographic study in an ethnic Asian population
Conclusions: 32% of Asian patients present with a distal femoral valgus resection angle that is outside the range of 5° ±2°. Taking a long-leg weight-bearing split scanogram may provide information that allows the surgeon to determine the true distal femoral valgus resection angle and adjust the cut accordingly.
Level of Evidence: Therapeutic level III. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Chien-Yin LeeTsan-Wen HuangKuo-Ti PengMel S LeeRobert Wen-Wei HsuWun-Jer Shen Source Type: research
Real-time photothermal imaging and response in pulsed dye laser treatment for port wine stain patients
Conclusion: Using infrared thermal imaging instrument and thermal wave equation, we can predict the skin temperature distribution in FLPPDL for PWS patients during the treatment. In conjunction with CSC, the complications can be minimized. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Cheng-Jen ChangDe-Yi YuShu-Ying ChangYen-Chang HsiaoKuen TingKuen-Tsann ChenKuang-Hua Hou Source Type: research
Effects of proximal grooves and abutment height on the resistance of resin-cemented crowns in teeth with inadequate resistance: An in vitro study
Conclusion: An abutment height of 3 mm provided adequate resistance for single cast crowns when self-adhesive modified-resin cement was used. Preparing a pair of proximal grooves on abutments shorter than 4 mm had no significant influence on the resistance. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Yi-Chen HuangChun-Li LinEllen Wen-Ching Ko Source Type: research
Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer
Conclusions: Metastatic lymph node ratio greater than 0.4 and non-anatomic resection were poor prognostic factors for disease-free survival. Anatomic resection for selected N2 patients may play a crucial role in the overall survival rate. Perineural invasion showed an adverse impact on disease-free survival, but further investigation is warranted. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Chen-Ping HsiehJui-Ying FuYun-Hen LiuCheng-Ta YangMing-Ju HsiehYing-Huang TsaiYi-Cheng WuChing-Yang Wu Source Type: research
A morphological and morphometric study of proximal and distal ends of dry radii with its clinical implications
Conclusion: This study will be useful for orthopedic surgeons in making prosthesis for the proximal and distal ends of radius. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Chandni GuptaSneha Guruprasad KalthurJC MalsawmzualiAntony Sylvan D'souza Source Type: research
Inferior hypogastric plexus blockade versus acupuncture for the management of idiopathic chronic pelvic pain: A randomized clinical trial
Conclusion: The study results showed that inferior hypogastric blockade had a 72.6% success rate and showed a significantly higher effect on reducing pain intensity in a short period of time in the management of CPP, compared to acupuncture. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Magdy M AminAbdou S Ait-AllahAhmed El-Said A AliRafat A SalemSalah Roshdy AhmedMohamed Akhatim Alsammani Source Type: research
Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study
Conclusion: Thyroid disorders are common in non-pregnant females in the Western province of Saudi Arabia, and they are associated with an increase in the prevalence of both anemia and iron deficiency. Further studies are needed to determine the underlying mechanism (s) contributing to the development of thyroiditis-induced anemia in the kingdom and the role of thyroid hormones in iron metabolism. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Bassem Refaat Source Type: research
In vitro anti-inflammatory activity of fractionated Euphorbia hirta aqueous extract on rabbit synovial fibroblasts
Conclusions: Fraction A of the aqueous extract inhibited the production of PGE 2 from activated HIG-82 cells to a greater extent than the crude aqueous extract. Bioactive compounds with anti-inflammatory activity are likely to be concentrated in Fraction A of E. hirta aqueous extract. (Source: Biomedical Journal)
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Jocelyn ChenHui Meng ErShar Mariam MohamedYu Sui Chen Source Type: research
The emerging theme of redox bioenergetics in health and disease
Philip A Kramer, Victor M Darley-UsmarBiomedical Journal 2015 38(4):294-300Mitochondrial function has long been recognized as central to normal physiology and a contributor to a broad range of pathologies. Much of the early research in mitochondrial biology focused on the mechanisms to generate ATP and characterization of mitochondria from highly energetic tissues such as the heart or liver. More recent studies emphasize the role of mitochondria in redox signaling and in less energetic cells such as those in the innate immune system and the vasculature. In this short overview, we discuss some of these recent developments i...
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Philip A KramerVictor M Darley-Usmar Source Type: research
Studying host-microbiota mutualism in Drosophila: Harnessing the power of gnotobiotic flies
Dali Ma, Gilles Storelli, Mélanie Mitchell, François LeulierBiomedical Journal 2015 38(4):285-293The complex interaction between the metazoan host and its commensal gut microbiota is one of the essential features of symbiosis in the animal kingdom. As there is a burgeoning interest to decipher the molecular dialog that shapes host-microbiota mutualism, the use of gnotobiotic model organism becomes an imperative approach to unambiguously parse the specific contributions to such interaction from the microbiome. In this review, we focus on several remarkable gnotobiotic studies in Drosophila that funct...
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Dali MaGilles StorelliMélanie MitchellFrançois Leulier Source Type: research
The multilayered innate immune defense of the gut
Laure El Chamy, Nicolas Matt, Monde Ntwasa, Jean-Marc ReichhartBiomedical Journal 2015 38(4):276-284In the wild, the fruit fly Drosophila melanogaster thrives on rotten fruit. The digestive tract maintains a powerful gut immune barrier to regulate the ingested microbiota, including entomopathogenic bacteria. This gut immune barrier includes a chitinous peritrophic matrix that isolates the gut contents from the epithelial cells. In addition, the epithelial cells are tightly sealed by septate junctions and can mount an inducible immune response. This local response can be activated by invasive bacteria, or triggered by comme...
Source: Biomedical Journal - August 10, 2015 Category: Biomedical Science Authors: Laure El ChamyNicolas MattMonde NtwasaJean-Marc Reichhart Source Type: research
