Bangladesh Medical Research Council Bulletin This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gentamicin in Newborn Sepsis: Once Daily Dose versus Twice Daily Dose
Gentamicin is commonly used as first line drug in neonatal sepsis. It is usually used in combination with other drugs. It is a nephrotoxic and an ototoxic drug. Long term use causes renal failure and hearing impairment. Its efficacy depends on the peak concentration, and its toxicity is related to the trough concentration. There is no set protocol of using gentamicin in neonate in Bangladesh, whether it should be used once daily or twice, it is till debatable in this perspective. In daily practice, it is not followed up trough and peak concentration of gentamicin, so it is not known the renal and hearing status of the baby...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Birth Prevalence of Congenital Cytomegalovirus (CMV) infection in a cohort of pregnant women in Bangladesh
Cytomegalovirus (CMV) is a frequent cause of congenital infection in humans in all regions of the world. In contrast to most congenital viral infections, congenital CMV infection and disease have been consistently demonstrated in populations with a high seroprevalence. Three hundred pregnant women were studied prospectively in their 1st, 2nd and 3rd trimester to determine the seroprevalence and seroconversion of CMV in pregnancy. After birth, babies were also tested for anti CMV IgM to determine the rate of birth prevalence. Anti CMV IgG and IgM tests were performed by chemiluminescence methods. All 300 (100%) pregnant wom...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Clinical and Radiographic Efficacy of Portland Cement as Pulpotomy Material in Human Primary Molar
Mineral trioxide aggregates (MTA) has been considered one of the most effective pulpotomy materials as it induces the formation of dentine at a greater rate with superior structural integrity, minimal inflammation and nominal hyperplasia. Portland cement (PC), posing the principal chemical elements with similar mechanisms of action, physical properties and biocompatibility like MTA, may be considered as effective alternative for the same. So, the objective of the study was to compare the clinical and radiographic outcome of Portland cement and mineral trioxide aggregates as pulpotomy material in primary teeth. A total of 4...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Prevalence of anti-HBc total positivity in an impoverished Urban Community in Banglades
The infection with the Hepatitis B virus (HBV) is a global health problem. Hepatitis B virus (HBV) infections are rapidly spreading in developing countries due to the lack of health education, poverty, illiteracy and Hepatitis B vaccination. No widespread population based data of HBV is available in the country ' s aspect. So, a population-based serological survey was done to determine the prevalence of the Hepatitis B core antibody total (IgM+IgG) in an impoverished Urban Community in Dhaka, Bangladesh. A descriptive cross-sectional study was conducted among 384 healthy individuals and age between 18-60 years from the urb...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Splenic Volume: Correlation between Ultrasonogram and Standard CT Measurements
Evaluation of splenic enlargement is important in the diagnosis and management of various diseases including liver disease, lymphoma and other primary or metastatic neoplasm. This cross sectional study was conducted in the department of radiology and imaging in Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) from July 2007 to June 2009. The main objective of the study was to find out a more accurate sonographic measurement of splenic volume that well correlate with gold standard computed tomography (CT) volume. A total of 228 subjects were included in the study. A...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Propranolol Versus corticosteroids for Infantile Hemangiomas: A Randomized Control Trial in a Tertiary care Hospital
Infantile hemangiomas are the most common vascular tumor of infancy and childhood. Sometimes these lesions interfere with normal function& produce serious disfigurement that is unlikely to resolve on its own and then treatment is required. While evidence most supports the use of corticosteroids, there is no well- studied or Federal Drug Administration (FDA) approved systemic therapy for haemangiomas of Infancy. Dramatic improvement of complicated haemangioma by propranolol has recently been reported, but to date, details for initiating therapy, monitoring and potential risks in relation to Corticosteroids were not comp...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Helicobacter pylori cagA gene Polymorphism in Patients with Gastroduodenal Diseases
Helicobacter pylori is a genetically diverse bacterial pathogen and itsCagA gene is a major virulence factor that plays an important role in gastroduodenal pathologies. The biological function of cagA depends on tyrosine phosphorylation within the EPIYA (Glutamate-Proline-Isoleucine-Tyrosine-Alanine) motifs at the C-terminal region of the protein. This region may undergo polymorphism to give different types of EPIYA motifs. EPIYA motif diversity may provide a useful tool for prediction ofH. pylori pathogenic activity and accurate determination of number and type of cagA EPIYA motifs could identify the virulentH. pylori. Th...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Incretin Hormones and Insulin Responses During OGTT in Newly Diagnosed T2DM Patients
Several research groups have reported variable results about incretin effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1) particularly, as well as cytokines balance in type 2 diabetes mellitus (T2DM). The present case-control prospective interventional study was conducted in 2014-2015 at Medical College for Women& Hospital, Dhaka, investigating responses of incretin hormones and insulin to oral glucose tolerance test (OGTT) in Bangladeshi subjects. Blood samples were collected from 36 OGTT positive adult T2DM patients (Pt) and 30 normal adults (NC) at ' 0 ' minute (fasting) ...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Risk Factors for Cardiovascular Diseases Among Urban Schoolchildren from Affluent Families
Smoking, physical inactivity, obesity, raised blood pressure, low dietary intake of vegetables and fruits have been identified as risk factors for cardiovascular diseases. The study was aimed to find out the extent of risk factors for cardiovascular diseases among adolescent schoolchildren from affluent families of Dhaka city. This cross sectional study was done among 386 students of two English medium high schools during July 2006 to June 2007. Sixty one percent of the sample was boys. The children were of 10-18 years age group (mean=13.5 years). Half of the parents had postgraduate education, fathers mostly businessmen a...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Per Rectal Bleeding in Children: Experiences in the Department of Paediatric Surgery in BSMMU
This study was carried out in an attempt to find out causes, presentation and the proper management that can be offered to the affected infants and children.This retrospective study was carried out from January 2012 to December 2014 in the department of Paediatric Surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All patients presenting with the complaint of per rectal bleeding were included.   But patients who needed emergency surgical intervention were excluded from this study. The data were reviewed for gender, age, causes of rectal bleeding and type, number, site, recurrence rate and t...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Core Competency of Mid-level Public Health Managers in Bangladesh
Bangladesh has been making remarkable progress in health sector. Despite, there are some areas where further intervention is required. People-centered health systems cannot be strengthened without competent management. Core competencies are the essential knowledge, skills and attitudes required for the practice of public health. This was a first kind of effort to assess the core competencies of mid-level public health managers, working at different tiers of health system in Bangladesh.   This descriptive cross-sectional study was conducted from July 2012 to June 2013, to assess the core competencies of mid-level public he...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Determination of HER-2/neu gene Status by Chromogenic in Situ Hybridisation Assay on Borderline (2+) Immunohistochemistry Cases in Patients with Invasive Breast Carcinoma: An Experimental Study on Preserved Tissue
HER-2 (also known as HER-2/neu) is a member of the epidermal growth factor (EGF) receptor family. The amplification of oncogene HER-2 is presented in 20 to 30% of breast cancers and results in an increase of the protein expression. HER-2 over expression has also been shown to correlate with poor prognosis. It is associated with poorly differentiated high grade tumors with lymph node involvement, greater risk of recurrence and relative resistance to some types of chemotherapy. The receptor is however a target for treatment with anti HER-2 antibody trastuzumab (Herceptin). Immunohistochemistry analysis for HER 2 scoring is s...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Hospital Based Gestational Age Specific Birth Charts in Urban Bangladesh
This study aimed to develop such growth chart in Bangladesh, to exactly evaluate an individual newborn ’s growth pattern by comparing growth of its different parts with that of a standard one. A cross sectional observational study conducted at fifteen non-government maternity centers located in different parts of Dhaka, Narayanganj and Narsingdi. Birth weight, birth length, head and chest circumfer ences of five thousand one hundred and five singleton newborns’ with gestational ages ranging from 35 to 42 weeks were recorded during June 2014 to July 2015. Trained Physicians and paramedics of respective centers recorded ...
Source: Bangladesh Medical Research Council Bulletin - December 14, 2017 Category: International Medicine & Public Health Source Type: research

Fanconi Anaemia – A Rare Case Report
Fanconi anaemia is a rare and most common form of inherited aplastic anaemia. It is mostly autosmal (except one x link) recessive disorder characterized by diverse congenital malformations, progressive pancytopenia, and predisposition to both haematological malignancy and solid tumours. Congenital malformation varies from patient to patient and may affect the skeletal system as well as organ systems. Highly variable phenotypic   presentation with clinical menifestations makes difficult for diagnosis in some cases. Chromosomal breakage study induce by Mitomycin-C (MMC)/Diepoxybutane(DEB) provide a unique cellular marker fo...
Source: Bangladesh Medical Research Council Bulletin - April 18, 2017 Category: International Medicine & Public Health Source Type: research

Fanconi Anaemia – A Rare Case Report
Fanconi anaemia is a rare and most common form of inherited aplastic anaemia. It is mostly autosmal (except one x link) recessive disorder characterized by diverse congenital malformations, progressive pancytopenia, and predisposition to both haematological malignancy and solid tumours. Congenital malformation varies from patient to patient and may affect the skeletal system as well as organ systems. Highly variable phenotypic   presentation with clinical menifestations makes difficult for diagnosis in some cases. Chromosomal breakage study induce by Mitomycin-C (MMC)/Diepoxybutane(DEB) provide a unique cellular marker fo...
Source: Bangladesh Medical Research Council Bulletin - April 18, 2017 Category: International Medicine & Public Health Source Type: research