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Stenting in Takayasu ’s Arteritis: A Case Report
Takayasu arteritis (TA),  also known as idiopathic medial aortopathy or pulseless disease, is a granulomatous large vessel vasculitis that predominantly affects the aorta and its major branches. It may also affect the pulmonary arteries. The exact cause is not well known but the pathology is thought to be similar to gi ant cell arteritis. There is segmental and patch granulomatous inflammation of the aorta which results in stenosis, thrombosis and aneurysm formation. Half of the patients present with an initial systemic illness whereas the other 50% present with late-phase complications. There is a strong female pre...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Mutation Pattern in Beta Thalassaemia Trait Population: A Basis for Prenatal Diagnosis
A total of 100 Bangladeshi beta thalassaemia carrier subjects were analysed by allele specific primers using Amplification Refractory Mutation System – Polymerase Chain Reaction.  Among these, four common mutations were found in 90 cases (90.0%), five less common mutations in 9 cases (9.0%) and a rare mutation in 1 case (1.0%). Among the four common mutations, IVS1-5 (G-C) was the most common beta thalassaemia mutation and found in 63.0% cases , followed by Cd 30 (G-C) in 18.0%, Fr 8/9 (+G) in 5.0% and Fr 41/42 (-TTCT) in 4.0% respectively. Among the five less common mutations, Cd16 (-C) was found in 3.0%, -90 (C-T) and...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Immune Response Among the Children to Hepatitis B Vaccination: A Community-based Study in Bangladesh
Hepatitis B virus infection is a vaccine preventable infection of liver which remains a key public health burden globally. The development of Anti-HBs titre greater than or equal to 10 IU/L is considered as protective immunity and any titre less than 10 IU/L as non-protective following HBV vaccination. There is no comprehensive and authentic data regarding the immune response even 10 years after the integration of the HBV vaccine in to the EPI programme in Bangladesh and specifically, in Brahmonbaria district. The study was also aimed to assess the long term immune response among HBV vaccinated children. Blood sample from ...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

An Evaluation of Correction of Idiopathic Kyphoscoliosis by Axial Translation Technique with Pedicle Screw and Rod
As sufficient study not available in this subcontinent about correction of idiopathic kyphoscoliosis by axial translation technique, a group of patients of Adolescent Idiopathic Scoliosis (AIS) was selected to evaluate the outcome of rod rotation technique. The curve correction with more screw on the concave site was assessed, patient satisfaction and correction of cobb angle. Post operative radiological and functional outcome were assessed. Twenty consecutive patients (8 males, 12 females) with an age range from 10 to 24 years. Post operatively all were followed-up for 18 months. All patients were under went pedicle screw...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Outcome of Concurrent Chemoradiotherapy and Radiotherapy Alone Following Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck
In this study, male to female ratio was 4:1 and mean age of patients were 54.7 ±9.1 and 56.6±7.9 in Arm A and Arm B respectively. At final follow-up, complete response was seen in 27 (53.3%) patients of Arm A and Arm B respectively. Response rate was significant (p<0.05) for both the Arms. Acute toxicities observed during induction chemotherapy were almost equal in both the Arms, but during radiotherapy, Arm A had more toxicity though it was statistically insignificant. Induction chemotherapy followed by concurrent chemoradiotherapy is more effective than induction chemotherapy followed by radiotherapy alone in loco-r...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Carrier Detection of Thalassaemia and Haemoglobinopathies in Tribal Population of Bangladesh
This study shows a high percentage of Haemoglobin E trait and Haemoglobin E disease. Beta thalassaemia trait is also higher in comparison with randomly selected general population of Bangladesh. After calculating the estimate burden of child born per year by Harding Weinberg equation, it was to be found that the significant result which shows that 1552 new haemoglobin E beta thalassaemia and 22 new beta thalassaemia patients born per year in the tribal population. So, the tribal population should be properly screened and counseled for thalassaemia and haemoglobinopathies. (Source: Bangladesh Medical Research Council Bulletin)
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Medical Errors and Patient Safety Education: Views of Intern Doctors
Medical errors and patient safety have become increasingly important in the area of medical research in the recent years. World health Organization and other international committees have long been recommending the early integration of education about errors and patient safety in undergraduate and graduate medical education. To integrate patient safety education into existing curriculum views of the doctors towards patient safety education is an important issue. This descriptive type of cross sectional study was carried out to explore the views of intern doctors regarding medical error and patient safety education in under...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

DPPH Free-radical Scavenging and Cytotoxic Activities of Leeamacrophylla
In this study,in vitroDPPH free radical scavenging activity, total phenolic content and total flavonoid content of methanol extract from the leaves ofL. macrophyllawere determined with using UV spectrophotometric method. Antioxidant activity of the crude extract was expressed as percentage of DPPH free radical inhibition and IC50 value ( μg/ml). The IC50 value ofL. macrophylla was found to be 152.40 μg/ml. Compared to standard ascorbic acid (4.36 μg/ml),L. macrophylla leaf extract has moderate antioxidant property. The total phenolic content was 65.75 mg/g of dry weight of extract, expressed as gallic acid equivalents. ...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Association of High Sensitive C - Reactive Protein with Severity of the Left Ventricular Systolic Dysfunction in Acute Anterior ST Elevation Myocardial Infarction
High Sensitive C-reactive protein (hs- CRP) is an established risk marker in coronary artery disease. It is a marker of inflammation activated early after Acute Myocardial Infarction (AMI) and its quantity depends upon extent of myocardial damage. Release of inflammatory marker occur after acute myocardial infarction leading to cardiac remodeling which clinically manifests as Heart failure (HF). Heart failure is a common complication after acute anterior myocardial infarction (AMI). The prevalence of post-infarct Left Ventricular Systolic Dysfunction (LVSD) ranges from 27 to 60 % and half of patients having early post-infa...
Source: Bangladesh Medical Research Council Bulletin - November 22, 2018 Category: International Medicine & Public Health Source Type: research

Human Leukocyte Antigen: Class I Allele Frequencies and Haplotype Distributionin a Tertiary Care Hospital in Bangladesh
Human leukocyte antigen (HLA) are cell surface glycoproteins encoded by Major Histocompatibility Complex (MHC) geneof human genome. HLA antigen frequency and haplotype distribution are useful for determining disease associations, origin, migration and genetic relationships between populations and predicting the outcome of transplantation. Thus, the present study was carried outto identify HLA class I (HLA-A and HLA-B) antigen and haplotype distribution among a selected Bangladeshi population. This retrospective study was conducted among 1070 individuals who were referred by cliniciansfor HLA typing at the Tissue Typing Lab...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Disseminated Herpes Zoster in a Patient with Acute Lymphoblastic Leukaemia: A case study
Varicella zoster virus (VZV) is a member of Herpesviridae family. It can cause two distinct clinical entities: varicella (chickenpox) and herpes zoster (shingles).1,2Herpes Zoster(HZ) is painful, vesicular rash in a limited area on one side of body due to the reactivation of latent VZV in dorsal root ganglia.Involvement of three or more dermatomes is known as disseminated zoster and seen in immunocompromised individuals.It can occur at any age. The risk of herpes zoster increases with old age and in patients with reduced cell mediated immunity such as haematological malignancies, immunosuppressive therapies, HIV infection ...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Outcome of Surgical Induction of Labourin a Combined Military Hospital
This study was aimed to assess the effectiveness and safety of surgical induction of labour in term and postdated pregnancy.This prospective clinical study was conducted in the in-patient Department of Obstetrics and Gynecology, Combined Military Hospital (CMH), Dhaka from July, 2005 to June 2006. A total of 100 pregnant women with term and postdated pregnancy were selected for the study by simple random sampling. The particulars of the patient, detailed menstrual and obstetric history, induction delivery interval, mode of delivery and foetal outcome and maternal complications were recorded. The results were analysed by St...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Gastroesophageal Reflux Disease: Prevalence and ItsRisk Factors in Rural Bangladesh
Gastroesophageal Reflux Disease (GERD) is a global disease, and evidence suggests that its prevalence is increasing. Prevalence estimates show considerable geographic variation.According to WHO, prevalence of GERD in far EastAsia currently consistently lower than 10%,which is 8-20% in India. No such population based dataare available in Bangladesh. Thus, the studywas designed to determine the prevalence of GERD and its risk factors inrural community of Bangladesh.This descriptive, cross-sectional study was carried outfrom January to June 2015 by using validated questionnaire through door to door interview among randomly se...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Perceptions on Breast Cancer Pattern: Medical Help Seeking Among Breast Cancer Patients
Perception on breast cancer influences the help seeking pattern of breast cancer patients. Negative perception causes delay in help seeking. Outcome or survival rate of breast cancer has a relation on perception. A cross sectional study was done during July 2015-June 2016, to assess the perception on breast cancer and to find out the help seeking pattern and extent of help seeking time among breast cancer patients. A total of 200 patients were selected following the convenient method of sampling from National Institute of Cancer Research and Hospital. Dhaka. Face to face interviews were taken from the diagnosed breast canc...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Cockroach Associated Foodborne Pathogens: Distribution and Antibiogram
Cockroaches are among the most common pests in public dwellings and health facilities. Owing to their close association with man and all his surroundings they are consideredas potential carrier and transmitter of human diseases. In hospital, cockroaches are the possible vector of nosocomial infection, specially for the transmission of drug resistant bacteria. The aim of the present study was to identify the major cockroach species, to isolate common foodborne pathogens from cockroach and to determine the antibiotic susceptibility pattern of isolated bacteria. This casecontrol study was conducted on cockroaches captured fro...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research