HLA-DQ2 and -DQ8 haplotypes frequency and diagnostic utility in celiac disease patients of Gaza strip, Palestine
ConclusionsAbsence of HLA-DQ2 and HLA-DQ8 genotyping in the workup of patients may result in CD misdiagnosis, particularly in a setting with poor histopathological diagnostic capacity. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - November 15, 2017 Category: Allergy & Immunology Source Type: research
Personalized medicine in rheumatology: the paradigm of serum autoantibodies
AbstractThe sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite identical genotypes, as well illustrated by discordant monozygotic twins. To recognize these differences, one of the easiest and most familiar examples of biomarkers capable of identifying and predicting the outcome of patients is represented by serum autoantibodies. In this review, we will describe the concept of personalized medicine and discuss the predictive, prognostic and preventive role of antinuclear antibo...
Source: Autoimmunity Highlights - July 12, 2017 Category: Allergy & Immunology Source Type: research
Chemiluminescent immunoassay technology: what does it change in autoantibody detection?
AbstractDiagnostic technology is rapidly evolving, and over the last decade, substantial progress has been made even for the identification of antibodies, increasingly approaching this type of diagnostic to that of automated clinical chemistry laboratory. In this review, we describe the analytical and diagnostic characteristics of chemiluminescence technology in its strength and in its applicability for a more rapid and accurate diagnosis of autoimmune diseases. The wide dynamic range, greater than that of immunoenzymatic methods, the high sensitivity and specificity of the results expressed in quantitative form, the high ...
Source: Autoimmunity Highlights - June 24, 2017 Category: Allergy & Immunology Source Type: research
Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods
ConclusionsDespite the efforts for harmonization, TgAb methods cannot be used interchangeably. Therefore, additional effort is required to improve analytical performance taking into consideration approved protocols and guidelines. Moreover, TgAb URL should be used with caution in the management of differentiated thyroid carcinoma patients since the presence and/or the degree of TgAb interference in Tg measurement has not yet been well defined. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - June 19, 2017 Category: Allergy & Immunology Source Type: research
Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice
ConclusionsAlthough band 3 peptides 241 –251 and 282–296 induced to the highest IL-10 production by CD4 T cells in vitro but fail to reverse the RBC autoantibody response in vivo. Modifications to improve solubility these peptides might help to modulate the immune response toward a T helper-2 profile and decrease the severity of anemi a. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - April 28, 2017 Category: Allergy & Immunology Source Type: research
A case of sarcoidosis with isolated hepatosplenic onset and development of inflammatory bowel disease during recovery stage
AbstractSarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system involvement at onset, while less than 10% has an isolated extrapulmonary localization. Here, we describe the case of an elderly patient with isolated hepato-splenic onset (multiple splenic lesions at imaging and cholestasis), and subsequent pulmonary involvement. The liver biopsy showed the presence of non-caseating granulomas, suggesting sarcoidosis. Despite the complete recove...
Source: Autoimmunity Highlights - April 28, 2017 Category: Allergy & Immunology Source Type: research
Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice
ConclusionsAlthough band 3 peptides 241 –251 and 282–296 induced to the highest IL-10 production by CD4 T cells in vitro but fail to reverse the RBC autoantibody response in vivo. Modifications to improve solubility these peptides might help to modulate the immune response toward a T helper-2 profile and decrease the severity of anemi a. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - April 28, 2017 Category: Allergy & Immunology Source Type: research
A case of sarcoidosis with isolated hepatosplenic onset and development of inflammatory bowel disease during recovery stage
AbstractSarcoidosis is a systemic disease characterized by an immune-mediated disorder, which leads to the development of non-caseating granulomas in the involved organs. More than 90% of patients with sarcoidosis present lungs and lymphatic system involvement at onset, while less than 10% has an isolated extrapulmonary localization. Here, we describe the case of an elderly patient with isolated hepato-splenic onset (multiple splenic lesions at imaging and cholestasis), and subsequent pulmonary involvement. The liver biopsy showed the presence of non-caseating granulomas, suggesting sarcoidosis. Despite the complete recove...
Source: Autoimmunity Highlights - April 28, 2017 Category: Allergy & Immunology Source Type: research
Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies
ConclusionsPAF-AH plasmatic activity is particularly up-regulated in LAC+ and in a β2GPI IgG+ patients, possibly representing an alternative prognostic biomarker for the therapeutic management of APS patients. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - March 25, 2017 Category: Allergy & Immunology Source Type: research
The universe of ANA testing: a case for point-of-care ANA testing
AbstractTesting for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in patients with low pre-test probability and use of negative ANA results to rule out underlying autoimmune disease. A positive result can lead to further diagnostic considerations. Currently, ANA tests are performed in centralized laborato...
Source: Autoimmunity Highlights - March 21, 2017 Category: Allergy & Immunology Source Type: research
