Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70 TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity
ConclusionsThe toxicology, pharmacodynamic and pharmacokinetic data in this preclinical study were helpful in designing the first in human study with K1-70 ™ administered to subjects with Graves’ disease. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - November 6, 2019 Category: Allergy & Immunology Source Type: research
Evolving liver inflammation in biochemically normal individuals with anti-mitochondria antibodies
ConclusionsBN/AMA+ individuals present an orchestrated increase in ELF score and humoral autoimmune response over time, indicating an opportunity for early therapeutic intervention and prevention in autoimmunity. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - October 30, 2019 Category: Allergy & Immunology Source Type: research
Antiphospholipid syndrome: a case report with an unusual wide spectrum of clinical manifestations
ConclusionBased on the patient ’s medical history and all the examination results, it was possible to make a diagnosis of primary APS and, starting from diagnosis of thrombocytopenia, we were allowed to conclude that all of manifestation were epi-phenomena of a unique clinical entity, rather than unrelated diseases. Though APS is one of the most common thrombocytophilias, unfortunately, it is not recognized often enough. The lack of prevention in undiagnosed patients may cause severe complications which can in turn result in the death of those patients. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - October 18, 2019 Category: Allergy & Immunology Source Type: research
Look granulomatosis with polyangiitis (GPA) straight in the face: missed opportunities leading to a delayed diagnosis
We report a case with GPA, which was diagnosed only after new and advancing symptoms belied the original diagnosis of bilateral facial palsy and aortic mural thrombus. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - September 16, 2019 Category: Allergy & Immunology Source Type: research
Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options
AbstractMultiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by focal or diffuse inflammation, demyelination, axonal loss and neurodegeneration. Brain atrophy can be seen in the earliest stages of MS, progresses faster compared to healthy adults, and is a reliable predictor of future physical and cognitive disability. In addition, it is widely accepted to be a valid, sensitive and reproducible measure of neurodegeneration in MS. Reducing the rate of brain atrophy has only recently been incorporated as a critical endpoint into the clinical trials of new or emerging disease m...
Source: Autoimmunity Highlights - August 9, 2019 Category: Allergy & Immunology Source Type: research
The clinical significance of atypical indirect immunofluorescence patterns on primate cerebellum in paraneoplastic antibody screening
ConclusionsAn atypical indirect immunofluorescence pattern on primate cerebellum in the screening for paraneoplastic antibodies has only very minor relevance with respect to paraneoplastic neurological syndromes or any other neurological disease, recommending clinicians to interpret the results of positive screening assays for such antibodies with care. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - July 24, 2019 Category: Allergy & Immunology Source Type: research
A new M23-based ELISA assay for anti-aquaporin 4 autoantibodies: diagnostic accuracy and clinical correlation
ConclusionsThis new ELISA method performed on a fully automated system, showed high sensitivity and absolute specificity, good CV in precision tests, and provided observer-independent quantitative results. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - June 18, 2019 Category: Allergy & Immunology Source Type: research
Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity
ConclusionNLRs and LMRs are simple non-invasive affordable independent markers of disease activity in UC. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - May 14, 2019 Category: Allergy & Immunology Source Type: research
Anti- β2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies exert similar pro-thrombotic effects in peripheral blood monocytes and endothelial cells
ConclusionsOur data support the significant and independent role of aPS/PT in the pathogenesis of the thrombotic events in APS patients, possibly adding new light to the therapeutic management of cases characterized by the sole presence of aPS/PT IgG antibodies. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - April 5, 2019 Category: Allergy & Immunology Source Type: research
Association of HLA-B27 and Behcet ’s disease: a systematic review and meta-analysis
ConclusionsThere is a significant correlation between HLA-B27 and Behcet ’s Disease, but it was weak. Environmental and genetic factors might determine which the “HLA-B27” alleles manifest Behcet’s disease progression. Future researches is required to perform about what factors can do to positively and separately influence Behcet’s disease. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - March 18, 2019 Category: Allergy & Immunology Source Type: research
Protective effect of TSLP and IL-33 cytokines in ulcerative colitis
ConclusionsIn this study, we showed decreased mRNA expression levels of TSLP and IL-33 in UC patients and also a negative correlation between expression of TSLP and IL-33 and severity of UC disease. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - March 13, 2019 Category: Allergy & Immunology Source Type: research
Regulatory B and T lymphocytes in multiple sclerosis: friends or foes?
AbstractCurrent clinical experience with immunomodulatory agents and monoclonal antibodies in principle has established the benefit of depleting lymphocytic populations in relapsing –remitting multiple sclerosis (RRMS). B and T cells may exert multiple pro-inflammatory actions, but also possess regulatory functions making their role in RRMS pathogenesis much more complex. There is no clear correlation of Tregs and Bregs with clinical features of the disease. Herein, we discus s the emerging data on regulatory T and B cell subset distributions in MS and their roles in the pathophysiology of MS and its murine model, experi...
Source: Autoimmunity Highlights - November 10, 2018 Category: Allergy & Immunology Source Type: research
Performance analysis of automated evaluation of antinuclear antibody indirect immunofluorescent tests in a routine setting
ConclusionsThe ANA IIF results reported by the EPa software are in very good agreement with the results reported by the observer with respect to being negative/positive, pattern recognition and titer, making automated ANA IIF evaluation an objective and time-efficient tool for routine testing. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - September 21, 2018 Category: Allergy & Immunology Source Type: research
Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report
ConclusionDental focus of occult infection may be a prime cause/trigger of autoimmune disorders and inflammatory disorders, requiring surgical intervention to remove. Ozone therapy, little known in conventional medicine, has been shown in the literature and in this case to be a powerful and safe immune modulator and anti-infective agent. This case has significant relevance across the entire spectrum of both medical and dental practice. It also emphasizes the need for individualized assessment and treatment rather than symptomatic pharmacological approaches treating a “disease” rather than the patient. Subclinical denta...
Source: Autoimmunity Highlights - June 30, 2018 Category: Allergy & Immunology Source Type: research
