Anti-phospholipid IgG antibodies detected by line immunoassay differentiate patients with anti-phospholipid syndrome and other autoimmune diseases
ConclusionsaD1/aD4 –5 (ELISA) and aPG IgG (LIA) differentiate APS from SARD patients. PG appears to interact with β2GPI of APS patients and exposes D1 thereof for disease-specific aPL binding in LIA. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - May 29, 2018 Category: Allergy & Immunology Source Type: research
Rhabdomyolysis secondary to systemic lupus erythematosus
We present a case report of a patient with an SLE exacerbation as well as concurrent rhabdomyolysis with massively elevated CPK (304,700 U/L). Though a rarely reported effect of SLE, rhabdomyolysis can be severe and potentially lethal secondary or concurrent to an acute SLE episode. This case report demonstrates the association between SLE and rhabdomyolysis, which is not well described in the current literature. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - April 6, 2018 Category: Allergy & Immunology Source Type: research
Isolated acute lupus pneumonitis as the initial presentation of systemic lupus erythematosus in an 8-year-old girl
AbstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations. One of the rare and mortal complications is acute lupus pneumonitis, which is reported very rarely, especially in childhood. Herein, we report an 8-year-old girl with isolated acute lupus pneumonitis as the initial presentation that required a lung biopsy for diagnosis. Although she had improvement with the administration of steroids, steroid treatment was reduced due to the drug ’s side effects resulting in the addition of azathioprine and mycophenolate mofetil to the treatment regimen. After the n...
Source: Autoimmunity Highlights - March 27, 2018 Category: Allergy & Immunology Source Type: research
Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves ’ disease
ConclusionsThe diagnostic performance of ELiA™-TSH-R assay is comparable to that of some current TRAb assays. It may be adopted into clinical practice for the differential diagnosis of hyperthyroidism, to screen for transient hyperthyroidism, and to monitor disease activity and treatment effects. (Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - February 12, 2018 Category: Allergy & Immunology Source Type: research
Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome
(Source: Autoimmunity Highlights)
Source: Autoimmunity Highlights - February 10, 2018 Category: Allergy & Immunology Source Type: research
Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation
AbstractVitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D deficiency may have a causative ro...
Source: Autoimmunity Highlights - December 26, 2017 Category: Allergy & Immunology Source Type: research
Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment
AbstractThe clinical success of anti-CD20 monoclonal antibody (mAb)-mediated B cell depletion therapy has contributed to the understanding of B cells as major players in several autoimmune diseases. The first therapeutic anti-CD20 mAb, rituximab, is a murine –human chimera to which many patients develop antibodies and/or experience infusion-related reactions. A second generation of anti-CD20 mAbs has been designed to be more effective, better tolerated, and of lower immunogenicity. These include the humanized versions: ocrelizumab, obinutuzumab, and v eltuzumab, and the fully human, ofatumumab. We conducted a literature ...
Source: Autoimmunity Highlights - November 16, 2017 Category: Allergy & Immunology Source Type: research
