Relationships between autism spectrum disorder and intolerance of uncertainty
Autism Research, EarlyView. (Source: Autism Research)
Source: Autism Research - January 7, 2018 Category: Psychiatry Source Type: research
---
Autism Research, Ahead of Print. (Source: Autism Research)
Source: Autism Research - January 7, 2018 Category: Psychiatry Source Type: research
Enhancing interactions during daily routines: A randomized controlled trial of a web ‐based tutorial for parents of young children with ASD
Children with Autism Spectrum Disorder (ASD) often experience difficulty participating in everyday home routines, such as bed time or bath time. This randomized controlled trial examined the efficacy of an interactive, web‐based parenting tutorial for improving children's engagement in daily routines (i.e., proximal outcomes) as well improving children's social communication and parenting efficacy and stress (i.e., broad outcomes). Parents of children with ASD between 18 and 60 months were randomly assigned to the Tutorial group (n = 52) or the Control group (n = 52). All parents completed questionnaires at basel...
Source: Autism Research - January 7, 2018 Category: Psychiatry Authors: Lisa V. Iba ñez, Kenneth Kobak, Amy Swanson, Lisa Wallace, Zachary Warren, Wendy L. Stone Tags: Research Article Source Type: research
Proneness to guilt, shame, and pride in children with Autism Spectrum Disorders and neurotypical children
Self‐conscious emotions (e.g., guilt, shame, and pride) are complex emotions that require self‐reflection and self‐evaluation, and are thought to facilitate the maintenance of societal norms and personal standards. Despite the importance of self‐conscious emotions, most research has focused on basic emotion processing in children with Autism Spectrum Disorders (ASD). Therefore, in the present study, we used the Test of Self‐Conscious Affect for Children (TOSCA‐C) to assess proneness to, or propensity to experience, the self‐conscious emotions guilt, shame, and pride in children with ASD and neurotypical child...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Denise Davidson, Elizabeth Hilvert, Ieva Misiunaite, Michael Giordano Tags: Research Article Source Type: research
A pilot study of high ‐dose intravenous immunoglobulin 5% for autism: Impact on autism spectrum and markers of neuroinflammation
In this study, participants were recruited based on a diagnosis of autistic disorder, Asperger's disorder, or pervasive developmental disorder not otherwise specified. Participants also showed evidence of immune dysfunction based on abnormal levels of specific biomarkers, including CD40 ligand (CD154), lymphocyte stimulation, and T or B cell dysfunction. Of 17 screened patients, 14 completed the trial and received IVIG treatment (1 g/kg dose) for ten 21‐day treatment cycles. The primary endpoint was disease improvement assessed using standardized cognitive and behavioral tests (Children's Communication Checklist [CCC‐2...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Isaac R. Melamed, Melinda Heffron, Alessandro Testori, Kellie Lipe Tags: Research Article Source Type: research
Influence of family demographic factors on social communication questionnaire scores
This study examined the effect of demographic factors on Social Communication Questionnaire (SCQ) scores in children aged 30–68 months. Diagnoses of ASD were made after a gold standard evaluation that included the Autism Diagnostic Observation Schedule (ADOS), and the Autism Diagnostic Interview Revised (ADI‐R). The relationship of demographic variables to SCQ scores was compared in two source populations: (a) children recruited from clinical and educational sources serving children who have ASD or other developmental disorders (CE) and (b) children recruited from birth certificates to represent the general population ...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Steven A. Rosenberg, Eric J. Moody, Li ‐Ching Lee, Carolyn DiGuiseppi, Gayle C. Windham, Lisa D. Wiggins, Laura A. Schieve, Caroline M. Ledbetter, Susan E. Levy, Lisa Blaskey, Lisa Young, Pilar Bernal, Cordelia R. Rosenberg, M. Daniele Fallin Tags: Research Article Source Type: research
Effects of Parent ‐Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non‐Randomized Controlled Trial
To evaluate the effects of a 26‐week, high‐intensity, parent‐implemented Early Start Denver Model (P‐ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P‐ESDM group (n = 23) were recruited from 1.5‐ to 2.5‐year‐old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age‐matched toddlers with ASD (n = 20) was recruited from other areas. Subjects of the P‐ESDM group attended 1.5‐hr parent coaching per week for 26 weeks, and...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Bingrui Zhou, Qiong Xu, Huiping Li, Ying Zhang, Yi Wang, Sally J. Rogers, Xiu Xu Tags: Research Article Source Type: research
Goal prediction in 2 ‐year‐old children with and without autism spectrum disorder: An eye‐tracking study
This study examined the predictive reasoning abilities of typically developing (TD) infants and 2‐year‐old children with autism spectrum disorder (ASD) in an eye‐tracking paradigm. Participants watched a video of a goal‐directed action in which a human actor reached for and grasped one of two objects. At test, the objects switched locations. Across these events, we measured: visual anticipation of the action outcome with kinematic cues (i.e., a completed reaching behavior); goal prediction of the action outcome without kinematic cues (i.e., an incomplete reach); and latencies to generate predictions across these tw...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Sheila Krogh ‐Jespersen, Zsuzsa Kaldy, Annalisa Groth Valadez, Alice S. Carter, Amanda L. Woodward Tags: Research Article Source Type: research
Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents
Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FRα) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls. Overall, 76% of the affected children, 75% of the unaffected siblings, 69% of fathers and 59% of mothers were positive for either blocking or binding Ab, whereas the prevalence of this Ab in the normal controls was 29%. The Ab was highly prevalent in affected families includin...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Edward V. Quadros, Jeffrey M. Sequeira, W. Ted Brown, Clifford Mevs, Elaine Marchi, Michael Flory, Edmund C. Jenkins, Milen T. Velinov, Ira L. Cohen Tags: Short Report Source Type: research
NREM sleep EEG activity and procedural memory: A comparison between young neurotypical and autistic adults without sleep complaints
Delta EEG activity (0.75–3.75 Hz) during non‐Rapid eye movement (NREM) sleep reflects the thalamo‐cortical system contribution to memory consolidation. The functional integrity of this system is thought to be compromised in the Autism spectrum disorder (ASD). This lead us to investigate the topography of NREM sleep Delta EEG activity in young adults with ASD and typically‐developed individuals (TYP). The relationship between Delta EEG activity and sensory‐motor procedural information was also examined using a rotary pursuit task. Two dependent variables were computed: a learning index (performance increase across...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Annie ‐Claude Rochette, Isabelle Soulières, Claude Berthiaume, Roger Godbout Tags: Research Article Source Type: research
Developmental social communication deficits in the Shank3 rat model of phelan ‐mcdermid syndrome and autism spectrum disorder
This study leveraged a new rat model of Shank3 deficiency to assess complex behavioral phenomena, unique to rats, which display a richer social behavior repertoire than mice. Uniquely detectable emissions of ultrasonic vocalizations (USV) in rats serve as situation‐dependent affective signals and accomplish important communicative functions. We report, for the first time, a call and response acoustic playback assay of bidirectional social communication in juvenile Shank3 rats. Interestingly, we found that Shank3‐deficient null males did not demonstrate the enhanced social approach behavior typically exhibited following...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Elizabeth L. Berg, Nycole A. Copping, Josef K. Rivera, Michael C. Pride, Milo Careaga, Melissa D. Bauman, Robert F. Berman, Pamela J. Lein, Hala Harony ‐Nicolas, Joseph D. Buxbaum, Jacob Ellegood, Jason P. Lerch, Markus Wöhr, Jill L. Silverman Tags: Research Article Source Type: research
Measurement properties of tools used to assess depression in adults with and without autism spectrum conditions: A systematic review
Depression is the most commonly experienced mental health condition in adults with autism spectrum conditions (ASC). However, it is unclear what tools are currently being used to assess depression in ASC, or whether tools need to be adapted for this group. This systematic review therefore aimed to identify tools used to assess depression in adults with and without ASC, and then evaluate these tools for their appropriateness and measurement properties. Medline, PsychINFO and Web of Knowledge were searched for studies of depression in: (a) adults with ASC, without co‐morbid intellectual disability; and (b) adults from the ...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: S. A. Cassidy, L. Bradley, E. Bowen, S. Wigham, J. Rodgers Tags: Research Article Source Type: research
Parent and clinician agreement regarding early behavioral signs in 12 ‐ and 18‐month‐old infants at‐risk of autism spectrum disorder
Parent and clinician agreement regarding early behavioral signs of Autism Spectrum Disorder (ASD) in children from a high‐risk cohort (siblings of children diagnosed with ASD, n = 188) was examined. Infants were assessed prospectively at 12 and 18 months of age using the clinician administered Autism Observational Scale for Infants (AOSI) and the Autism Parent Screen for Infants (APSI) and underwent a blind independent diagnostic assessment for ASD at 36 months of age. Direct comparison of parent and clinician ratings showed poor agreement on all early behavioral signs, with parent‐reported symptoms being better ab...
Source: Autism Research - January 1, 2018 Category: Psychiatry Authors: Lori ‐Ann R. Sacrey, Lonnie Zwaigenbaum, Susan Bryson, Jessica Brian, Isabel M. Smith, Wendy Roberts, Peter Szatmari, Tracy Vaillancourt, Caroline Roncadin, Nancy Garon Tags: Research Article Source Type: research
Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18 ‐month randomized clinical trial
Autism Research,Volume 11, Issue 3, Page 519-530, March 2018. (Source: Autism Research)
Source: Autism Research - December 29, 2017 Category: Psychiatry Source Type: research
