Investigation of chromosomal alterations in patients with Alzheimer's disease in the state of Amazonas, Brazil
ABSTRACT Alzheimer's disease (AD) has as its main characteristic the deterioration of cerebral functions. Its etiology is still complex and undefined despite the progress made in understanding its neurological, infectious, biochemical, genetic and cytogenetic mechanisms. Considering this, the aim of this study was to investigate the presence of chromosomal alterations in the peripheral blood lymphocytes, and to verify if there was a high frequency of these alterations in patients diagnosed with AD at the University Hospital Get úLio Vargas Outpatient Clinic Araújo Lima in Manaus, Amazonas, Brazil. Among the nine patients...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Vitamin D, vitamin D binding protein, vitamin D receptor levels and cardiac dysautonomia in patients with multiple sclerosis: a cross-sectional study
Conclusion: There was no correlation between orthostatic hypotension, supine hypertension and systolic BPV values and serum vitamin D, VDBP and VDR in MS patients. Future prospective studies with large number of patients may help us to better understand the relationship between vitamin D and the autonomic nervous system.RESUMO A vitamina D é um hormônio esteroide pleiotrópico que modula o equilíbrio autonômico. Sua deficiência tem sido descrita como fator de risco ambiental para esclerose múltipla (EM). O objetivo deste estudo foi investigar os níveis séricos de vitamina D, proteína de ligação à vitamina D (VD...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Prevalence of oropharyngeal dysphagia in hereditary spastic paraplegias
Conclusions: Clinically significant oropharyngeal dysphagia was only present in complicated forms of HSP Patients with SPG11 and CTX had the highest risks for dysphagia, suggesting that surveillance of swallowing function should be part of the management of patients with these disorders.RESUMO As paraparesias esp ásticas hereditárias (PEH) são um grupo de doenças genéticas caracterizado por espasticidade dos membros inferiores com ou sem características neurológicas adicionais. A disfunção da deglutição é pouco estudada nas PEH e sua presença pode levar a complicações respiratórias e nutricio nais significa...
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Evaluation of swallowing in patients with hereditary spastic paraplegias
(Source: Arquivos de Neuro-Psiquiatria)
Source: Arquivos de Neuro-Psiquiatria - January 10, 2020 Category: Neurology Source Type: research
Reply: Intracranial aneurysm diameter and risk of rupture
Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.RESUMO El s índrome de Ofelia describe la asociación entre pérdida de memoria y enfermedad de Hodgkin, en memoria del personaje de La Tragedia de Hamlet, Príncipe de Dinamarca, de William Shakespeare. Sin embargo, existen diferencias entre ambos. Objetivo: Revisar los orígenes y usos del epónimo a travé s del artículo original, su relación con el personaje y los autoanticuerpos relacionados...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Intracranial aneurysm diameter and risk of rupture
Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.RESUMO El s índrome de Ofelia describe la asociación entre pérdida de memoria y enfermedad de Hodgkin, en memoria del personaje de La Tragedia de Hamlet, Príncipe de Dinamarca, de William Shakespeare. Sin embargo, existen diferencias entre ambos. Objetivo: Revisar los orígenes y usos del epónimo a travé s del artículo original, su relación con el personaje y los autoanticuerpos relacionados...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Neurocysticercosis and HIV Infection
Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.RESUMO El s índrome de Ofelia describe la asociación entre pérdida de memoria y enfermedad de Hodgkin, en memoria del personaje de La Tragedia de Hamlet, Príncipe de Dinamarca, de William Shakespeare. Sin embargo, existen diferencias entre ambos. Objetivo: Revisar los orígenes y usos del epónimo a travé s del artículo original, su relación con el personaje y los autoanticuerpos relacionados...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Acute hyperammonemic encephalopathy secondary to ornithine transcarbamylase deficiency in a child: findings in diagnostic imaging
Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.RESUMO El s índrome de Ofelia describe la asociación entre pérdida de memoria y enfermedad de Hodgkin, en memoria del personaje de La Tragedia de Hamlet, Príncipe de Dinamarca, de William Shakespeare. Sin embargo, existen diferencias entre ambos. Objetivo: Revisar los orígenes y usos del epónimo a travé s del artículo original, su relación con el personaje y los autoanticuerpos relacionados...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Brachial and sacral plexus neurolymphomatosis - unusual regions for disease relapses
Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.RESUMO El s índrome de Ofelia describe la asociación entre pérdida de memoria y enfermedad de Hodgkin, en memoria del personaje de La Tragedia de Hamlet, Príncipe de Dinamarca, de William Shakespeare. Sin embargo, existen diferencias entre ambos. Objetivo: Revisar los orígenes y usos del epónimo a travé s del artículo original, su relación con el personaje y los autoanticuerpos relacionados...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
The poor insane Ophelia: reconsidering Ophelia syndrome
Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.RESUMO El s índrome de Ofelia describe la asociación entre pérdida de memoria y enfermedad de Hodgkin, en memoria del personaje de La Tragedia de Hamlet, Príncipe de Dinamarca, de William Shakespeare. Sin embargo, existen diferencias entre ambos. Objetivo: Revisar los orígenes y usos del epónimo a travé s del artículo original, su relación con el personaje y los autoanticuerpos relacionados...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Overcoming bashfulness: how cocaine aided Freud to summon the courage to meet Charcot
ABSTRACT Jean-Martin Charcot, the most celebrated neurologist of the 19th century, had a profound influence on Sigmund Freud's career. Freud spent the winter of 1885-1886 working in Charcot's neurology department in Paris. During this period, he went to Charcot's house on several occasions to participate in the very famous Tuesday soir ées under the guidance of Gilles de la Tourette. Freud was always very proud to be invited and curious to meet the Parisian intellectual elite. On these occasions, however, he was very apprehensive and made frequent use of cocaine. Due to anxiety and the need to appear creative in front of ...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Alzheimer's disease and sleep disturbances: a review
ABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. The review also makes a c...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Aneurysmal subarachnoid hemorrhage: current concepts and updates
ABSTRACT Aneurysmal subarachnoid hemorrhage is a condition with a considerable incidence variation worldwide. In Brazil, the exact epidemiology of aneurysmal SAH is unknown. The most common presenting symptom is headache, usually described as the worst headache ever felt. Head computed tomography, when performed within six hours of the ictus, has a sensitivity of nearly 100%. It is important to classify the hemorrhage based on clinical and imaging features as a way to standardize communication. Classification also has prognostic value. In order to prevent rebleeding, there still is controversy regarding the ideal blood pre...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
Surgical treatment of drug-resistant epilepsy caused by gliomas in eloquent areas: experience report
Conclusion: There was a statistically significant association between the EOR and the Engel score for epilepsy control: an EOR< 70 was associated with Engel II, III, IV and an EOR> 90 was associated with Engel I. Eloquent area gliomas can safely be resected when surgeons use not only microsurgical anatomy concepts but also brain mapping.RESUMO Epilepsia refrat ária secundária a tumores cerebrais são geralmente causadas por gliomas de baixo grau. Esse grupo de tumor é frequentemente localizado em áreas eloquentes do cérebro como na insula, córtex rolândico e área motora suplementar; e sua ressecção apresent...
Source: Arquivos de Neuro-Psiquiatria - December 6, 2019 Category: Neurology Source Type: research
