PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
CONCLUSION: Our study confirms the concept of a shift towards a more antiapoptotic transcriptional context during tumour progression in RCCs. Furthermore, it shows that caspase-2 participates in chemotherapy-induced apoptosis in RCCs although it is not mandatory for it. Additionally, inhibition of antiapoptotic BCL-2 family members might provide a possible way to overcome chemotherapy resistance of RCCs.
PMID: 20208132 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Promiscuous behavior of HPV16E6 specific T cell receptor beta chains hampers functional expression in TCR transgenic T cells, which can be restored in part by genetic modification.
CONCLUSION: Promiscuous behavior of the HPV16E6 specific TCRbeta chain can in part be forced back into specific action in TCR transgenic T cells by codon modification in combination with the inclusion of an extra cysteine in the TCR chains.
PMID: 20208133 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value - conclusions from 924 cases of two independent series.
CONCLUSIONS: This is the largest study to date demonstrating in two independent series that HER2 expression is not related to gastric cancer patient prognosis and that only a very small subgroup of intestinal type GC may potentially respond to HER2 targeting therapy. Due to prominent intratumoural heterogeneity of HER2 expression in GC, HER2 testing in endoscopic biopsies before treatment will be prone to false negative results.
PMID: 20208134 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Novel in vitro assays for the characterization of EMT in tumourigenesis.
CONCLUSION: The Spindle Index and the novel chemoattractant assay are valuable adjunctive assays for objective characterization of EMT changes during tumourigenesis.
PMID: 20208135 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Different subcellular localization of ALCAM molecules in neuroblastoma: Association with relapse.
CONCLUSION: Assessment of ALCAM localization by immunohistochemistry may help to identify patients who, in the absence of negative prognostic factors, are at risk of relapse and require a more careful follow-up.
PMID: 20208136 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Microarray analysis of suppression subtracted hybridisation libraries identifies genes associated with breast cancer progression.
CONCLUSIONS: The combination of subtracted cDNA libraries and microarray analysis has thus identified potential diagnostic/prognostic biomarkers and targets for cancer therapy, which have not been identified from common prognostic gene signatures.
PMID: 20208137 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Pre T-cell receptor alpha (pTalpha) expression patterns and functional analysis in human T-cell lymphoblastic leukemia.
CONCLUSION: Sensitivity of thymic T-ALLs to PP1 clearly underlines the impact of pTalpha mediated proliferation in this leukemic sub-type. In addition, p56(Lck) represents also independently of pTalpha a promising therapeutical target for the src-kinase inhibitors in neoplastic lymphoid diseases.
PMID: 20208138 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides.
CONCLUSION: We implemented a virtual microscopy system allowing highly efficient automated prescreening and archiving of biomarker-stained slides. Based on the initial results, we will evaluate the performance of our system in large epidemiologic studies against disease endpoints.
PMID: 20208139 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
The TFIIH subunit p89 (XPB) localizes to the centrosome during mitosis.
CONCLUSIONS: Our observations suggest a so far unappreciated role for p89 in cell cycle regulation, and may be the structural basis for a long known, but hitherto unexplained interaction between p89 and tubulin.
PMID: 20208140 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Gene promoter methylation patterns throughout the process of cervical carcinogenesis.
CONCLUSION: Methylation of previously reported cervical cancer specific genes frequently occurs in normal epithelium. However, frequency of methylation increases during cervical carcinogenesis, with CCNA1 and DAPK as the best markers to distinguish normal/LSIL from HSIL/cancer lesions.
PMID: 20208141 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
The pan-deacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis.
Authors: Di Fazio P, Schneider-Stock R, Neureiter D, Okamoto K, Wissniowski T, Gahr S, Quint K, Meissnitzer M, Alinger B, Montalbano R, Sass G, Hohenstein B, Hahn EG, Ocker M
Abstract
Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced. HepG2 (p53wt) and Hep3B (p53null) responded to panobinostat treatment with a reduction of cell proliferation and a significant increase in apoptotic c...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
WNT-pathway activation in IBD-associated colorectal carcinogenesis: potential biomarkers for colonic surveillance.
CONCLUSION: In contrast to previous findings, our results suggest activation of the Wnt-pathway in the early phase of colitis-associated carcinogenesis. Furthermore, as Wnt activation was observed in 50% of the IBD-NE cases, nuclear beta-catenin may facilitate detection of neoplasia.
PMID: 20208143 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Relevance of germline mutation screening in both familial and sporadic head and neck paraganglioma for early diagnosis and clinical management.
CONCLUSION: In contrast to other series, this cohort of Spanish patients showed many SDHB mutations. Sporadic cases with germline mutation are frequent and underline the importance of mutational screening of all PGL patients, allowing the identification of relatives at risk and the early diagnosis of the disease, reducing or avoiding morbidity.
PMID: 20208144 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
A peptide antagonist of the ErbB1 receptor inhibits receptor activation, tumor cell growth and migration in vitro and xenograft tumor growth in vivo.
Authors: Xu R, Povlsen GK, Soroka V, Bock E, Berezin V
Abstract
The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in tumorigenesis and cancer disease progression, and therefore has become an attractive target for structure-based drug design. ErbB receptors are activated by ligand-induced homo- and heterodimerization. Structural studies have revealed that ErbB receptor dimers are stabilized by receptor-receptor interactions, primarily mediated by a region in the second extracellular domain, termed the "dimerization arm". The present study is the first biological c...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture.
CONCLUSION: In conclusion, we provide the first direct evidence that oestrogenic molecules can influence proliferation of SPNC, offering future strategies in the control of this neoplasia via selective ER modulators.
PMID: 20364070 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
