Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression.
Authors: Weaver BA, Silk AD, Cleveland DW
PMID: 18791276 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
TnT: T antigen and telomerase, an explosive route to cancer.
Authors: Ray FA
PMID: 18791277 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
The "aneuploidy-modified mutator-phenotype" theory of malignant tumors.
Authors: Bignold LP
PMID: 18791278 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Neoplasia, ageing, and genetic instability due to defective caretaker genes.
Authors: Hoehn H, Neveling K, Endt D, Melcher R, Schindler D
PMID: 18791279 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
SV40 Tag/p53 complexes actively promote malignant cell growth of human mesothelial cells.
Authors: Bocchetta M, Carbone M
PMID: 18853526 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Tumour-associated transcripts and EGFR deletion variants in colorectal cancer in primary tumour, metastases and circulating tumour cells.
Authors: Lankiewicz S, Rother E, Zimmermann S, Hollmann C, Korangy F, Greten TF
Abstract
The clinical relevance of circulating tumour cells (CTC) in peripheral blood of patients with colorectal cancer (CRC) has been described as an independent prognostic factor useful to monitor drug effects and clinical status. The aim of the present study was to compare the epidermal growth factor receptor (EGFR) status of primary tumour, related metastases and CTC of patients with CRC. Therefore, in addition to EGFR, the tumour-associated transcripts gastrointestinal tumour-associated antigen 733-2 (GA733-2) and carcino...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Immunohistochemical detection and localization of somatostatin receptor subtypes in prostate tissue from patients with bladder outlet obstruction.
Authors: Montironi R, Cheng L, Mazzucchelli R, Morichetti D, Stramazzotti D, Santinelli A, Moroncini G, Galosi AB, Muzzonigro G, Comeri G, Lovisolo J, Cosciani-Cunico S, Bono AV
Abstract
BACKGROUND AND AIM OF THE STUDY: Scant information on the cellular distribution of the five somatostatin receptor (SSTR) subtypes in the normal prostate and in neoplasms of the prostate has been reported in very few studies in which techniques, such as in situ hybridization histochemistry, autoradiography, and more recently immunohistochemistry, have been applied. The aim of the study was to examine immunohistochemically t...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Relationship between dyskerin expression and telomerase activity in human breast cancer.
In conclusion, our results indicated that, beside its effect on ribosome biogenesis, the levels of dyskerin in cancer cells modulate telomerase activity through the regulation of TERC levels, independently of TERT expression. This should be taken into consideration when utilizing TERT expression as a surrogate indicator of telomerase activity in tumour pathology.
PMID: 18936525 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
The doppel (Dpl) protein influences in vitro migration capability in astrocytoma-derived cells.
In this study, we aimed to investigate in vitro the potential involvement of Dpl in the tumor cell migration: to this purpose, Dpl expression was reduced in the IPDDC-A2 astrocytoma-derived cell line, by means of antisense and siRNA approaches; migration rates were then evaluated by means of a scratch wound healing assay. As a result, the cellular migration was sensibly reduced after Dpl silencing. Following a complementary approach, in HeLa cells, showing very low endogenous Dpl expression, the protein expression was induced by transfection and stabilization of an eukaryotic expression vector containing the doppel gene co...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Genomic instability in context of the chromosomal theory.
Authors: Fabarius A, Duesberg P, Giehl M, Seifarth W, Hochhaus A, Hehlmann R
PMID: 18936527 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Induction of spindle multipolarity by centrosomal cluster inhibition.
Authors: Krämer A, Raab MS, Rebacz B
PMID: 18936528 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Spectral karyotyping and SNP microarray analysis define uniparental disomy (UPD) as a novel mutational mechanism in MSI- and CSI-colorectal cancers.
Authors: Melcher R, Zopf W, Hartmann E, Rosenwald A, Hoehn H, Schmid M, Kudlich T, Scheurlen M, Luehrs H
PMID: 18936529 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Missing evidences in cancer genetics: the retinoblastoma paradigm.
Authors: Mastrangelo D, Di Leonardo A, Lentini L, De Francesco S, Hadjistilianou T
PMID: 18936530 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Evaluation of DNA-ploidy heterogeneity in gastric cancers.
Authors: Osterheld MC, Laurini RN, Saraga EP, Bosman FT
PMID: 18936531 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Patterns of genome dynamics and cancer evolution.
Authors: Heng HH, Stevens JB, Lawrenson L, Liu G, Ye KJ, Bremer SW, Ye CJ
PMID: 18936532 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
