Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death.
CONCLUSION: Dual function microtubule-associated (MAP) and mitochondria-associated (MtAP) proteins generated by prolonged mitotic arrest trigger mitochondrial-induced mitotic cell death. This is a potential mechanism to prevent minimal survivable aneuploidy resulting from an aberrant cell division and cancers in general at their earliest common origin.
PMID: 19759419 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
CONCLUSION: These data support a role for cytotoxic T cells in the prevention of early metastasis of melanoma to the draining lymph nodes.
PMID: 19759420 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Functional implication of Netrin expression in malignant melanoma.
CONCLUSION: Our study suggests that Netrin-1 promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma.
PMID: 19940358 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.
CONCLUSION: Plex-B1 assumes a predictive value for unfavourable outcome when co-expressed with Met.
PMID: 19940359 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation.
Authors: Hassan M, Feyen O, Grinstein E
Abstract
Renal cell carcinoma (RCC) is a prototype of a chemo refractory tumour. It remains the most lethal of the common urologic cancers and is highly resistant to conventional therapy. Here, we confirmed the efficiency of anti-Fas monoclonal antibody (CH11) as alternative therapeutic approach for the treatment of RCC and investigated the molecular mechanism(s), whereby CH11 induces apoptosis of RCC cells. The present study shows an essential role for apoptosis signal-regulating kinase 1 (ASK1), together with both c-jun-N-terminal kinase (JNK) and p38 pathways, and...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB.
CONCLUSIONS: COX-2 inhibitors prevent chemoresistance development in breast cancer cells by inhibiting P-gp expression and function by a mechanism that involves PGH2 generation and NF-kappaB activation.
PMID: 19940361 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Gene expression of ERbeta isoforms in laser microdissected human breast cancers: implications for gene expression analyses.
CONCLUSION: With the technology now available, we suggest a more refined approach be adopted to help resolve some of the controversy surrounding ERbeta.
PMID: 19940362 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines.
CONCLUSION: The results suggest that COX-2 has an impact on transcriptional regulation of E-cadherin in gastric cancer and our findings further highlight the intriguing nature of EOGCs which appear to have a molecular phenotype distinct from conventional gastric cancer. In addition, our findings also suggest that reduction of COX-2 using nonsteroidal anti-inflammatory drugs in gastric cancer chemoprevention may only be relevant for older patients.
PMID: 19940363 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients.
CONCLUSION: Our results suggest that methylation of multiple genes plays an important role in prognosis of breast cancer. Our study not only describes the association of methylation mediated silencing of multiple genes with the severity of disease, but also drives to speculate the molecular crosstalk between genes or genetic pathways regulated by them individually.
PMID: 19940364 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
How to calculate the goodness-of-fit of a fractal dimension.
Authors: Albregtsen F
PMID: 19940365 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Goodness-of-fit of the fractal dimension as a prognostic factor.
Authors: Metze K, Lorand-Metze I, Leite NJ, Adam RL
PMID: 19940366 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells.
CONCLUSION: These findings suggest that inhibition of the PI3K pathway activates AR signaling. Despite the increase in AR signaling which has proliferative effects, the result of PI3K pathway inhibition is antiproliferative. These findings suggest that the PI3K pathway is dominant over AR signaling in prostate cancer cells which should be considered in developing novel therapeutic strategies for prostate cancer.
PMID: 20203370 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
The second wave of quantitative pathology.
Authors: Meijer G
PMID: 20203371 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Validation of a fully automated HER2 staining kit in breast cancer.
CONCLUSION: Fully-automated HER2 staining with the monoclonal antibody in the Oracle kit shows a high level of agreement with manual staining by the polyclonal antibody in the HercepTest. Although Oracle shows in general some more cytoplasmic staining and may be slightly less sensitive in picking up HER2 amplified cases, it shows a higher specificity and may be considered as an alternative method to evaluate the HER2 expression in breast cancer with potentially less analytical variability.
PMID: 20203372 [PubMed - indexed for MEDLINE] (Source: Analytical Cellular Pathology)
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
Staphylococcal SSL5 binding to human leukemia cells inhibits cell adhesion to endothelial cells and platelets.
In this study, we show that SSL5 targets HL-60 cells. Binding of SSL5 was rapid and without observed toxicity. Competition of SSL5 with the binding of three anti-PSGL-1 antibodies and P-selectin to HL-60 cells identified PSGL-1 as the ligand on HL-60 cells. Presence of sialyl Lewis x epitopes on PSGL-1 was crucial for its interaction with SSL5. Importantly, SSL5 not only inhibited the interaction of HL-60 cells with activated endothelial cells but also with platelets, which both play an important role in growth and metastasis of cancers. These data support the concept that SSL5 could be a lead in the search for novel strat...
Source: Analytical Cellular Pathology - November 25, 2014 Category: Cancer & Oncology Tags: Cell Oncol Source Type: research
