Case for diagnosis. Infiltrated areas on the trunk,
Abstract Leprosy is an infectious disease with chronic evolution, caused by Mycobacterium leprae, an acid-fast bacillus that mainly affects the skin and peripheral nervous tissue. Many of the clinical manifestations of leprosy can mimic connective tissue diseases. The authors present the case of a 49-year-old woman who had been treated for four years for systemic lupus erythematosus in a rheumatological service. Skin biopsy of a plaque on the inguinal region was compatible with borderline lepromatous leprosy associated with a type 1 lepra reaction. The patient is undergoing treatment with multibacillary multidrug therapy, ...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Case for diagnosis. Subcutaneous nodules in the plantar region,
Abstract The authors report a case of mobile and painful nodules on the bilateral plantar surface of a female patient referred by the rheumatology service, where she was being followed-up for rheumatoid arthritis. A nodule excision was performed for differential diagnosis and symptom relief; the histopathological analysis was compatible with a rheumatoid nodule. Although rheumatoid nodules are a common manifestation of rheumatoid arthritis, exclusive plantar involvement is seldom described in the literature. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Multisystemic fusariosis with fulminant evolution,
This report presents the case of a 13-year-old female patient with history of acute myeloid leukemia, who, after a bone marrow transplant, began to vomit and experienced rapidly progressive deterioration of consciousness, in addition to disseminated erythematous-violaceous macules, and some blisters with hemorrhagic content inside. Skin biopsy evidenced intravascular filamentous structures. A blood culture confirmed the presence of Fusarium oxysporum. Intravenous treatment with voriconazole was initiated. The patient evolved unfavorably with multiple necrotic skin lesions, ischemic brain lesions, and death. (Source: Anais ...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Clinical and epidemiological aspects of American cutaneous leishmaniasis with genital involvement,
Abstract Genital lesions are an unusual presentation of American cutaneous leishmaniasis. Conditions such as disseminated cutaneous leishmaniasis and HIV infection may be associated with genital involvement. The authors present five cases of American cutaneous leishmaniasis with genital lesions and discuss the clinical and epidemiological aspects observed in this case series. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Digital dermoscopy: a complementary method in the diagnosis of scabies,
Abstract Scabies is an ectoparasitosis caused by Sarcoptes scabiei var. hominis, characterized clinically by pruritic lesions in typical locations; the crusted form is a rare manifestation. The diagnosis is usually established based on the clinical picture, but dermoscopy can be an important complementary method, as it allows the observation of a brownish triangular structure with a hang-glider appearance. A case of crusted scabies is reported; the magnification of the images obtained by digital dermoscopy allowed the demonstration of a structure usually observed only with videodermoscopy. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Scalp cooling to prevent chemotherapy-induced alopecia,
Abstract Chemotherapy-induced alopecia causes an important impact on cancer patients and its risk of persistence is currently a considerable issue in cancer survivors. Of the various interventions proposed for the prevention of chemotherapy-induced alopecia, scalp cooling has emerged as an effective and safe strategy. This paper aims to provide an overview on scalp cooling and chemotherapy-induced alopecia prevention. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma,
The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epi...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Successful treatment of a patient with cutaneous co-infection caused by Mucor irregularis and Klebsiella pneumoniae,
Abstract The authors report a rare case of primary cutaneous mucormycosis caused by Mucor irregularis and cutaneous Klebsiella pneumoniae infections in a 67-year-old Chinese woman. After the administration of liposomal amphotericin B combined with cefoperazone/sulbactam sodium, the patient recovered. Invasive fungal infection combined with cutaneous bacterial infection should receive attention. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Multiple pilomatricomas in twins with Rubinstein-Taybi syndrome,
Abstract Pilomatricomas are benign tumors originating from the capillary matrix, which may present as solitary lesions or, less commonly, multiple. Myotonic dystrophy and familial adenomatous polyposis are the most frequently associated disorders with multiple pilomatricomas. There are few reports relating these tumors to other genetic syndromes. Rubinstein-Taybi syndrome is a rare autosomal dominant disorder characterized by intellectual disability and typical dysmorphic characteristics. There are five case reports relating to multiple pilomatricoma to Rubinstein-Taybi syndrome, an association that needs to be clarified. ...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Spitz nevus and infliximab: association or coincidence?,
Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Disseminated fusariosis in a patient with bone marrow aplasia,
Abstract Fusariosis is a superficial or systemic infection, which occurs mainly in immunocompromised hosts, especially in patients with hematological neoplasia; 70% – 75% of the cases present cutaneous manifestations. The disseminated form is rare and difficult to diagnose; even with specific treatment, the evolution is usually fatal. Currently, it is considered an emerging disease; in some centers, it is the second most common cause of invasive mycosis, after aspergillosis. The authors describe a case of a female patient with idiopathic bone marrow aplasia and disseminated fusariosis, who initially appeared to benefit f...
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Profile of the use of dermoscopy among dermatologists in Brazil (2018),
Conclusion: Dermoscopy is incorporated into the clinical practice of almost all Brazilian dermatologists, and it is recognized for increasing diagnostic certainty in different contexts, especially for pigmented lesions. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Comparison of basal cell carcinoma subtypes observed in preoperative biopsy and Mohs micrographic surgery,
Conclusions: The agreement between the histopathological subtypes of basal cell carcinoma as seen in preoperative biopsy and Mohs surgery was low. However, preoperative biopsy presented good accuracy (83%) in detecting aggressive histopathological subtypes. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Atypical manifestations of recent syphilis: study of 19 cases,
Conclusions: In view of the findings of the present investigation, it is important to emphasize that all patients who present with cord-like lesions on the penis must undergo a rapid test for syphilis, VDRL, serologies for HIV viral hepatitis B and C and, whenever possible, histopathological and Doppler exams. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
Outcome of staged excision with pathologic margin control in high-risk basal cell carcinoma of the head region,
Conclusions: High-risk basal cell carcinoma had a high cure rate by staged excision. Patients with more risk factors and those with nasal and recurrent basal cell carcinoma required more staged excisions. Failure of tr eatment is more probable in patients with more risk factors, long-standing lesions, and high-risk pathologic and recurrent basal cell carcinomas. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - November 16, 2020 Category: Dermatology Source Type: research
