Standardization of organoid culture for evaluation of melanogenesis induced by UVB, UVA and visible light,
Conclusions: The standardized model maintained viable melanocytic function for 72 h at room temperature, allowing the investigation of melanogenesis induced by different forms of radiation. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Evaluation of monocyte to high-density lipoprotein ratio, lymphocytes, monocytes, and platelets in psoriasis,
Conclusion: Elevated C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly associated with psoriasis. A positive correlation between C-reactive protein and monocyte-to-high-density-lipoprotein ratio leads to the suggestion that monocyte-to-high-density-lipoprotein ratio might be a reliable parameter in psoriasis during the follow-up. The relationship between the diasease and inflammatory parameters might provide early detection of cardiovascular morbidities in psoriasis patients. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Is macular lymphocytic arteritis limited to the skin? Long-term follow-up of seven patients,
Conclusions: To the best of the authors ’ knowledge, this series presents the longest duration of follow-up reported to date. During this period, none of the patients showed resolution of the lesions despite treatment, nor did any progress to systemic vasculitis. Similarities between clinical and skin biopsy findings support the hypothesis that macular lymphocytic arteritis is a benign, incomplete, and less aggressive form of cutaneous polyarteritis nodosa. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study,
Conclusion: CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for PsV in the Turkish population. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Medical resource consumption of moderate/severe psoriasis in a private health organization of Buenos Aires, Argentina,
Conclusion: This is the first Argentine study that evaluated the costs of moderate/severe psoriasis by taking into consideration the direct medical costs of the disease. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Clinical characteristics and associations of palmoplantar pustulosis: an observational study,
Conclusion: Palmoplantar pustulosis appears to be a distinct entity from psoriasis. Routine thyroid functions test could be analyzed, but patch testing is not required in patients with palmoplantar pustulosis. Also, patients with palmoplantar pustulosis must be evaluated for musculoskeletal symptoms and signs. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Update on parasitic dermatoses,
Abstract These are cutaneous diseases caused by insects, worms, protozoa, or coelenterates which may or may not have a parasitic life. In this review the main ethological agents, clinical aspects, laboratory exams, and treatments of these dermatological diseases will be studied. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - March 30, 2020 Category: Dermatology Source Type: research
Diagnostic and therapeutic guidelines for plaque psoriasis - Brazilian Society of Dermatology
Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of p...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology
CONCLUSION: The experts stated that the therapeutic management of atopic dermatitis is based on skin hydration, topical anti-inflammatory agents, avoidance of triggering factors, and educational programs. Systemic therapy, based on immunosuppressive agents, is only indicated for severe refractory disease and after failure of topical therapy. Early detection and treatment of secondary bacterial and viral infections is mandatory, and hospitalization may be needed to control atopic dermatitis flares. Novel target-oriented drugs such as immunobiologicals are invaluable therapeutic agents for atopic dermatitis. (Source: Anais B...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensus on the diagnostic and therapeutic management of chronic spontaneous urticaria in adults - Brazilian Society of Dermatology
Conclusions: Most of the Brazilian experts in this study partially agreed with the diagnostic and therapeutic recommendations of the International and US guidelines. They agreed with the use of sgAH at licensed doses. Increase in the dose to fourfold of sgAH may be suggested with restrictions, due to its non-licensed dose. Sedating anti-histamines, as suggested by the US guideline, are indicated by some of the Brazilian experts, due to its availability. Adaptations are mandatory in the treatment of CSU, due to scarce or lack of other therapeutic resources in the public health system in Brazil, such as omalizumab or cyclosp...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensus on the treatment of autoimmune bullous dermatoses: dermatitis herpetiformis and linear IgA bullous dermatosis - Brazilian Society of Dermatology
Abstract: Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors ’ experience, aiming at the treatment orientation of these diseases ...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita - Brazilian Society of Dermatology
Abstract: Bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases whose antigenic target is located at the basement membrane zone. Mucous membrane pemphigoid and epidermolysis bullosa acquisita can evolve with cicatricial mucosal involvement, leading to respiratory, ocular and/or digestive sequelae with important morbidity. For each of these dermatoses, a literature review covering all therapeutic options was performed. A flowchart, based on the experience and joint discussion among the authors of this consensus, was constructed to provide treatment...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensus on the treatment of autoimmune bullous dermatoses: pemphigus vulgaris and pemphigus foliaceus - Brazilian Society of Dermatology
Abstract: Pemphigus are intraepidermal autoimmune bullous dermatoses that occur with lesions on the skin and / or mucous membranes. The most frequent types are pemphigus vulgaris and pemphigus foliaceus (classic and endemic). This consensus aims to present a complete and updated review of the treatment of these two more frequent forms of pemphigus, based on the literature and the personal experience of the authors. In moderate and severe cases of pemphigus vulgaris and foliaceus, systemic corticosteroid therapy (prednisone or prednisolone) is the treatment of choice. Adjuvant drugs, usually immunosuppressive drugs (azathio...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensus on the treatment of hidradenitis suppurativa - Brazilian Society of Dermatology
The objective of this work was update on physiopathogenesis, diagnosis and classification of hidradenitis suppurativa and to establish therapeutic recommendations in the Brazilian reality. It was organized as a work group composed of eight dermatologists from several institutions of the country with experience in the treatment of hidradenitis suppurativa and carried out review on the topic. Recommendations were elaborated and voted by modified Delphi system and statistical analysis of the results was performed. The Brazilian consensus on the clinical approach of hidradenitis suppurativa had the support of the Brazilian Soc...
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
Consensuses, guidelines and position papers: the role of the Brazilian Society of Dermatology in the contribution to the best practice of Dermatology
(Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - June 4, 2019 Category: Dermatology Source Type: research
