Cover Image, Volume 171B, Number 8, December 2016
(Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 14, 2016 Category: Genetics & Stem Cells Tags: Cover Image Source Type: research

Genetic factors in neurodegenerative diseases
(Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 21, 2016 Category: Genetics & Stem Cells Authors: Debby W. Tsuang, Thomas D. Bird Tags: Editorial Source Type: research

Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined ‐samples mega‐analysis
Blood‐based microarray studies comparing individuals affected with autism spectrum disorder (ASD) and typically developing individuals help characterize differences in circulating immune cell functions and offer potential biomarker signal. We sought to combine the subject‐level data from previously published studies by mega‐analysis to increase the statistical power. We identified studies that compared ex vivo blood or lymphocytes from ASD‐affected individuals and unrelated comparison subjects using Affymetrix or Illumina array platforms. Raw microarray data and clinical meta‐data were obtained from seven studies...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 30, 2016 Category: Genetics & Stem Cells Authors: Daniel S. Tylee, Jonathan L. Hess, Thomas P. Quinn, Rahul Barve, Hailiang Huang, Yanli Zhang ‐James, Jeffrey Chang, Boryana S. Stamova, Frank R. Sharp, Irva Hertz‐Picciotto, Stephen V. Faraone, Sek Won Kong, Stephen J. Glatt Tags: Rapid Publication Source Type: research

Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study
Alzheimer's disease (AD) is the most common form of dementia and is characterized by impairment in memory, behavioral changes, and gradual loss of autonomy. Since there is a long latent period prior to diagnosis, the aim of this study was to determine whether twenty single nucleotide polymorphisms identified in genome‐wide association analyses of AD are associated with cognitive change in 8,320 white and 2,039 African‐American middle‐aged adults enrolled in the prospective Atherosclerosis Risk in Communities (ARIC) study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), Digit Symbol S...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 30, 2016 Category: Genetics & Stem Cells Authors: Jan Bressler, Thomas H. Mosley, Alan Penman, Rebecca F. Gottesman, Beverly Gwen Windham, David S. Knopman, Lisa M. Wruck, Eric Boerwinkle Tags: Research Article Source Type: research

Psychopathology in 7 ‐year‐old children: Differences in maternal and paternal ratings and the genetic epidemiology
The assessment of children's psychopathology is often based on parental report. Earlier studies have suggested that rater bias can affect the estimates of genetic, shared environmental and unique environmental influences on differences between children. The availability of a large dataset of maternal as well as paternal ratings of psychopathology in 7‐year old children enabled (i) the analysis of informant effects on these assessments, and (ii) to obtain more reliable estimates of the genetic and non‐genetic effects. DSM‐oriented measures of affective, anxiety, somatic, attention‐deficit/hyperactivity, oppositional...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - September 30, 2016 Category: Genetics & Stem Cells Authors: Laura W. Wesseldijk, Iryna O. Fedko, Meike Bartels, Michel G. Nivard, Catharina E. M. van Beijsterveldt, Dorret I. Boomsma, Christel M. Middeldorp Tags: Research Article Source Type: research