American Journal of Medical Genetics Part B: Neuropsychiatric Genetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genetic correlations among psychiatric and immune ‐related phenotypes based on genome‐wide association data
We report significantly correlated loci and highlight those containing genome‐wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations among the immune‐related phenotypes. We discuss our findings in the conte xt of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Authors: Daniel S. Tylee, Jiayin Sun, Jonathan L. Hess, Muhammad A. Tahir, Esha Sharma, Rainer Malik, Bradford B. Worrall, Andrew J. Levine, Jeremy J. Martinson, Sergey Nejentsev, Doug Speed, Annegret Fischer, Eric Mick, Brian R. Walker, Andrew Crawf Tags: RESEARCH ARTICLE Source Type: research

Convergent analysis of genome ‐wide genotyping and transcriptomic data suggests association of zinc finger genes with lithium response in bipolar disorder
In this study, we applied an integrated analytical approach using genome ‐wide expression and genotyping data from BD patients to identify lithium‐responsive genes that may serve as biomarkers of its efficacy. To this purpose, we tested the effect of treatment with lithium chloride 1 mM on the transcriptome of lymphoblasts from 10 lithium responders (LR) and 10 nonre sponders (NR) patients and identified genes significantly influenced by the treatment exclusively in LR. These findings were integrated with gene‐based analysis on genome‐wide genotyping data from an extended sample of 205 BD patients characterized for...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Authors: Claudia Pisanu, Donatella Congiu, Marta Costa, Caterina Chillotti, Raffaella Ardau, Giovanni Severino, Andrea Angius, Urs Heilbronner, Liping Hou, Francis J. McMahon, Thomas G. Schulze, Maria Del Zompo, Alessio Squassina Tags: RESEARCH ARTICLE Source Type: research

Ethnic variation of IL ‐4 intron 3 VNTR gene polymorphism; its association with type 2 diabetes mellitus and its complication (neuropathy) in Egyptian subjects
This study aimed to investigate the association ofIL ‐4 VNTR gene polymorphism with T2DM complicated with neuropathy in Egyptian subjects. This is a case control study including 102 T2DM Egyptian patients, plus 188 unrelated healthy individuals as controls. They were evaluated for variable number tandem repeat (VNTR); 70 base pair repeats located in the intron 3; ofIL ‐4 gene using the PCR technique. Homozygote frequency of the three ‐repeat allele (A1/A1) genotype ofIL ‐4 VNTR was nearly equal among diabetic cases and controls (60.8% vs. 62.2%, respectively). Heterozygous frequency of (A1/A2) genotype was higher a...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Authors: R. Ali, A. El ‐Said, H. El‐Baz, A. Settin Tags: RESEARCH ARTICLE Source Type: research

“Like parent, like child”: Attention deficit hyperactivity disorder‐like characteristics in parents of ADHD cases
The objective of this study was to characterize an attention deficit hyperactivity disorder (ADHD) endophenotype in non ‐affected parents of adolescents with a history of ADHD, based on the relationship between performance on a sustained attention test (continuous performance task, or CPT) and polymorphisms of theDRD4 gene. In a sample of 25 non ‐affected parents of adolescents with ADHD history obtained from a longitudinal study of a nonclinical population, and 25 non‐affected parents of adolescents with no ADHD history, four groups were evaluated with respect to the presence or absence of the long allele polymorphi...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Authors: Salvador Trejo, Esmeralda Matute, Mar ía de Lourdes Ramírez‐Dueñas, Adriana P. Mendizabal‐Ruiz, Yaira Chamorro, José A. Morales Tags: RESEARCH ARTICLE Source Type: research

Biobehavioral composite of social aspects of anxiety in young adults with fragile X syndrome contrasted to autism spectrum disorder
Social anxiety is a common disorder that has negative impacts across multiple domains of function. Several clinical groups are at elevated risk for social anxiety, including those with fragile X syndrome and those with autism spectrum disorder. Measuring social anxiety in these clinical subgroups is fraught with challenge, however, given the complexity of social anxiety and measurement limitations that are particularly acute in persons with neurodevelopmental disorders. The over ‐arching aim of this study was to contribute to our understanding of the nature of social anxiety in fragile X syndrome and its association with...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Authors: Jane E. Roberts, Jordan E. Ezell, Amanda J. Fairchild, Jessica Klusek, Angela J. Thurman, Andrea McDuffie, Leonard Abbeduto Tags: RESEARCH ARTICLE Source Type: research

Cover Image, Volume 177B, Number 7, October 2018
(Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Tags: Cover Image Source Type: research

Issue Information ‐ TOC
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 177, Issue 7, Page 597-598, October 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 10, 2018 Category: Genetics & Stem Cells Tags: Issue Information ‐ TOC Source Type: research

DRD4 methylation as a potential biomarker for physical aggression: An epigenome ‐wide, cross‐tissue investigation
AbstractEpigenetic processes that regulate gene expression, such as DNA methylation (DNAm), have been linked to individual differences in physical aggression. Yet, it is currently unclear whether: (a) DNAm patterns in humans associate with physical aggression independently of other co ‐occurring psychiatric and behavioral symptoms; (b) whether these patterns are observable across multiple tissues; and (c) whether they may function as a causal versus noncausal biomarker of physical aggression. Here, we used a multisample, cross‐tissue design to address these questions. First, we examined genome‐wide DNAm patterns (buc...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 9, 2018 Category: Genetics & Stem Cells Authors: Charlotte A. M. Cecil, Esther Walton, Jean ‐Baptiste Pingault, Nadine Provençal, Irene Pappa, Frank Vitaro, Sylvana Côté, Moshe Szyf, Richard E. Tremblay, Henning Tiemeier, Essi Viding, Eamon J. McCrory Tags: RESEARCH ARTICLE Source Type: research

Biomarkers for major depressive and bipolar disorders using metabolomics: A systematic review
AbstractMajor depressive disorder (MDD) and bipolar disorder (BD) lack robust biomarkers useful for screening purposes in a clinical setting. A systematic review of the literature was conducted on metabolomic studies of patients with MDD or BD through the use of analytical platforms such as in vivo brain imaging, mass spectrometry, and nuclear magnetic resonance. Our search identified a total of 7,590 articles, of which 266 articles remained for full ‐text revision. Overall, 249 metabolites were found to be dysregulated with 122 of these metabolites being reported in two or more of the studies included. A list of biomark...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 8, 2018 Category: Genetics & Stem Cells Authors: Kellie MacDonald, Ankur Krishnan, Emily Cervenka, Grace Hu, Elena Guadagno, Yannis Trakadis Tags: RESEARCH REVIEW Source Type: research

Introduction to special section on Leveraging Electronic Health Records for psychiatric genetic research
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 1, 2018 Category: Genetics & Stem Cells Authors: Anjen é M. Addington Source Type: research

Gene ‐level associations in suicide attempter families show overrepresentation of synaptic genes and genes differentially expressed in brain development
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 1, 2018 Category: Genetics & Stem Cells Authors: Marcus Sokolowski, Jerzy Wasserman, Danuta Wasserman Source Type: research

Gene ‐level associations in suicide attempter families show overrepresentation of synaptic genes and genes differentially expressed in brain development
This study complemented previous GWAS on SB outcomes, implicating both previous candidate (e.g.,GRIN2B andGNAS) and novel genes in SA outcomes, as well as synaptic functions and brain development. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Authors: Marcus Sokolowski, Jerzy Wasserman, Danuta Wasserman Tags: ORIGINAL ARTICLE Source Type: research

Exome sequencing of sporadic childhood ‐onset schizophrenia suggests the contribution of X‐linked genes in males
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - October 31, 2018 Category: Genetics & Stem Cells Authors: Amirthagowri Ambalavanan, Boris Chaumette, Sirui Zhou, Pingxing Xie, Qin He, Dan Spiegelman, Alexandre Dionne ‐Laporte, Cynthia V. Bourassa, Martine Therrien, Daniel Rochefort, Lan Xiong, Patrick A. Dion, Ridha Joober, Judith L. Rapoport, Source Type: research