American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,Volume 177, Issue 3, Page 319-328, April 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 15, 2017 Category: Genetics & Stem Cells Source Type: research
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,Volume 177, Issue 3, Page 308-318, April 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 15, 2017 Category: Genetics & Stem Cells Source Type: research
Familial transmission of externalizing syndromes in extended Swedish families
We examined 844,109 probands born in Sweden 1980–1990, their parents, aunts/uncles, and grandparents for registration in population‐based registers for CB, AUD, and DA. Mean tetrachoric relative‐proband correlations (95% CIs) were highest for DA (+0.24, 0.24–0.25), followed by CB (+0.23,0.22–0.23) and AUD (+0.17, 0.16–0.17). AUD and CB were relatively stably transmitted across generations, while DA resemblance among relatives was stronger in the younger generations. For all three syndromes, male‐male transmission was modestly stronger than female–female. Cross‐sex transmission was significantly weaker tha...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 15, 2017 Category: Genetics & Stem Cells Authors: Kenneth S. Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist Tags: RESEARCH ARTICLE Source Type: research
Emotional and behavioral problems in children and adolescents with neurofibromatosis type 1
To assess emotional and behavioral problems in children and adolescents with neurofibromatosis type 1,parents of 183 individuals aged 10.8 ± 3.1 years (range 6‐17) completed the Child Behavior Checklist (CBCL). Also, 173 teachers completed the Teacher's Report Form (TRF), and 88 adolescents (children from 11 to 17 years) completed the Youth Self‐Report (YSR). According to parental ratings, 32% scored in the clinical range (above the 90th percentile). This percentage was much lower when rated by teachers or adolescents themselves. Scores from all informants on scales for Somatic complaints, Social problems, and Att...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 15, 2017 Category: Genetics & Stem Cells Authors: Andr é B. Rietman, Thijs van der Vaart, Ellen Plasschaert, Bethany A. Nicholson, Rianne Oostenbrink, Lianne C. Krab, Mie‐Jef Descheemaeker, Marie‐Claire Y.de Wit, Henriëtte A. Moll, Eric Legius, Pieter F.A.de Nijs Tags: RESEARCH ARTICLE Source Type: research
Issue Information ‐ TOC
(Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 12, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION ‐ TOC Source Type: research
Cover Image, Volume 177B, Number 1, January 2018
The cover image, by Sali M. K. Farhan et al., is based on the Research Article OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia, DOI: 10.1002/ajmg.b.32606. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - December 12, 2017 Category: Genetics & Stem Cells Authors: Sali M. K. Farhan, Tania F. Gendron, Leonard Petrucelli, Robert A. Hegele, Michael J. Strong Tags: COVER IMAGE Source Type: research
Polygenic risk scores distinguish patients from non ‐affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi‐affected kindreds
We examined 1227 subjects: from 17 SZ and BD kindreds, we studied 153 patients (57 SZ, 13 schizoaffective, and 83 BD) and 180 NAARs, and 894 unrelated controls from the Eastern Quebec population. PRS were derived from published case‐control association studies of SZ and BD. We also constructed a combined SZ and BD PRS by using SNPs from both SZ and BD PRS. SZ patients had higher SZ PRS than controls (p = 0.0039, R2 = 0.027) and BD patients had higher BD PRS than controls (p = 0.013, R2 = 0.027). Differences between affected subjects and NAARs and controls were significant with both SZ and BD PRS. Moreover...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 28, 2017 Category: Genetics & Stem Cells Authors: S ébastien Boies, Chantal Mérette, Thomas Paccalet, Michel Maziade, Alexandre Bureau Tags: RESEARCH ARTICLE Source Type: research
Polygenic risk scores distinguish patients from non ‐affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi‐affected kindreds
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,Volume 177, Issue 3, Page 329-336, April 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 28, 2017 Category: Genetics & Stem Cells Authors: S ébastien Boies
,
Chantal Mérette
,
Thomas Paccalet
,
Michel Maziade
,
Alexandre Bureau Source Type: research
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,Volume 177, Issue 3, Page 329-336, April 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 28, 2017 Category: Genetics & Stem Cells Source Type: research
Mutation spectra and founder effect of TMC1 in patients with non ‐syndromic deafness in Xiamen area, China
To analyze the spectrum and founder effect of TMC1 mutations in patients with non‐syndromic deafness in the Xiamen area. Sporadic pedigrees were detected by targeted next‐generation sequencing, and 110 unrelated patients from Xiamen Special Education School were analyzed through Sanger sequencing for the TMC1 gene. In total, 53 SNPs were designed to analyze the haplotypes of the TMC1 c.2050G>C mutation. The probands of three families were found to be homozygous for TMC1 c.2050G>C, and their parents were all heterozygous for the TMC1 c.2050G>C mutation. In 110 unrelated patients from Xiamen Special Education Sc...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 27, 2017 Category: Genetics & Stem Cells Authors: Yi Jiang, Song Gao, Lihua Wu, Xiaohua Jin, Tao Deng, Ligang Wang, Shasha Huang, Xue Gao, Juan Chen, Dongyi Han, Huafang Gao, Pu Dai Tags: RESEARCH ARTICLE Source Type: research
Mutation spectra and founder effect of TMC1 in patients with non ‐syndromic deafness in Xiamen area, China
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,Volume 177, Issue 3, Page 301-307, April 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 27, 2017 Category: Genetics & Stem Cells Authors: Yi Jiang
,
Song Gao
,
Lihua Wu
,
Xiaohua Jin
,
Tao Deng
,
Ligang Wang
,
Shasha Huang
,
Xue Gao
,
Juan Chen
,
Dongyi Han
,
Huafang Gao
,
Pu Dai Source Type: research
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,Volume 177, Issue 3, Page 301-307, April 2018. (Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics)
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 27, 2017 Category: Genetics & Stem Cells Source Type: research
SLC6A3 polymorphism and response to methylphenidate in children with ADHD: A systematic review and meta ‐analysis
Methylphenidate (MPH) is the most commonly used treatment for attention‐deficit hyperactivity disorder (ADHD) in children. However, the response to MPH is not similar in all patients. This meta‐analysis investigated the potential role of SLC6A3 polymorphisms in response to MPH in children with ADHD. Clinical trials or naturalistic studies were selected from electronic databases. A meta‐analysis was conducted using a random‐effects model. Cohen's d effect size and 95% confidence intervals (CIs) were determined. Sensitivity analysis and meta‐regression were performed. Q‐statistic and Egger's tests were conducted ...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - November 24, 2017 Category: Genetics & Stem Cells Authors: Robabeh Soleimani, Zivar Salehi, Soheil Soltanipour, Tolou Hasandokht, Mir Mohammad Jalali Tags: REVIEW ARTICLE Source Type: research
