Rifampin
is a semisynthetic, broad-spectrum antibiotic derivative of rifamycin B, which was derived from Streptomyces mediterranei. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Rifabutin
is a semisynthetic ansamycin antibiotic derived from rifamycin S. It is structurally related to rifampin and is similar to rifampin in many of its properties, including its spectrum of activity against gram-negative and -positive organisms. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Ribavirin
is a synthetic nucleoside agent that has a broad spectrum of antiviral activity against both DNA and RNA viruses. [#] Ribavirin is structurally related to pyrazofurin (pyrazomycin), guanosine, and xanthosine. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Poly-L-lactic acid
(PLLA) is a biocompatible, biodegradable, and immunologically inert synthetic polymer from the alpha-hydroxy-acid family. Microparticles of PLLA are the active ingredient in Sculptra, the injectable implant used for treatment of facial atrophy. [#] [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Pentamidine
isethionate is an aromatic, diamidine-derivative antiprotozoal agent. It is structurally and pharmacologically similar to stilbamidine. The presence of a benzenecarboximidamide (aromatic amidine, benzamidine) group is associated with pentamidine's trypanosomicidal activity, and the presence of both benzenecarboximidamide groups is necessary for this activity. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Peginterferon alfa-2
Interferons alfa-2a and -2b are biosynthetic forms of interferon alfa and consist of 165 amino acids. Interferons alfa-2a and -2b differ at amino acid position 23; alfa-2a has a lysine in that position, whereas -2b has an arginine at that position. Compared to other interferon alfa subtypes, interferons alfa-2a and -2b both have a deletion at position 44 in the amino acid sequence. [#] Peginterferon alfa-2a is a covalent conjugate of recombinant alfa-2a interferon with a single branched bis-monomethoxy polyethlyene glycol (PEG) chain. The PEG moiety is linked at a single site via a stable amide bond to lysine. Peginterfero...
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Paclitaxel
is a natural or semisynthetic antineoplastic diterpene extracted from the bark of the Western (Pacific) yew (Taxus brevifolia) or from needles and twigs of a more prevalent yew (Taxus baccata). [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Megestrol acetate
is a synthetic derivative of the naturally occurring steroid hormone, progesterone. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Itraconazole
, a synthetic triazole derivative, is an azole antifungal agent. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Isoniazid
is a synthetic isonicotinic acid-derivative antitubercular agent. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Interferon alfa-2
The interferon alfa family comprises a number of highly homologous, species-specific proteins and glycoproteins. [#] Naturally occurring interferon alfa is a protein with antiviral, antiproliferative, and immunomodulating activity. Interferons alfa-2a and -2b are of recombinant DNA origin and exist as single interferon subtype preparations. They are commercially available as peginterferons alfa-2a and -2b, which contain the drugs covalently bound to polyethylene glycol (PEG) monomethoxy ether. [#] Interferon alfa-2a and -2b are synthetic interferons manufactured by recombinant DNA technology using a genetically engineered...
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Immune globulin
Intravenous immune globulin (IVIG) preparations consist of concentrated immunoglobulins (Ig), principally immunoglobulin G (IgG), with a subclass distribution that largely reflects that of IgG in normal human serum. Pooled serum is collected from large numbers of donors, ranging from 1,000 to more than 50,000, depending on the manufacturer. All U.S. IVIG manufacturers use Cohn-Oncley ethanol fractionation (fraction II) as an initial step in the preparation of immunoglobulin. Subsequent steps differ among preparations and include ion exchange chromatography, ultrafiltration, enzymatic digestion, manipulation of the pH and s...
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Ganciclovir
is a synthetic, acyclic purine nucleoside analogue of guanine. It is structurally and pharmacologically similar to acyclovir and is active against herpesviruses. [#] Compared to acyclovir, ganciclovir differs structurally such that it has substantially increased antiviral activity against cytomegalovirus (CMV) and less selectivity for viral DNA. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Fluconazole
, a synthetic triazole derivative, is an azole antifungal agent. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
Etoposide
is a semisynthetic podophyllotoxin-derived antineoplastic agent. [#] (Source: Aids Info Drugs)
Source: Aids Info Drugs - February 16, 2016 Category: Drugs & Pharmacology Source Type: research
