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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 31, 2018 Category: Cytology Source Type: research
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
This study provides the first evidence that, in older adults, metformin has metabolic and nonmetabolic effects linked to aging. These data can inform the development of biomarkers for the effects of metformin, and potentially other drugs, on key aging pathways. (Source: Aging Cell)
Source: Aging Cell - January 31, 2018 Category: Cytology Authors: Ameya S Kulkarni, Erika F Brutsaert, Valentin Anghel, Kehao Zhang, Noah Bloomgarden, Michael Pollak, Jessica C Mar, Meredith Hawkins, Jill P Crandall, Nir Barzilai Tags: Short Take Source Type: research
Long ‐lasting pathological consequences of overexpression‐induced α‐synuclein spreading in the rat brain
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 30, 2018 Category: Cytology Source Type: research
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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 30, 2018 Category: Cytology Source Type: research
Long ‐lasting pathological consequences of overexpression‐induced α‐synuclein spreading in the rat brain
In this study, the effects of overexpression‐induced α‐synuclein transfer were assessed over a 1‐year period after injection of viral vectors carrying human α‐synuclein DNA into the rat vagus nerve. This treatment causes targeted overexpression within neurons in the dorsal medulla oblongata and subsequent diffusion of the exogenous protein toward more rostral brain regions. Protein advancement and accumulation in pontine, midbrain, and forebrain areas were contingent upon continuous overexpression, because death of transduced medullary neurons resulted in cessation of spreading. Lack of sustained spreading did no...
Source: Aging Cell - January 30, 2018 Category: Cytology Authors: Raffaella Rusconi, Ayse Ulusoy, Helia Aboutalebi, Donato A. Di Monte Tags: ORIGINAL ARTICLE Source Type: research
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis
Summary
PINK1 (PTEN‐induced putative kinase 1) is a key regulator of mitochondrial homeostasis that is relatively depleted in aging lungs and in lung epithelial cells from patients with idiopathic pulmonary fibrosis (IPF), a disease linked with aging. Impaired PINK1 expression and accumulation of damaged mitochondria in lung epithelial cells from fibrotic lungs were associated with the presence of ER stress. Here, we show that ATF3 (activating transcription factor 3), a member of the integrated stress response (ISR), negatively regulates transcription of the PINK1 gene. An ATF3 binding site within the human PINK1 promote...
Source: Aging Cell - January 24, 2018 Category: Cytology Authors: Marta Bueno, Judith Brands, Lauren Voltz, Kaitlin Fiedler, Brenton Mays, Claudette St. Croix, John Sembrat, Rama K. Mallampalli, Mauricio Rojas, Ana L. Mora Tags: ORIGINAL ARTICLE Source Type: research
ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 24, 2018 Category: Cytology Source Type: research
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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 24, 2018 Category: Cytology Source Type: research
Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging
Summary
Mitochondrial function in human skeletal muscle declines with age. Most evidence for this decline comes from studies that assessed mitochondrial function indirectly, and the impact of such deterioration with respect to physical function has not been clearly delineated. We hypothesized that mitochondrial respiration in permeabilized human muscle fibers declines with age and correlates with phosphocreatine postexercise recovery rate (kPCr), muscle performance, and aerobic fitness. Mitochondrial respiration was assessed by high‐resolution respirometry in saponin‐permeabilized fibers from vastus lateralis muscle bi...
Source: Aging Cell - January 22, 2018 Category: Cytology Authors: Marta Gonzalez ‐Freire, Paul Scalzo, Jarod D'Agostino, Zenobia A. Moore, Alberto Diaz‐Ruiz, Elisa Fabbri, Ariel Zane, Brian Chen, Kevin G. Becker, Elin Lehrmann, Linda Zukley, Chee W. Chia, Toshiko Tanaka, Paul M. Coen, Michel Bernier, Rafael Cabo, Lu Tags: ORIGINAL ARTICLE Source Type: research
Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 21, 2018 Category: Cytology Source Type: research
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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 21, 2018 Category: Cytology Source Type: research
T ‐cell Immunoglobulin and ITIM Domain Contributes to CD8+ T‐cell Immunosenescence
In this study, we showed that T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif (ITIM) domain (TIGIT), a novel co‐inhibitory receptor, was upregulated in CD8+ T cells of elderly adults. Aged TIGIT+ CD8+ T cells expressed high levels of other inhibitory receptors including PD‐1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown. CD226 d...
Source: Aging Cell - January 19, 2018 Category: Cytology Authors: Yangzi Song, Beibei Wang, Rui Song, Yu Hao, Di Wang, Yuxin Li, Yu Jiang, Ling Xu, Yaluan Ma, Hong Zheng, Yaxian Kong, Hui Zeng Tags: ORIGINAL ARTICLE Source Type: research
T ‐cell Immunoglobulin and ITIM Domain Contributes to CD8+ T‐cell Immunosenescence
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 19, 2018 Category: Cytology Source Type: research
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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - January 19, 2018 Category: Cytology Source Type: research
