Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age ‐associated neurogenic decline
In this study, we compare the transcriptional, histone methylation and DNA methylation signatures of NSPCs derived from the subventricular zone (SVZ) of young adult (3 months old) and aged (18 months old) mice. Surprisingly, the transcriptional and epigenomic profiles of SVZ‐derived NSPCs are largely unchanged in aged cells. Despite the global similarities, we detect robust age‐dependent changes at several hundred genes and regulatory elements, thereby identifying putative regulators of neurogenic decline. Within this list, the homeobox gene Dbx2 is upregulated in vitro and in vivo, and its promoter region has alte...
Source: Aging Cell - March 5, 2018 Category: Cytology Authors: Giuseppe Lupo, Paola S. Nisi, Pilar Esteve, Yu ‐Lee Paul, Clara Lopes Novo, Ben Sidders, Muhammad A. Khan, Stefano Biagioni, Hai‐Kun Liu, Paola Bovolenta, Emanuele Cacci, Peter J. Rugg‐Gunn Tags: ORIGINAL ARTICLE Source Type: research
Sex ‐specific regulation of aging in Caenorhabditis elegans
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 1, 2018 Category: Cytology Source Type: research
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Aging Cell, Ahead of Print. (Source: Aging Cell)
Source: Aging Cell - March 1, 2018 Category: Cytology Source Type: research
Resilience to aging in the regeneration ‐capable flatworm Macrostomum lignano
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - February 28, 2018 Category: Cytology Source Type: research
Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti ‐inflammatory and angiogenic environment in aging mice
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - February 28, 2018 Category: Cytology Source Type: research
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Aging Cell, Ahead of Print. (Source: Aging Cell)
Source: Aging Cell - February 28, 2018 Category: Cytology Source Type: research
Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - February 27, 2018 Category: Cytology Source Type: research
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Aging Cell, Ahead of Print. (Source: Aging Cell)
Source: Aging Cell - February 27, 2018 Category: Cytology Source Type: research
The companion dog as a model for human aging and mortality
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - February 19, 2018 Category: Cytology Source Type: research
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Aging Cell, Ahead of Print. (Source: Aging Cell)
Source: Aging Cell - February 19, 2018 Category: Cytology Source Type: research
Aging impacts CD103+CD8+ T cell presence and induction by dendritic cells in the genital tract
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - February 18, 2018 Category: Cytology Source Type: research
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Aging Cell, Ahead of Print. (Source: Aging Cell)
Source: Aging Cell - February 18, 2018 Category: Cytology Source Type: research
