MicroRNA-based therapy in pain medicine: Current progress and future prospects.
Abstract
MicroRNAs (miRNAs) are small noncoding RNA molecules of 18-25 nucleotides in length that regulate gene expression involved in fundamental cell processes. The induction and chronification of pain is associated with many expressional changes in pain-related proteins. miRNA has the potential to regulate gene and protein expression associated with the induction and chronification of pain. Thus, miRNAs might have promise in therapy and as a diagnostic and prognostic biomarker in pain medicine. The application of miRNA has been an emerging field in pain research in recent years. Many studies focusing on...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2013 Category: Anesthesiology Authors: Tan PH, Pao YY, Cheng JK, Hung KC, Liu CC Tags: Acta Anaesthesiol Taiwan Source Type: research
Pneumoperitoneum complicated pneumomediastinum causing cardiovascular deterioration in a low-body-weight premature infant during laparoscopic Nissen fundoplication.
Abstract
Due to smaller incisions, fewer wound injuries, and a shorter time of recovery, laparoscopic procedures are becoming increasingly popular in pediatric surgery, but the safety of their application in low-body-weight or premature infants should be a major concern. Here we present a case report of a 3-month-old premature infant, who developed a sudden change of hemodynamic instability while undergoing a laparoscopic Nissen's fundoplication for gastroesophageal reflex disease. This was thought to result from an accidental passage of massive insufflation of carbon dioxide gas across the diaphragm, lead...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2013 Category: Anesthesiology Authors: Lin MC, Lee CL, Chen CY, Rau RH Tags: Acta Anaesthesiol Taiwan Source Type: research
Difficult fiber-optic intubation in a patient with giant neck masses: The role of McCoy laryngoscope in elevating compressed laryngeal aperture.
Abstract
Airway management in patients with giant neck masses is usually a challenge to anesthesiologists. A giant neck mass could compress the airway and thus impede endotracheal intubation. We encountered a situation where the giant neck masses of a patient pushed the epiglottis posteriorly toward the posterior pharyngeal wall and compressed the laryngeal aperture narrowing after anesthetic induction, causing direct laryngoscopic intubation and sequential fiber-optic intubation failed. The neck masses twisted the aryepiglottic fold tortuously and clogged the laryngeal aperture tightly, making a flexible ...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2013 Category: Anesthesiology Authors: Yeh L, Chen HS, Tan PH, Liu PH, Hsieh SW, Hung KC Tags: Acta Anaesthesiol Taiwan Source Type: research
Compartment syndrome and rhabdomyolysis as a positioning complication following retrosigmoid craniotomy.
Abstract
The goal of surgical positioning is to provide optimal surgical access and visualization while maintaining the patient's safety, with the least physiological compromise. Here, we report a 30-year-old man with an unremarkable past medical history who developed superior vena cava syndrome after a 15-hour retrosigmoid craniotomy for removal of a right cerebellopontine (CP) angle tumor. Compartment syndrome from the head to neck and rhabdomyolysis were recognized, with extensive swelling of his head and neck, markedly swollen soft tissues and necrosis of multiple muscles revealed by computed tomograph...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2013 Category: Anesthesiology Authors: Lin SP, Sung CS, Chan KH Tags: Acta Anaesthesiol Taiwan Source Type: research
Double lumen tube with hook (Carlens) and tracheostomy.
PMID: 24529677 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2013 Category: Anesthesiology Authors: Calenda E, Peillon C, Baste JM Tags: Acta Anaesthesiol Taiwan Source Type: research
Pleiotropic vascular protective effects of statins and anesthetic management.
PMID: 24148736 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Lu CC, Ho ST Tags: Acta Anaesthesiol Taiwan Source Type: research
Feasibility of combined paravertebral block and subcostal transversus abdominis plane block in postoperative pain control after minimally invasive esophagectomy.
CONCLUSION: PVB in combination with subcostal TAP block could reduce morphine consumption and pain severity in the early postoperative period but did not offer other clinical benefits in MIE.
PMID: 24148737 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Li NL, Liu CC, Cheng SH, Hung CF, Lai WJ, Chao IF, Peng WL, Chen CM Tags: Acta Anaesthesiol Taiwan Source Type: research
Factors affecting the duration of mechanical ventilation in patients after intestinal transplantation: Preliminary results.
CONCLUSION: Postoperative blood loss and postoperative respiratory complications might be the factors responsible for delayed extubation in ITx patients. Because the study had few examinees, further studies with a larger population are needed to verify these issues.
PMID: 24148738 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Ting MJ, Chen Y, Chang SC Tags: Acta Anaesthesiol Taiwan Source Type: research
Timing of epidural analgesia intervention for labor pain in nulliparous women in Taiwan: A retrospective study.
CONCLUSION: Our results revealed that the timing of epidural intervention affects neither the cesarean delivery rate nor the instrumental delivery rate on nulliparae in Taiwan with the cervical dilatation width ranging from 1 cm to 4 cm. The fear of increasing cesarean section rate after early epidural analgesia is unfounded. Women in labor can choose pain relief at any time.
PMID: 24148739 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Chen YL, Chang Y, Yeh YL Tags: Acta Anaesthesiol Taiwan Source Type: research
Thoracotomy for lung lesion does not affect the accuracy of esophageal temperature.
CONCLUSION: The accuracy of esophageal temperature seemed not to be affected during thoracotomy for lung lesion, in comparison with that of tympanic temperature. From clinical viewpoints, the monitoring of esophageal temperature could be more reliable in such surgical situation.
PMID: 24148740 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Liu SK, Chiang YY, Poon KS, Wen YR, Li CY, Liu YF, Chen KB Tags: Acta Anaesthesiol Taiwan Source Type: research
Pleiotropic vascular protective effects of statins in perioperative medicine.
Abstract
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statins) is one of the most commonly prescribed agents for controlling hyperlipidemia. Apart from their lipid-lowering property, statins are well known for their pleiotropic effects, such as improvement of vascular endothelial dysfunction, attenuation of inflammatory responses, stabilization of atherosclerotic plaques, inhibition of vascular smooth muscle proliferation, and modulation of procoagulant activity and platelet function. The vasculoprotective effect of statins is mainly mediated by inhibition of the mevalonate pathway ...
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Fang SY, Roan JN, Luo CY, Tsai YC, Lam CF Tags: Acta Anaesthesiol Taiwan Source Type: research
The immune aspect in neuropathic pain: Role of chemokines.
Abstract
Neuropathic pain is a pathological symptom experienced worldwide by patients suffering with nervous system dysfunction caused by various diseases. Treatment of neuropathic pain is always accompanied by a poor response and undesired adverse effects. Therefore, developing a novel "pain-kill" drug design strategy is critical in this field. Recent evidence demonstrates that neuroinflammation and immune response contributes to the development of neuropathic pain. Nerve damage can initiate inflammatory and immune responses, as evidenced by the upregulation of cytokines and chemokines. In this paper, we ...
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Liou JT, Lee CM, Day YJ Tags: Acta Anaesthesiol Taiwan Source Type: research
Agonal gasps of cardiac arrest victim can aid in confirming tracheal intubation using Umesh's intubation detector.
Abstract
Several patients of cardiac arrest may be found in a state of agonal gasps that are of insufficient tidal volume and are not considered as a sign of life. However, this volume is sufficient enough to cause appreciable inflation and deflation of the reservoir bag of Umesh's intubation detector (UID) as evidenced in all 12 victims of cardiac arrest with gasping efforts in this study. Therefore, we conclude that the agonal gasps during cardiac arrest can reliably be used to confirm tracheal intubation using the UID device.
PMID: 24148743 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Umesh G, Magazine R Tags: Acta Anaesthesiol Taiwan Source Type: research
Brainstem anesthesia presenting as contralateral third nerve palsy following peribulbar anesthesia for cataract surgery.
Abstract
Brainstem anesthesia is a serious complication that has been reported to occur more commonly with retrobulbar anesthesia compared to peribulbar anesthesia. We herein report a case of contralateral third nerve palsy following administration of peribulbar anesthesia for cataract surgery. Two hours after the surgery, the patient recovered completely without any residual neurological deficit. The importance of immediate recognition of clinical signs and symptoms of central spread of the local anesthetic and the mechanical factors of the block that could have contributed to this complication are discus...
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Jaichandran VV, Nair AG, Gandhi RA, Prateeba-Devi N Tags: Acta Anaesthesiol Taiwan Source Type: research
Laryngeal mask airway in interventional bronchoscopy for tracheal lesions.
PMID: 24148745 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - September 1, 2013 Category: Anesthesiology Authors: Fadaizadeh L, Hosseini MS Tags: Acta Anaesthesiol Taiwan Source Type: research
