Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model.
CONCLUSION: These results suggest that propofol may have a protective role for lung cells. This effect is associated with its suppression of oxidative-related enzymes, including iNOS, SOD1, SOD2, and p47phox. In cardiac myocytes and macrophages, propofol also provides an antioxidative effect, probably via its inhibition of iNOS. The overall effect of propofol in the organs may be a combination of its effects on various cells. In addition, a reduction in reactive oxygen species plays a major role in the beneficial effect of propofol on experimental endotoxemia.
PMID: 23385038 [PubMed - in process] (Source: Acta Anae...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Tsai YC, Huang CC, Chu LM, Liu YC Tags: Acta Anaesthesiol Taiwan Source Type: research
Phenothiazine-type antipsychotics may attenuate naloxone-precipitated withdrawal jumping in morphine-dependent mice.
CONCLUSIONS: All six phenothiazine-type antipsychotics could attenuate morphine withdrawal symptoms; in particular, fluphenazine and triflupromazine may potentially be the more appropriate candidates for the treatment of morphine withdrawal symptoms.
PMID: 23385039 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Wu SZ, Chen KT, Chen JY, Sung KC, Wang JJ, Liu KS, Chu CC Tags: Acta Anaesthesiol Taiwan Source Type: research
Mechanisms of ketamine-induced immunosuppression.
Abstract
Ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, is widely used as an intravenous anesthetic agent. It is known to produce increases in blood pressure and stroke volume, which implies its importance in clinical practice. Ketamine has also been shown to possess anti-inflammatory effects. Our previous studies showed that ketamine, at clinically relevant concentrations, can downregulate endotoxin-induced macrophage activation through toll-like receptor-dependent activation of mitogen-activated protein kinases and the transcription factors nuclear factor-kappa B and activator prote...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Liu FL, Chen TL, Chen RM Tags: Acta Anaesthesiol Taiwan Source Type: research
Role of neuroinflammation in morphine tolerance: Effect of tumor necrosis factor-α.
Abstract
Opioids have been used as potent analgesics in clinics for decades; however, their long-term administration leads to tolerance. Two possible mechanisms for drug tolerance are postulated as within-system and between-systems adaptation. The within-system tolerance is involved in the signal transduction of opioid receptors, including downregulation of opioid receptors, uncoupling of G-protein from opioid receptors, and β-arrestin recruitment to opioid receptors, which causes receptor desensitization and internalization/endocytosis. The between-systems tolerance comprehends the glutamatergic receptor...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Shen CH, Tsai RY, Wong CS Tags: Acta Anaesthesiol Taiwan Source Type: research
Hypersensitivity reaction probably induced by sugammadex.
We report here an intellectually compromised 7-year-old boy with cerebral palsy who developed a hypersensitivity reaction several minutes after the administration of sugammadex for subsequent extubation. He developed signs of upper airway stenosis and decreased oxygen saturation, as well as wheals on his neck, chest, and both upper extremities. He was successfully treated with immediate administration of adrenaline and hydrocortisone. A hypersensitivity reaction to sugammadex was suspected on the basis of the patient's clinical course.
PMID: 23385042 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Asahi Y, Omichi S, Adachi S, Kagamiuchi H, Kotani J Tags: Acta Anaesthesiol Taiwan Source Type: research
The role of transesophageal echocardiography in transplantation of an adult-sized kidney to a small child.
We report here a boy weighing 8.4 kg who received transplantation of a kidney donated by his 56.4-kg mother. Since monitoring of the central venous pressure was not accurate enough and Swan-Ganz catheterization was not feasible in this patient for monitoring the fluid status and cardiac function, we used transesophageal echocardiography to guide intravascular volume expansion and to titrate inotropic support during the surgery. It was demonstrated to be a useful tool for optimization of renal perfusion in this scenario. The transplanted graft served its function well.
PMID: 23385043 [PubMed - in process] (Source: ...
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Lin IH, Lin CP, Lin FS, Liu CC, Hung MH, Fan SZ Tags: Acta Anaesthesiol Taiwan Source Type: research
Esophageal bezoar formation due to solidification of enteral feed administered through a malpositioned nasogastric tube: Case report and review of the literature.
We present here one such interesting case of a patient who developed esophageal bezoar due to a malpositioned nasogastric tube for administering a casein-containing feed. In addition, we present a review of the literature.
PMID: 23385044 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Tawfic QA, Bhakta P, Date RR, Sharma PK Tags: Acta Anaesthesiol Taiwan Source Type: research
Intraoperative thyroid storm in a patient with euthyroid multinodular goiter.
PMID: 23385045 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Santhosh MC, Torgal SV, Bhat Pai R, Roopa S, Hegde HV, Rao RP Tags: Acta Anaesthesiol Taiwan Source Type: research
Using midthoracic epidural block for postoperative paralytic ileus.
PMID: 23385046 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Kang HM, Hung CJ Tags: Acta Anaesthesiol Taiwan Source Type: research
Reply to "Using midthoracic epidural block for postoperative paralytic ileus".
PMID: 23385047 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)
Source: Acta Anaesthesiologica Taiwanica - December 1, 2012 Category: Anesthesiology Authors: Lin CS Tags: Acta Anaesthesiol Taiwan Source Type: research
