Analytical and/or Clinical Validation of a Candidate Biomarker for Pain (R61/R33 Clinical Trial Optional)
The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the validation of strong candidate biomarkers and endpoints for pain that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials. Specifically, the focus of this FOA is on advanced analytical and clinical validation of pain biomarkers, biomarker signatures, and/or endpoints using retrospective and/or prospective methods. It is assumed that: 1) a candidate biomarker has already been identified, 2) assay technology has already been developed, and 3) a working hypothesis regar...
Source: NIDDK Funding Opportunities - September 19, 2018 Category: Endocrinology Source Type: funding
Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies to demonstrate the robustness of the target as a pain treatment target. This wi...
Source: NIDDK Funding Opportunities - September 19, 2018 Category: Endocrinology Source Type: funding
Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21 Clinical Trial Not Allowed)
This R21 NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of pain target discovery and validation projects. These studies may involve considerable risk but may lead to a breakthrough in a pain treatment.Teresa L.Z. Jones, M.D. | RFA-NS-18-042 (Source: NIDDK Funding Opportunities)
Source: NIDDK Funding Opportunities - September 19, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Childhood Liver Disease Research Network (ChiLDReN) Scientific and Data Coordinating Center (U24 Clinical Trial Optional)
The purpose of this funding opportunity announcement (FOA) is to continue the support the Childhood Liver Disease Research Network (ChiLDReN) to conduct clinical and translational research on rare pediatric liver diseases. ChiLDReN will be composed of a Scientific and Data Coordination Center (DCC), Clinical Centers (CC) , and the NIDDK/NIH as the sponsor of the Network. ChiLDReN will continue clinical and translational research on pediatric liver diseases that include: Biliary Atresia; Alagille syndrome; alpha-1-antitrypsin deficiency; Progressive Familial Intrahepatic Cholestasis syndromes; Bile acid synthesis defects; M...
Source: NIDDK Funding Opportunities - September 18, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Childhood Liver Disease Research Network (ChiLDReN) Clinical Centers (U01 Clinical Trial Required)
The purpose of this funding opportunity announcement (FOA) is to continue the support the Childhood Liver Disease Research Network (ChiLDReN) to conduct clinical and translational research on rare pediatric liver diseases. ChiLDReN is composed of a Scientific and Data Coordination Center (SDCC) and Clinical Centers (CC). ChiLDReN will continue clinical and translational research on pediatric liver diseases that include: Biliary Atresia; Alagille syndrome; alpha-1-antitrypsin deficiency; Progressive Familial Intrahepatic Cholestasis syndromes; Bile acid synthesis defects; Mitochondrial hepatopathies; Idiopathic Neonatal Hep...
Source: NIDDK Funding Opportunities - September 18, 2018 Category: Endocrinology Source Type: funding
Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required)
The purpose of this Funding Opportunity? Announcement (FOA) is to request research applications that test innovative approaches to improve diabetes and obesity prevention and/or treatment in healthcare settings where individuals receive their medical care?. Research applications should be designed to test practical and sustainable strategies to improve processes of care and health outcomes for individuals with or at risk of diabetes and/or obesity. The research should also focus on approaches with the potential to be broadly disseminated outside the specific setting where it is being tested. The goal of the research is to ...
Source: NIDDK Funding Opportunities - September 17, 2018 Category: Endocrinology Source Type: funding
Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required)
The purpose of this Funding Opportunity Announcement (FOA) is to seek research applications that pilot test approaches to improve diabetes and obesity prevention and/or treatment in healthcare settings where individuals receive their medical care. Research applications should be developed to pilot test practical and sustainable strategies to improve processes of care and health outcomes for individuals with or at risk of diabetes and/or obesity. The research should also focus on approaches with the potential to be broadly disseminated outside the specific setting where it is being tested. The goal is that, if the pilot stu...
Source: NIDDK Funding Opportunities - September 17, 2018 Category: Endocrinology Source Type: funding
Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18 Clinical Trial Required)
The purpose of this Funding Opportunity? Announcement (FOA) is to request research applications that test innovative approaches to improve diabetes and obesity prevention and/or treatment in healthcare settings where individuals receive their medical care?. Research applications should be designed to test practical and sustainable strategies to improve processes of care and health outcomes for individuals with or at risk of diabetes and/or obesity. The research should also focus on approaches with the potential to be broadly disseminated outside the specific setting where it is being tested. The goal of the research is to ...
Source: NIDDK Funding Opportunities - September 17, 2018 Category: Endocrinology Source Type: funding
Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required)
The purpose of this Funding Opportunity Announcement (FOA) is to seek research applications that pilot test approaches to improve diabetes and obesity prevention and/or treatment in healthcare settings where individuals receive their medical care. Research applications should be developed to pilot test practical and sustainable strategies to improve processes of care and health outcomes for individuals with or at risk of diabetes and/or obesity. The research should also focus on approaches with the potential to be broadly disseminated outside the specific setting where it is being tested. The goal is that, if the pilot stu...
Source: NIDDK Funding Opportunities - September 17, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Tissue and Technology Core (TATC) (U24 Clinical Trial Not Allowed)
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network conducts multi-center studies of urologic chronic pelvic pain syndrome (UCPPS), a term used to encompass interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The goal of the MAPP Network is to provide new insights into underlying pathophysiology, natural history, clinical phenotype, and risk factors as a foundation for future clinical intervention efforts and ultimately to improve clinical management. The MAPP Research Network is currently comprised of nine Discovery Sit...
Source: NIDDK Funding Opportunities - September 14, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data Coordinating Core (DCC) (U24 Clinical Trial Not Allowed)
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network conducts multi-center studies of urologic chronic pelvic pain syndrome (UCPPS), a term used to encompass interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The goal of the MAPP Network is to provide new insights into underlying pathophysiology, natural history, clinical phenotype, and risk factors as a foundation for future clinical intervention efforts and ultimately to improve clinical management. The MAPP Research Network is currently comprised of nine Discovery Sit...
Source: NIDDK Funding Opportunities - September 14, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Sites (U01 Clinical Trial Not Allowed)
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network conducts multi-center studies of urologic chronic pelvic pain syndrome (UCPPS), a term used to encompass interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The goal of the MAPP Network is to provide new insights into underlying pathophysiology, natural history, clinical phenotype, and risk factors as a foundation for future clinical intervention efforts and ultimately to improve clinical management. The MAPP Research Network is currently comprised of nine Discovery Sit...
Source: NIDDK Funding Opportunities - September 14, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center (U24 Clinical Trial Not Allowed)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)s Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) conducts multi-site, multi-disciplinary studies of Lower Urinary Tract Dysfunction (LUTD) to better define clinical phenotype, to better describe the impact and diversity of symptoms, and to develop new patient-centric tools for improved measurement of clinical symptoms, all with the goals of informing future clinical studies and improving patient care. The purpose of this Limited Competition Funding Opportunity Announcement (FOA) is to solicit applications from the current LURN ...
Source: NIDDK Funding Opportunities - September 14, 2018 Category: Endocrinology Source Type: funding
Limited Competition for the Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Research Sites (U01 Clinical Trial Not Allowed)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)s Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) conducts multi-site, multi-disciplinary studies of Lower Urinary Tract Dysfunction (LUTD) to better define clinical phenotype, to better describe the impact and diversity of symptoms, and to develop new patient-centric tools for improved measurement of clinical symptoms, all with the goals of informing future clinical studies and improving patient care. The purpose of this Limited Competition Funding Opportunity Announcement (FOA) is to invite applications from current LURN Resea...
Source: NIDDK Funding Opportunities - September 14, 2018 Category: Endocrinology Source Type: funding
Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R01- Clinical Trial Optional)
The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC), in collaboration with the International IBD Genetics Consortium, has identified about 200 susceptibility loci for IBD. The IBDGC has recently been awarded renewed funding to identify causal genes and genetic variants within these loci, and to elucidate the mechanisms through which they contribute to the pathophysiology of IBD. However, the IBDGC's current resources permit them to explore the functions of only a limited set of genes within a limited set of physiological domains. The purpose of this Funding Opportunity Announcement (FOA) is to expand the numbe...
Source: NIDDK Funding Opportunities - September 12, 2018 Category: Endocrinology Source Type: funding
