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Evaluating Dietary Compounds in Pancreatic Cancer Modeling Systems
With the establishment of outstanding rodent models of pancreatic neoplasia and cancer, there are now systems available for evaluating the role diet, dietary supplements, and/or therapeutic compounds (which can be delivered in the diet) play in disease suppression. Several outstanding reports, which demonstrate clear inhibition or regression of pancreatic tumors following dietary manipulations, represent a noticeable advancement in the field by allowing for the contribution of diet and natural and synthetic compounds to be identified. The real goal is to provide support for translational components that will provide true c...
Source: Springer protocols feed by Cancer Research - January 1, 2013 Category: Cancer & Oncology Source Type: news

Development of Orthotopic Pancreatic Tumor Mouse Models
Genetically engineered mouse models of pancreatic cancer that recapitulate human pancreatic tumorigenesis have been established. However, the cost associated with generating and housing these mice can be ­prohibitive. Tumor latency and progression to invasive diseases in these models are also highly variable. Xenograft mouse models of human pancreatic cancer including heterotopic and orthotopic have been widely used in preclinical studies for their comparatively low cost and rapid, predictable tumor growth. Of the two, orthotopic tumor mouse models are preferred because they offer tissue site-specific pathology, allow ...
Source: Springer protocols feed by Cancer Research - January 1, 2013 Category: Cancer & Oncology Source Type: news

The Prevention and Genetics of Pancreatic Cancer: A Programmatic Approach
Pancreatic cancer (PC) is typically a fatal disease due to its rapid growth and the lack of early diagnostic ­techniques. Because approximately 10% of PCs are attributable to a hereditary susceptibility, identifying and studying patients with a family history of PC or known genetic predisposition to PC can improve the prevention, diagnosis, and treatment of PC. A skilled team of study investigators, physicians, genetic counselors, and data managers must work with patients and families to confidentially store and organize data from PC patients and high-risk patients. This data, collected in conjunction with patients&rsq...
Source: Springer protocols feed by Cancer Research - January 1, 2013 Category: Cancer & Oncology Source Type: news