Dicer inactivation stimulates limb regeneration ability in Xenopus laevis
This study investigates the effect of Dicer, an enzyme responsible for microRNA maturation, on limb development and regeneration in Xenopus. Dicer is expressed in the developing Xenopus limbs, and is upregulated after limb amputation during both regeneration‐competent and ‐deficient stages of tadpole development. Inactivation of Dicer in early (NF stage 53) tadpole limb buds leads to shorter tibulare/fibulare formation, but does not affect limb regeneration. However, in late stage, regeneration‐deficient tadpole limbs (NF stage 57), Dicer inactivation restores the regeneration blastema, and stimulates limb regenerati...
Source: Wound Repair and Regeneration - February 17, 2018 Category: Surgery Authors: Mengshi Zhang, Li Yang, Feng Yuan, Ying Chen, Gufa Lin Tags: Original Research ‐Regeneration Science Source Type: research
GM ‐CSF ameliorates microvascular barrier integrity via pericyte‐derived Ang‐1 in wound healing
Abstract
Skin wound healing involves complex coordinated interactions of cells, tissues, and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound‐area, postinjury. Eventually, vessel integrity has to be reestablished for vascular maturation. Numerous studies have found that granulocyte macrophage colony‐stimulating factor (GM‐CSF) accelerates wound healing by inducing recruitment ...
Source: Wound Repair and Regeneration - February 16, 2018 Category: Surgery Authors: Min Yan, Yange Hu, Min Yao, Shisan Bao, Yong Fang Tags: Original Research ‐Basic Science Source Type: research
Noninvasive measurement of reepithelialization and microvascularity of suction ‐blister wounds with benchmarking to histology
Abstract
We explored use of the suction‐blister wound model in the assessment of not only epidermal regeneration but also pain, the microvascular response and bacteriology. The effects of topical zinc sulfate were studied to articulate the methodologies in this double‐blind trial. One epidermal suction blister (10 mm) was induced on each buttock in 30 healthy volunteers (15 females:15 males) and deroofed on day 0. The wounds were randomized to daily treatment with 1.4% zinc sulfate shower gel (n = 20), placebo (n = 20) or control (n = 20). Digital photography coupled with planimetry, transepidermal water lo...
Source: Wound Repair and Regeneration - February 16, 2018 Category: Surgery Authors: Heidi F. Larsen, Malin G. Ahlstr öm, Lise M. R. Gjerdrum, Mette Mogensen, Khaled Ghathian, Henrik Calum, Anne L. Sørensen, Julie L. Forman, Mark Vandeven, Marian N. Holerca, Laurence Du‐Thumm, Lars N. Jorgensen, Magnus S. Ågren Tags: Original Research ‐Clinical Science Source Type: research
GM ‐CSF ameliorates microvascular barrier integrity via pericytes‐derived Ang‐1 in wound healing
Abstract
Skin wound healing involves complex coordinated interactions of cells, tissues, and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound‐area, postinjury. Eventually, vessel integrity has to be reestablished for vascular maturation. Numerous studies have found that granulocyte macrophage colony‐stimulating factor (GM‐CSF) accelerates wound healing by inducing recruitment ...
Source: Wound Repair and Regeneration - February 16, 2018 Category: Surgery Authors: Min Yan, Yange Hu, Min Yao, Shisan Bao, Yong Fang Tags: Original Research ‐Basic Science Source Type: research
Decreased superficial surgical site infections, shortened hospital stay, and improved quality of life due to incisional negative pressure wound therapy after reversal of double loop ileostomy
Abstract
This single‐center prospective, controlled observational study investigates the impact of incisional negative pressure wound therapy on wound healing processes and its potency to prevent superficial surgical site infections (SSSI) after reversal of a double loop ileostomy. Furthermore, this study gains insight in socioeconomic aspects, like duration of hospital stay and, for the first time, patient's quality of life during the incisional negative pressure wound treatment. To address this question, an interventional group of 24 patients treated with incisional negative pressure wound therapy (Prevena incisional w...
Source: Wound Repair and Regeneration - February 12, 2018 Category: Surgery Authors: Daniel Poehnert, Nils Hadeler, Harald Schrem, Alexander Kaltenborn, Juergen Klempnauer, Markus Winny Tags: Original Research ‐Clinical Science Source Type: research
Decreased superficial surgical site infections, shortened hospital stay, and improved quality of live due to incisional negative pressure wound therapy after reversal of double loop ileostomy
Abstract
This single‐center prospective, controlled observational study investigates the impact of incisional negative pressure wound therapy on wound healing processes and its potency to prevent superficial surgical site infections (SSSI) after reversal of a double loop ileostomy. Furthermore, this study gains insight in socioeconomic aspects, like duration of hospital stay and, for the first time, patient's quality of life during the incisional negative pressure wound treatment. To address this question, an interventional group of 24 patients treated with incisional negative pressure wound therapy (Prevena incisional w...
Source: Wound Repair and Regeneration - February 12, 2018 Category: Surgery Authors: Daniel Poehnert, Nils Hadeler, Harald Schrem, Alexander Kaltenborn, Juergen Klempnauer, Markus Winny Tags: Original Research ‐Clinical Science Source Type: research
Probiotics or pro ‐healers: the role of beneficial bacteria in tissue repair
This article reviews the latest findings on probiotics related to their pro‐healing properties on gut epithelium and skin. Proven mechanisms by which probiotic bacteria exert their beneficial effects include direct killing of pathogens, competitive displacement of pathogenic bacteria, reinforcement of epithelial barrier, induction of fibroblasts, and epithelial cells' migration and function. Beneficial immunomodulatory effects of probiotics relate to modulation and activation of intraepithelial lymphocytes, natural killer cells, and macrophages through induced production of cytokines. Systemic effects of beneficial bacte...
Source: Wound Repair and Regeneration - February 9, 2018 Category: Surgery Authors: Jovanka Lukic, Vivien Chen, Ivana Strahinic, Jelena Begovic, Hadar Lev ‐Tov, Stephen C. Davis, Marjana Tomic‐Canic, Irena Pastar Tags: Perspective Article Source Type: research
Constitutive overexpression of periostin delays wound healing in mouse skin
This article is protected by copyright. All rights reserved. (Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - February 8, 2018 Category: Surgery Authors: Satoshi Nunomura, Yasuhiro Nanri, Masahiro Ogawa, Kazuhiko Arima, Yasutaka Mitamura, Tomohito Yoshihara, Hidetoshi Hasuwa, Simon J. Conway, Kenji Izuhara Tags: Original Research ‐Basic Science Source Type: research
Report on the 2nd European Tissue Repair Society summer school, Brussels, September 11 –12th, 2017
(Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - February 6, 2018 Category: Surgery Authors: Gabrielle Dijksteel, Natalia Kuch, Roel C. op 't Veld, Christine Andrews Tags: Letter to the Editor Source Type: research
Risk factors for recurrence of pressure ulcers after defect reconstruction
Conclusions: Supported by the recent literature we identified factors like defect size to be associated with pressure ulcer recurrence, but not with time‐to admission for reconstruction or number of previous debridements. Whether laboratory values like serum albumin levels were the cause, the result or associated with pressure ulcer recurrence warrants further investigation. This article is protected by copyright. All rights reserved. (Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - January 30, 2018 Category: Surgery Authors: Paul Wurzer, Raimund Winter, Sebastian O. Stemmer, Josipa Ivancic, Patricia B. Lebo, Gabriel Hundeshagen, Janos Cambiaso ‐Daniel, Franz Quehenberger, Lars‐Peter Kamolz, David B. Lumenta Tags: Original Research ‐Clinical Science Source Type: research
Neural Crest ‐Derived Cells Migrate from Nerve to Participate in Achilles tendon Remodeling
This article is protected by copyright. All rights reserved. (Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - January 30, 2018 Category: Surgery Authors: Kang Xu, Xin Pan, Xuefeng Qiu, Dong Wang, Nianguo Dong, Li Yang, Song Li Tags: Original Research ‐Regeneration Science Source Type: research
The influence of human acute wound fluid on the antibacterial efficacy of different antiseptic polyurethane foam dressings: an in ‐vitro analysis
This article is protected by copyright. All rights reserved. (Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - January 24, 2018 Category: Surgery Authors: Julian ‐Dario Rembe, Carolin Fromm‐Dornieden, Julia Böhm, Ewa K. Stuermer Tags: Original Research ‐Basic Science Source Type: research
Decreased superficial surgical site infections, shortened hospital stay, and improved quality of life due to incisional negative pressure wound therapy after reversal of double loop ileostomy
Wound Repair and Regeneration,Volume 25, Issue 6, Page 994-1001, November/December 2017. (Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - January 22, 2018 Category: Surgery Source Type: research
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Wound Repair and Regeneration,Volume 25, Issue 6, Page 994-1001, November/December 2017. (Source: Wound Repair and Regeneration)
Source: Wound Repair and Regeneration - January 22, 2018 Category: Surgery Source Type: research
