Altered perineal microbiome is associated with vulvovaginitis and urinary tract infection in preadolescent girls
Conclusions:
Vulvovaginitis may cause UTIs by altering the perineal biome such that there is increased colonization of uropathogens. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - November 18, 2014 Category: Urology & Nephrology Authors: Gorbachinsky, I., Sherertz, R., Russell, G., Krane, L. S., Hodges, S. J. Tags: Original Research Source Type: research
Randomized controlled trial of cyclic and continuous therapy with trospium and solifenacin combination for severe overactive bladder in elderly patients with regard to patient compliance
Conclusions:
Cyclic therapy with two different spectrum antimuscarinics appears to be effective for controlling severe OAB in elderly patients. One-year cyclic therapy with a trospium and solifenacin combination provides a high compliance level (76–84%). However, continuous therapy with standard doses of trospium and solifenacin results in low adherence and high rates of treatment withdrawals (≥ 66%) despite satisfactory clinical and urodynamic results. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - November 18, 2014 Category: Urology & Nephrology Authors: Kosilov, K. V., Loparev, S. A., Ivanovskaya, M. A., Kosilova, L. V. Tags: Original Research Source Type: research
Selection criteria for initiation and renewal of luteinizing hormone-releasing hormone agonist therapy in patients with prostate cancer: a French prospective observational study
Conclusions:
Slow-release formulations of LHRH agonists are useful therapies for physicians treating patients with PCa and there may be a preference for the 6-month formulation. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - November 18, 2014 Category: Urology & Nephrology Authors: Lebret, T., Davin, J.-L., Hennequin, C., Latorzeff, I., Mignard, J.-P., Moreau, J.-L., Rossi, D., Ruffion, A., Zerbib, M., Culine, S. Tags: Original Research Source Type: research
Chronic lymphocytic leukemia of the bladder: an atypical etiology of gross hematuria
We present a 71-year-old woman initially diagnosed with CLL who was plagued by recurrent hematuria and dysuria for over a decade, which lead to multiple negative urologic workups. However, these continued workups eventually lead to her diagnosis of bladder CLL with a subsequent finding of carcinoma in situ that was prompted by a suspicious surveillance cystoscopy performed 4 months after her initial bladder diagnosis. Hence, infiltration of CLL in the urinary bladder merits close follow up, including additional urologic procedures. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - August 19, 2014 Category: Urology & Nephrology Authors: Desai, V., Isharwal, S., Pooli, A., Lele, S., Feloney, M. Tags: Reviews Source Type: research
Experience in the use of collagenase clostridium histolyticum in the management of Peyronie's disease: current data and future prospects
Conclusion:
The combined results of these trials have led to the FDA approval of CCh for the treatment of PD. However, the long-term effects and results need further investigation, with large follow-up series. Considering these results, future perspectives will probably result in the use of a combined or sequential therapy including CCh. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - August 19, 2014 Category: Urology & Nephrology Authors: Egui Rojo, M. A., Moncada Iribarren, I., Carballido Rodriguez, J., Martinez-Salamanca, J. I. Tags: Reviews Source Type: research
Use of intravesical valrubicin in clinical practice for treatment of nonmuscle-invasive bladder cancer, including carcinoma in situ of the bladder
Conclusions:
Data from the present retrospective study are consistent with previous prospective clinical trials that demonstrated valrubicin effectiveness and tolerability for select patients with CIS, before considering cystectomy. Additional prospective studies are warranted to evaluate valrubicin safety and efficacy in the broader patient population with NMIBC. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - August 19, 2014 Category: Urology & Nephrology Authors: Cookson, M. S., Chang, S. S., Lihou, C., Li, T., Harper, S. Q., Lang, Z., Tutrone, R. F. Tags: Original Research Source Type: research
Innovations in the management of Wilms' tumor
Advances in the management of Wilms’ tumor have been dramatic over the past half century, not in small part due to the institution of multimodal therapy and the formation of collaborative study groups. While different opinions exist in the management of Wilms’ tumors depending on where one lives and practices, survival rates have surpassed 90% across the board in Western societies. With more children surviving into adulthood, the concerns about morbidity have reached the forefront and now represent as much a consideration as oncologic outcomes these days. Innovations in treatment are on the horizon in the form ...
Source: Therapeutic Advances in Urology - June 11, 2014 Category: Urology & Nephrology Authors: Gleason, J. M., Lorenzo, A. J., Bowlin, P. R., Koyle, M. A. Tags: Reviews Source Type: research
Best practice in the assessment of bladder function in infants
The purpose of this article is to review normal developmental bladder physiology in infants and bladder dysfunction in conditions such as neurogenic bladder, posterior urethral valves and high grade vesicoureteric reflux. We contrast the classical concept that bladder function in nontoilet-trained children is thought to be ‘reflexive’ or ‘uninhibited’, with the results of more recent research showing that infants most commonly have a stable detrusor. The infant bladder is physiologically distinct from the state seen in older children or adults. The voiding pattern of the infant is characterized by a...
Source: Therapeutic Advances in Urology - June 11, 2014 Category: Urology & Nephrology Authors: Guerra, L., Leonard, M., Castagnetti, M. Tags: Reviews Source Type: research
A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction
Epidemiological data link erectile dysfunction (ED) and benign prostatic hyperplasia (BPH)-associated lower urinary tract symptoms (LUTS), two highly prevalent conditions in aging men, assuming common pathophysiological pathways. Tadalafil 5 mg once daily has been approved for the treatment of men with LUTS with or without comorbid ED. The aim of this review is to provide an overview of current knowledge on the epidemiological and pathophysiological links between ED and LUTS and to focus on tadalafil as a new treatment option in men with BPH-associated LUTS.
A Medline search was completed using the Medical Subject Headings...
Source: Therapeutic Advances in Urology - June 11, 2014 Category: Urology & Nephrology Authors: Hatzimouratidis, K. Tags: Reviews Source Type: research
Diagnosis and therapy for prostate tuberculosis
In its 2012 global report on tuberculosis, the World Health Organization estimated that 3–7% (range 2.1–5.2%) of new cases and 20% (range 13–26%) of previously treated cases had multidrug-resistant tuberculosis (defined as tuberculosis caused by Mycobacterium tuberculosis isolates that are resistant to rifampicin and isoniazid). In many countries in Eastern Europe and central Asia, 9–32% of new patients and more than 50% of previously treated patients have multidrug-resistant tuberculosis.
Ninety-three patients with suspected prostate tuberculosis were enrolled in this study and all underwent prosta...
Source: Therapeutic Advances in Urology - June 11, 2014 Category: Urology & Nephrology Authors: Kulchavenya, E., Brizhatyuk, E., Khomyakov, V. Tags: Original Research Source Type: research
Management of iatrogenic ureteral injury
Iatrogenic injury to the ureter is a potentially devastating complication of modern surgery. The ureters are most often injured in gynecologic, colorectal, and vascular pelvic surgery. There is also potential for considerable ureteral injury during endoscopic procedures for ureteric pathology such as tumor or lithiasis. While maneuvers such as perioperative stenting have been touted as a means to avoid ureteral injury, these techniques have not been adopted universally, and the available literature does not make a case for their routine use. Distal ureteral injuries are best managed with ureteroneocystostomy with or withou...
Source: Therapeutic Advances in Urology - April 29, 2014 Category: Urology & Nephrology Authors: Burks, F. N., Santucci, R. A. Tags: Reviews Source Type: research
Pharmacological treatment of chronic pelvic ischemia
Epidemiological studies have shown that lower urinary tract symptoms, including overactive bladder, commonly occur in both men and women, with an age-related increase in both sexes. Vascular endothelial dysfunction and urological symptoms are common in the metabolic syndrome; they also occur during the human ageing process and are independent risk factors for the development of atherosclerosis and hypertension. Pelvic arterial insufficiency may lead to impaired lower urinary tract perfusion and play an important role in the development of bladder dysfunction such as detrusor overactivity and overactive bladder. It seems re...
Source: Therapeutic Advances in Urology - April 29, 2014 Category: Urology & Nephrology Authors: Andersson, K.-E., Nomiya, M., Sawada, N., Yamaguchi, O. Tags: Reviews Source Type: research
The role of cabazitaxel in the treatment of metastatic castration-resistant prostate cancer
For decades, cytotoxic therapy was considered ineffective for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Earlier therapies such as estramustine and mitoxantrone received regulatory approval based upon improvement in palliative endpoints. In 2004, docetaxel became the first treatment to demonstrate a significant survival benefit in patients with mCRPC based on two randomized phase III studies, TAX327 and SWOG 99-16. Cabazitaxel, a third-generation taxane, was chosen for clinical development based on its decreased affinity for the drug efflux pump, p-glycoprotein, which is a frequent cause of d...
Source: Therapeutic Advances in Urology - April 29, 2014 Category: Urology & Nephrology Authors: Tsao, C.-K., Cutting, E., Martin, J., Oh, W. K. Tags: Reviews Source Type: research
A green and black tea extract benefits urological health in men with lower urinary tract symptoms
Conclusions:
Oral administration of AMH improved LUTS and quality of life in as little as 6 weeks. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - April 29, 2014 Category: Urology & Nephrology Authors: Katz, A., Efros, M., Kaminetsky, J., Herrlinger, K., Chirouzes, D., Ceddia, M. Tags: Original Research Source Type: research
Pelvic floor muscle rehabilitation for patients with lifelong premature ejaculation: a novel therapeutic approach
Conclusions:
The results obtained in our subjects treated with pelvic floor rehabilitation are promising. This therapy represents an important cost reduction compared with the standard treatment (selective serotonin reuptake inhibitors). Based on the present data, we propose pelvic floor muscle rehabilitation as a new, viable therapeutic option for the treatment of premature ejaculation. (Source: Therapeutic Advances in Urology)
Source: Therapeutic Advances in Urology - April 29, 2014 Category: Urology & Nephrology Authors: Pastore, A. L., Palleschi, G., Fuschi, A., Maggioni, C., Rago, R., Zucchi, A., Costantini, E., Carbone, A. Tags: Original Research Source Type: research
