Randomized controlled trial of cyclic and continuous therapy with trospium and solifenacin combination for severe overactive bladder in elderly patients with regard to patient compliance
Conclusions:
Cyclic therapy with two different spectrum antimuscarinics appears to be effective for controlling severe OAB in elderly patients. One-year cyclic therapy with a trospium and solifenacin combination provides a high compliance level (76–84%). However, continuous therapy with standard doses of trospium and solifenacin results in low adherence and high rates of treatment withdrawals (≥ 66%) despite satisfactory clinical and urodynamic results.
Source: Therapeutic Advances in Urology - Category: Urology & Nephrology Authors: Kosilov, K. V., Loparev, S. A., Ivanovskaya, M. A., Kosilova, L. V. Tags: Original Research Source Type: research
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